Rapid endothelialization of mieroporous vascular prostheses covered with meshed vascular tissue: a preliminary report

Sedlarĭk, K; Wachem, P.B. van; Bartels, H.; Schakenraad, Jm

doi:10.1016/0142-9612(90)90043-p

Cited by 17 publications

(8 citation statements)

References 15 publications

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“…As Patricia d'Amore had already concluded in the 1990s undifferentiated mesenchymal cells may follow these endothelial tubes and be directed by them in their differentiation into SMCs ( 128 ). Although facilitating circumstances such as endothelial-rich peri-graft tissues were shown to potentially augment transmural endothelialisation ( 129 – 131 ) the scaffold itself must allow this process by providing continual, ingrowth-permissible spaces ( 102 ).…”

Section: Limits Of Engineered Tissue Regeneration In Humansmentioning

confidence: 99%

Progressive Reinvention or Destination Lost? Half a Century of Cardiovascular Tissue Engineering

Zilla

Deutsch

Bezuidenhout

et al. 2020

Front. Cardiovasc. Med.

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Section: Limits Of Engineered Tissue Regeneration In Humansmentioning

confidence: 99%

Progressive Reinvention or Destination Lost? Half a Century of Cardiovascular Tissue Engineering

Zilla

Deutsch

Bezuidenhout

et al. 2020

Front. Cardiovasc. Med.

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“…The lactic acid is incorporated in the tricarboxylic acid cycle and will subsequently be excreted as carbon dioxide 1. PLA are frequently utilized in blood‐contacting situations such as vascular prosthesis where temporary reconstruction and/or stabilization of tissue and organs is needed, and intravascular stents that have to maintain blood vessels open after balloon dilatation 2–4. Moreover, these materials are widely used for biomedical application, such as tissue engineering, gene therapy, novel drug delivery systems, implantable devices, and nanotechnology because of their biocompatibility and biodegradability 2, 3.…”

Section: Introductionmentioning

confidence: 99%

Heparin‐conjugated star‐shaped PLA for improved biocompatibility

Joung

Park

et al. 2007

J Biomedical Materials Res

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Star-shaped PLA-heparin (sPLA-Hep) was prepared by coupling heparin to the star-shaped PLA (sPLA) reaction using carbonyldiimidazole (CDI) chemistry. Hydroxyl groups of sPLA were activated by CDI for the reaction with the remained amino-terminal groups of heparin. The surface heparin content of sPLA-Hep was measured to be 1.43 microg/cm(2). sPLA-Hep-coated surface has shown higher hydrophilicity than control surface. The clotting time of sPLA-Hep measured by activated partial thromboplastin time (APTT) was significantly prolonged when compared with sPLA and linear PLA-Hep. sPLA-Hep surface demonstrated lower protein adsorption and platelet adhesion than control sPLA surface. In addition, fibroblast culture on the sPLA-Hep surface showed the enhanced cell spreading area compared with the sPLA surface. Obtained results suggest that the incorporation of heparin to sPLA is effective in curtailing the surface induced-thrombosis and in manipulating the cell interaction. sPLA-Hep could be applied as blood/tissue compatible biodegradable materials for implantable medical devices and tissue engineering.

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“…Several applications of biomaterials in contact with blood might benefit from the use of biodegradable, hemocompatible materials. For example, arterial prosthesis must have a certain porosity to allow the ingrowth of vascularized perigraft tissue and endothelial cells [4]. However, high porosity can result in bleeding through the graft interstices.…”

Section: Introductionmentioning

confidence: 99%

Heparin-modified polylactide as biodegradable hemocompatible biomaterial

Herrmann

Groth

Seifert

et al. 1994

J Mater Sci: Mater Med

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Several medical applications may benefit from biodegradable hemocompatible materials. Therefore a commercial biodegradable polylactide (RESOMER ® R208; Boehringer-lngelheim, Germany) was modified with heparin. The immobilization of heparin was performed by covalent binding with glutaraldehyde as spacer. Reaction conditions were varied to optimize the coupling of heparin. The efficiency of the immobilization and the biological activity of bonded heparin was estimated with a toluidine blue assay and factor Xa assay, respectively. It was shown that an immobilization at ambient temperature and a reaction time of 2 h yielded maximal heparin binding and biological activity. The hemocompatibility of the modified polylactide was tested after blood/material contact with an enzyme immuno assay (EIA) for GMP 140, a marker of platelet activation. The investigated materials were compared with polypropylene and Pellethane ®. After modification it was found that high heparin binding and biological activity were correlated with very small activation of platelets.

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Rapid endothelialization of mieroporous vascular prostheses covered with meshed vascular tissue: a preliminary report

Cited by 17 publications

References 15 publications

Progressive Reinvention or Destination Lost? Half a Century of Cardiovascular Tissue Engineering

Progressive Reinvention or Destination Lost? Half a Century of Cardiovascular Tissue Engineering

Heparin‐conjugated star‐shaped PLA for improved biocompatibility

Heparin-modified polylactide as biodegradable hemocompatible biomaterial

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