Rapid fabrication of carbon quantum dots as multifunctional nanovehicles for dual-modal targeted imaging and chemotherapy

Chiu, Sheng Hui; Gedda, Gangaraju; Girma, Wubshet Mekonnen; Chen, Jem-Kun; Ling, Yong; Ghule, Anil V.; Ou, Keng-Liang; Chang, Jia-Yaw

doi:10.1016/j.actbio.2016.09.027

Cited by 98 publications

(33 citation statements)

References 46 publications

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“…Several researchers have successfully used the CQDs for in vitro bioimaging. 52,[101][102][103][104][105][106][107][108][109][110][111][112][113] In several applications, the QDs are preferred to organic dyes and uorescent proteins due to the enhanced brightness, photostability, imaging sensitivity, and good resistance to metabolic degradation. 114 Semiconductor QDs such as CdSe with their core-shell structure (e.g.…”

Section: Optical Imagingmentioning

confidence: 99%

Carbon quantum dots and their biomedical and therapeutic applications: a review

2019

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Section: Optical Imagingmentioning

confidence: 99%

Carbon quantum dots and their biomedical and therapeutic applications: a review

2019

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“…Another strategy to adjust CQDs' optical properties is doping metallic and paramagnetic ions such as Mn 2+ and Gd 3+ , which not only contributes in turning doped‐CQDs emission but also provides the magnetic properties for the fabrication of fluorescence (FL) and magnetic resonance imaging (MRI) dual‐modal imaging probes (Chiu et al, ; Pan et al, ; Xu, Jia, Yin, He, & Zhang, ; Yao et al, ). Motivated with their potential diagnostic applications, several groups have made attempts to integrate photothermal and photodynamic agents onto paramagnetic‐doped CQDs to fabricate a multifunctional platform for diagnosis and therapy (Chiu et al, ; Du et al, ; Sun, Zhang, Jiang, Wu, & Lin, ).…”

Section: Introductionmentioning

confidence: 99%

Manganese‐doped green tea‐derived carbon quantum dots as a targeted dual imaging and photodynamic therapy platform

et al. 2019

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In this work, manganese‐doped carbon quantum dots (Mn‐CQDs) have been synthesized through a one‐pot hydrothermal method by using waste green tea. The Mn2+ dopants were introduced to impart magnetic resonance capability. Upon optimization of the experimental conditions, magnetofluorescent Mn‐CQDs exhibit an excitation‐dependent blue emission. The abundant functional groups on Mn‐CQDs not only promote water solubility but also allow straightforward functionalization with amine groups. The amine‐terminated Mn‐CQDs were then subsequently conjugated to folic acid (FA) and chlorin e6 (Ce6) to obtain the Mn‐CQDs@FA/Ce6 magnetofluorescent photodynamic therapy (PDT) agent. in vitro studies using three different cells indicated specific targeting of Mn‐CQDs@FA/Ce6 to the overexpressing folate receptor human epithelial carcinoma cell line (HeLa) cancer cells. Furthermore, Mn‐CQDs@FA/Ce6 enhanced magnetic resonance imaging (MRI) signal with an r2/r1 ratio of 5.77. Favorably, by using the Mn‐CQDs@FA delivery system, active Ce6 can reach the cellular interior while its red fluorescence (FL) and reactive oxygen species generation can be retained, as has been verified by confocal microscopy. in vitro cell viability studies verified the biocompatibility of Mn‐CQDs@FA/Ce6 nanohybrid with no significant toxicity up to 500 ppm while PDT treatment with 5 min irradiation (671 nm, 1 W cm−2) was effective in killing >90% of cells. The light‐triggered Mn‐CQDs@FA/Ce6 multifunctional hybrid can serve as a dual‐modal FL/MRI probe and as an efficient PDT agent to detect and eradicate cancer cells remotely.

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“…41 The excellent optical in vitro imaging and biocompatibility properties of the CDs conrmed that they are a compatible platform for in vivo imaging and tissue distribution. 42 The spider plant was selected as a veritable model to evaluate the in vivo imaging and tissue distribution of the CDs. Fig.…”

Section: Resultsmentioning

confidence: 99%