Rapid Fabrication of Composite Hydrogel Microfibers for Weavable and Sustainable Antibacterial Applications

Chen, Chuntao; Zhang, Ting; Dai, Beibei; Zhang, Heng; Chen, Xiao; Yang, Jiazhi; Liu, Jian; Sun, Dongping

doi:10.1021/acssuschemeng.6b01351

Cited by 53 publications

(28 citation statements)

References 56 publications

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“…The inhibition zone observed with the best performing sample well justifies the high bacteria-killing activity of the Ag/BC composite, as observed by the other researchers. 27 , 28 , 42 , 44 As we already discussed, pure BC is useful as a natural wound dressing material because it can provide a highly moist environment due to higher water-retention capability that prevents dehydration of tissues and cell death, resulting in faster skin repair. But pure BC does not show antibacterial activity to prevent infections in the affected area.…”

Section: Results and Discussionmentioning

confidence: 99%

Silver-Functionalized Bacterial Cellulose as Antibacterial Membrane for Wound-Healing Applications

Pal

Nisi

Stoppa³

et al. 2017

ACS Omega

193

127

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Bacterial cellulose (BC) functionalized with silver nanoparticles (AgNPs) is evaluated as an antimicrobial membrane for wound-healing treatment. A facile green synthesis of silver nanoparticles inside the porous three-dimensional weblike BC network has been obtained by UV light irradiation. AgNPs were photochemically deposited onto the BC gel network as well as they were chemically bonded to the cellulose fiber surfaces. AgNPs with a narrow size distribution along with some aggregates in the BC network were evidenced from the morphological analyses. A highly crystalline nature of the BC membranes was observed in X-ray diffraction measurements, and the presence of metallic silver confirmed the photochemical reduction of Ag+ → Ag0 in Ag/BC composites. Antibacterial activity of the hybrid composites, such as pellicles, performed against the Gram-negative bacteria (Escherichia coli) by disk diffusion and growth dynamics methods showed high bacteria-killing performance. No significant amount of silver release was observed from the Ag/BC pellicles even after a long soaking time. As composite pellicles are preserved in a moist environment that also favors wound recovery, by combining all of these properties the material could be useful in wound-healing treatments.

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Section: Results and Discussionmentioning

confidence: 99%

Silver-Functionalized Bacterial Cellulose as Antibacterial Membrane for Wound-Healing Applications

Pal

Nisi

Stoppa³

et al. 2017

ACS Omega

193

127

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“…On the contrary, BC structures with enhanced porosity presented a greater WHC value. BC synthesized in the presence of carboxymethylcellulose (CMC) in the culture media revealed a network with broader ribbons, due to the adhesion of CMC into the surface of BC fibrils, with greater WHC (Chen et al ., ). An increased pore size distribution was also found in a BC structure with loose fibril arrangement (Grande et al ., ), which corresponded to a greater WHC value (Seifert et al ., ; Yu et al ., ).…”

Section: Intrinsic Features Of Bacterial Cellulosementioning

confidence: 99%

Bacterial cellulose: a versatile biopolymer for wound dressing applications

Portela

Leal

Almeida

et al. 2019

Microbial Biotechnology

435

271

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Summary Although several therapeutic approaches are available for wound and burn treatment and much progress has been made in this area, room for improvement still exists, driven by the urgent need of better strategies to accelerate wound healing and recovery, mostly for cases of severe burned patients. Bacterial cellulose (BC) is a biopolymer produced by bacteria with several advantages over vegetal cellulose, such as purity, high porosity, permeability to liquid and gases, elevated water uptake capacity and mechanical robustness. Besides its biocompatibility, BC can be modified in order to acquire antibacterial response and possible local drug delivery features. Due to its intrinsic versatility, BC is the perfect example of a biotechnological response to a clinical problem. In this review, we assess the BC main features and emphasis is given to a specific biomedical application: wound dressings. The production process and the physical–chemical properties that entitle this material to be used as wound dressing namely for burn healing are highlighted. An overview of the most common BC composites and their enhanced properties, in particular physical and biological, is provided, including the different production processes. A particular focus is given to the biochemistry and genetic manipulation of BC. A summary of the current marketed BC‐based wound dressing products is presented, and finally, future perspectives for the usage of BC as wound dressing are foreseen.

