“…On the other hand, several works have reported the involvement of Cu and Mn in the shikimic acid pathway leading to the biosynthesis of several phenols, such as flavonoids, tannins, and lignin (Santiago et al, 2000;Diaz et al, 2001;Loponen et al, 2001;Lin et al, 2005;Guangqiu et al, 2007). Moreover, it is known that Cu and Mn influence the activity of many cellular enzymes, such as phenylalanine ammonia-lyase (PAL) (Santiago et al, 2000;Kováčik & Klejdus, 2008;Treutter, 2010), peroxidases (Diaz et al, 2001, Lin et al, 2005, Gross, 2008Kováčik et al, 2009), laccases (Lin et al, 2005), and shikimate dehydrogenase (Diaz et al, 2001, Kováčik et al, 2009.…”