pH-Sensitive N-doped carbon dots–heparin and doxorubicin drug delivery system: preparation and anticancer research

Abstract

In this study, doxorubicin (DOX) hydrochloride as a model drug, N-doped carbon dots as a drug carrier, and heparin as an auxiliary medicine were selected to design and prepare a multi-functional drug delivery system with pH-triggered drug release.

Black Phosphorus Quantum Dots Gated, Carbon‐Coated Fe3O4 Nanocapsules (BPQDs@ss‐Fe3O4@C) with Low Premature Release Could Enable Imaging‐Guided Cancer Combination Therapy

“…To demonstrate the drug loading ability of ss‐Fe 3 O 4 @C NPs, we conjugated DOX using physicochemical interactions in the way of (π–π) stacking, hydrophobic and electrostatic interactions. As shown in Figure S3 D, the surface zeta potential of ss‐Fe 3 O 4 @C NPs changed from −20.8 to −9.2 mV after conjugation with DOX.…”

“…In addition, we reported a new strategy of incorporating DOX inside the HCs instead of binding it to the surface of BPQDs@DOX@ss‐Fe 3 O 4 @C‐EGFR NPs . Furthermore, the drug release behavior of BPQDs@DOX@ss‐Fe 3 O 4 @C‐EGFR NPs was investigated.…”

“…Furthermore,t he intensity of the absorption band at 1710 cm À1 was significantly reduced, indicating the formation of amide structure after graftingc ystamine dihydrochloride when most-COOH groups in the carboxy-terminated Fe 3 O 4 @C NPs consumed. [31] Figure 3D To demonstrate the drug loading ability of ss-Fe 3 O 4 @C NPs, we conjugated DOX using physicochemical interactions in the way of (p-p)s tacking, [32] hydrophobic and electrostatic interactions. As shown in FigureS3D,t he surfacez eta potential of ss-Fe 3 O 4 @C NPs changed from À20.8 to À9.2 mV after conjugation with DOX.…”

“…In addition, we reported an ew strategyo fi ncorporating DOX inside the HCs insteado fb inding it to the surfaceo f BPQDs@DOX@ss-Fe 3 O 4 @C-EGFR NPs. [32] Furthermore, the drug releaseb ehavior of BPQDs@DOX@ss-Fe 3 O 4 @C-EGFR NPs was investigated.T he load and release process of DOX is illustrated in Figure 4A.T or elease behavior of DOX promoted by GSH, pH, and NIR, the recovery characteristic absorption of DOX from BPQDs@DOX@ss-Fe 3 O 4 @C-EGFR NPs was determined. Thankst ot he feature of GSH concentration in the extracellular fluid (< 10 mm)o rt he cytosol( 1-10 mm), [40] BPQDs@DOX@ss-Fe 3 O 4 @C-EGFR NPs was highly anti-interferential against bio-logical complexes.I na ddition, minimum drug escape in the circulatory system was expected.…”

Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe₃O₄ carbon dots with graphitic black phosphorus quantum dots

“…With the development of nanobiotechnology, it is feasible to design multifunctional nanostructured materials that can simultaneously diagnose and treat cancers via the integration of molecular imaging and therapy technologies. [1][2][3][4][5] The integration of diagnosis and treatment, which can improve the survival rate and quality of life among postoperative patients, has provided an attractive avenue for detecting and treating cancer. Imaging-guided photothermal therapy (PTT), which is a novel therapeutic method of precision therapy, can be used to eliminate residual cancer cells completely with precise guidance in the future.…”