Rapid hemostasis and high bioactivity cerium‐containing mesoporous bioglass for hemostatic materials

Liu, Jiaxi; Zhou, Xiang; Zhang, Yin; Wang, Anping; Zhu, Wei; Xu, Meijia; Zhuang, Shuxian

doi:10.1002/jbm.b.34996

Cited by 13 publications

(4 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The measured negative zeta potential can be associated with silanol groups on the surface of the sol–gel‐derived bioglasses. [ 39 ] It is known that negative surface charge facilitates apatite accumulation with the tendency to attract cations such as Ca 2+ , and a zeta potential of >±25 mV is resistant to aggregation. [ 40 ] In addition, it has been stated that negative zeta potential has a significant influence on osteoblastic cells.…”

Section: Resultsmentioning

confidence: 99%

Decellularized Bone Matrix/45S5 Bioactive Glass Biocomposite Hydrogel‐Based Constructs with Angiogenic and Osteogenic Properties: Ex Ovo and Ex Vivo Evaluations

Aytekin,

Vurat,

Elçin

et al. 2023

Macromolecular Bioscience

View full text Add to dashboard Cite

Decellularized extracellular matrix is often used to create an in vivo‐like environment that supports cell growth and proliferation, as it reflects the micro/macrostructure and molecular composition of tissues. On the other hand, bioactive glasses (BG) are surface‐reactive glass‐ceramics that can convert to hydroxyapatite in vivo and promote new bone formation. This study is designed to evaluate the key properties of a novel angiogenic and osteogenic biocomposite graft made of bovine decellularized bone matrix (DBM) hydrogel and 45S5 BG microparticles (10 and 20 wt%) to combine the existing superior properties of both biomaterial classes. Morphological, physicochemical, mechanical, and thermal characterizations of DBM and DBM/BG composite hydrogels are performed. Their in vitro biocompatibility is confirmed by cytotoxicity and hemocompatibility analyses. Ex vivo chick embryo aortic arch and ex ovo chick chorioallantoic membrane (CAM) assays reveal that the present pro‐angiogenic property of DBM hydrogels is enhanced by the incorporation of BG. Histochemical stainings (Alcian blue and Alizarin red) and digital image analysis of ossification on hind limbs of embryos used in the CAM model reveal the osteogenic potential of biomaterials. The findings support the notion that the developed DBM/BG composite hydrogel constructs have the potential to be a suitable graft for bone repair.

show abstract

Section: Resultsmentioning

confidence: 99%

Decellularized Bone Matrix/45S5 Bioactive Glass Biocomposite Hydrogel‐Based Constructs with Angiogenic and Osteogenic Properties: Ex Ovo and Ex Vivo Evaluations

Aytekin,

Vurat,

Elçin

et al. 2023

Macromolecular Bioscience

View full text Add to dashboard Cite

show abstract

“…Our study aims to develop hemostatic materials using naturally derived biomaterials due to their good hydrophilicity and abundant supply of raw materials. Naturally derived biomaterials such as gelatin, [ 5 ] bioglass, [ 6 ] zeolite, [ 7 ] alginate, chitosan, cellulose, [ 8 ] and collagen [ 9 ] have been widely used for developing hemostatic materials. Many forms of hemostatic materials, for example, electrospun nanofibers, hydrogels, [ 10 ] sponges, [ 5 , 11 ] micro/nanoparticles, [ 12 ] non‐woven fabrics, [ 13 ] and microneedles [ 14 ] have been developed and made some achievements.…”

Section: Introductionmentioning

confidence: 99%

Carbonized Cellulose Aerogel Derived from Waste Pomelo Peel for Rapid Hemostasis of Trauma‐Induced Bleeding