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“…As for other gels, metallogels have been the focus of biological applications such as drug delivery, anti‐inflammation, biosensors, wound healing, etc., for many years. Introducing metal moieties into a gel may induce useful properties such as electroconductivity and light‐emitting ability to some biocompatible soft systems.…”

Section: Fundamental Applications Of Metallogelsmentioning

confidence: 99%

“…Biocompatible gels with slow drug release properties are a good choice for incorporation of antibacterial metal components . In addition to silver, there are also other metal ions or metal NPs exhibiting antibacterial activities . For instance, James et al designed a molecule, Zn(Bipy‐(MMOES) 2 ) (Figure , compound 15) which can polymerize into a homopolymer itself and act as cross‐linker for polymeric materials such as acrylic acid (AA).…”

Section: Fundamental Applications Of Metallogelsmentioning

confidence: 99%

“…Riboflavin is also a good choice for reducing metal ions, mixing AgNO 3 and a riboflavin/melamine complex followed by heating the system to 90 °C resulted the formation of a AgNPs hydrogel. And, with sodium citrate as the reducing agent, Sun and co‐workers fabricated a core–shell graphene oxide‐AgNPs/bacterial cellulose (GO–AgNP/BC) hydrogel, which exhibits excellent long‐lasting antibacterial performance.…”

Section: Fundamental Applications Of Metallogelsmentioning

confidence: 99%

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Metallogels: Availability, Applicability, and Advanceability

et al. 2019

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amount of cross-linked solid. According to the nature of solvents, gels are categorized into hydrogel and organogel to indicate whether the solvent is water or organic solvent(s), respectively. As to the gelation driving forces, gels can be classified into physical gels in which intermolecular interactions are responsible for gel formation, and chemical gels in which the gel skeleton is cross-linked by covalent bonds.Incorporation of metal components (metal ions, metal-organic molecules, and metal nanoparticles) is an effective way to locally establish extra interactions among the building blocks and consequently trigger gel formation, [2][3][4] weaken [5] or enhance [6] gel strength, and modify gel morphology. [7,8] Moreover, addition of metal components is a straightforward way to integrate the specific properties of metals with the properties of organic matrix, therefore to tune properties like conductivity, [9] color, [10,11] rheological behavior, [12] adsorption, [13] emission, [14] photophysical properties, [15] magnetism, [16,17] antibacterial activities, [18,19] catalytic activities, [20][21][22][23] redox activities, [24,25] and selfhealing properties. [26][27][28] Therefore, a broad response range to physical and chemical stimuli can be achieved. For instance, the incorporation of multivalence ions such as Fe 2+ /Fe 3+ , [25,29] Co 2+ / Co 3+ , [30] Cu + /Cu 2+ , [31] results in redox reactive hydrogels; the incorporation of magnetic nanoparticles like Fe 3 O 4[17] causes the gel to respond to external magnetic fields. In addition to the abovementioned intrinsically functional superiorities, metallogels can also serve as ideal templates to generate new materials, [13,22,23,32,33] such as 3D networks, [34] porous structures, [35] chiral materials, [36][37][38] quantum dots, [39] and nanorods. [40] Following the rapid advancement of exploration on the knowledge acquisition toward the major roles that metallogels are playing in catalysis, sensing, biomedicine, electronics, and optical devices, the focus of research has been transferred to the design principles of metallogels in the last decade. Owing to the advancements in the instrumental characterizations and theoretical calculations, [41] a number of pioneering efforts on metallogel design have been made and several innovative reviews have summarized these inspiring contributions. [32,[42][43][44] Despite their extensively acknowledged application advantages in many fields, the discovery of new metallogels with expected functionalities is still highly dependent on experimental screening and serendipity. The challenge stems from the susceptible balance among those complicated intermolecular interactions and the elaborate structure requirements of metallogels.Another research niche that needs to be clarified before discussing recent development of metallogels is: how to sort Introducing metal components into gel matrices provides an effective strategy to develop soft materials with advantageous properties such as: optical activity, conductivity, magn...

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Rapid Fabrication of Composite Hydrogel Microfibers for Weavable and Sustainable Antibacterial Applications

Cited by 53 publications

References 56 publications

Silver-Functionalized Bacterial Cellulose as Antibacterial Membrane for Wound-Healing Applications

Silver-Functionalized Bacterial Cellulose as Antibacterial Membrane for Wound-Healing Applications

Bacterial cellulose: a versatile biopolymer for wound dressing applications

Metallogels: Availability, Applicability, and Advanceability

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