Wan,

Feng,

Tan

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Uncontrollable massive bleeding caused by trauma will cause the patient to lose a large amount of blood and drop body temperature quickly, resulting in hemorrhagic shock. This study aims to develop a hemostatic product for hemorrhage management. In this study, waste pomelo peel as raw material is chosen. It underwent processes of carbonization, purification, and freeze‐drying. The obtained carbonized pomelo peel (CPP) is hydrophilic and exhibits a porous structure (nearly 80% porosity). The water/blood absorption ratio is significantly faster than the commercial Gelfoam and has a similar water/blood absorption capacity. In addition, the CPP showed a water‐triggered shape‐recoverable ability. Moreover, the CPP shows ideal cytocompatibility and blood compatibility in vitro and favorable tissue compatibility after long terms of subcutaneous implantation. Furthermore, CPP can absorb red blood cells and fibrin. It also can absorb platelets and activate platelets, and it is capable of achieving rapid hemostasis on the rat tail amputation and hepatectomized hemorrhage model. In addition, the CPP not only can quickly stop bleeding in the rat liver‐perforation and rabbit heart uncontrolled hemorrhage models, but also promotes rat liver and rabbit heart tissue regeneration in situ. These results suggest the CPP has shown great potential for managing uncontrolled hemorrhage.

show abstract

“…Liu J et al synthesized cerium-containing spherical mesoporous bioglass particles, effectively reducing the clotting time and promoting cell proliferation. The results were arrived at by conducting in vitro tests 177 . Magnesium ions significantly affect the processes of cell adhesion, proliferation, and mineralization 178 .…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the medical applications of hemostatic materials

Yu¹,

Wang²,

Liu³

et al. 2023

Theranostics

View full text Add to dashboard Cite

Bleeding caused by trauma or surgery is a serious health problem, and uncontrollable bleeding can result in death. Therefore, developing safe, effective, and convenient hemostatic materials is important. Active hemostatic agents currently used to investigate the field of hemostasis are divided into four broad categories: natural polymers, synthetic polymers, inorganic materials, and metal-containing materials. Hemostatic materials are prepared in various forms for wound care applications based on the active ingredients used. These materials include nanofibers, gels, sponges, and nanoparticles. Hemostatic materials find their applications in the field of wound care, and they are also used for hemostasis during malignant tumor surgery. Prompt and effective hemostasis can reduce the possibility of the spread of tumor cells with blood. This review discusses the outcomes of current research conducted in the field and the problems persisting in the field of developing hemostatic materials. The review also presents a platform for the further development of hemostatic materials. Bleeding caused by trauma or surgery is a serious health problem, and uncontrollable bleeding can result in death. Therefore, developing safe, effective, and convenient hemostatic materials is important. Active hemostatic agents currently used to investigate the field of hemostasis are divided into four broad categories: natural polymers, synthetic polymers, inorganic materials, and metal-containing materials. Hemostatic materials are prepared in various forms for wound care applications based on the active ingredients used. These materials include nanofibers, gels, sponges, and nanoparticles. Hemostatic materials find their applications in the field of wound care, and they are also used for hemostasis during malignant tumor surgery. Prompt and effective hemostasis can reduce the possibility of the spread of tumor cells with blood. This review discusses the outcomes of current research conducted in the field and the problems persisting in the field of developing hemostatic materials. The review also presents a platform for the further development of hemostatic materials.

show abstract

Rapid hemostasis and high bioactivity cerium‐containing mesoporous bioglass for hemostatic materials

Cited by 13 publications

References 38 publications

Decellularized Bone Matrix/45S5 Bioactive Glass Biocomposite Hydrogel‐Based Constructs with Angiogenic and Osteogenic Properties: Ex Ovo and Ex Vivo Evaluations

Decellularized Bone Matrix/45S5 Bioactive Glass Biocomposite Hydrogel‐Based Constructs with Angiogenic and Osteogenic Properties: Ex Ovo and Ex Vivo Evaluations

Carbonized Cellulose Aerogel Derived from Waste Pomelo Peel for Rapid Hemostasis of Trauma‐Induced Bleeding

Recent advances in the medical applications of hemostatic materials

Contact Info

Product

Resources

About