Rapid HPLC screening method for contaminants found in implicatedL-tryptophan associated with eosinophilia myalgia syndrome and adulterated rapeseed oil associated with toxic oil syndrome

Williamson, B.; Tomlinson, Andy J.; Hurth, Kyle; Paz, Manuel Posada de la; Gleich, Gerald J.; Naylor, Stephen

doi:10.1002/(sici)1099-0801(199809/10)12:5<255::aid-bmc743>3.0.co;2-e

Cited by 10 publications

(1 citation statement)

References 28 publications

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“…These usually result in gastroenteritis, but more severe problems have been reported, such as eosinophilia-myalgia syndrome and death due to unknown chemical contamination of L-tryptophan supplements [9, 38–40]. Chinese herbal products have been reported to be contaminated with toxic herbs such as podophyllum and Datura metel [41].…”

Section: When To Anticipate Adverse Effects and Toxicitiesmentioning

confidence: 99%

Dietary supplements and herbal medicine toxicities—when to anticipate them and how to manage them

2009

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BackgroundDietary supplements and herbal medicines are gaining popularity in many developed countries.AimsAlthough most can be used without any problem, serious toxicities do occur.MethodsProblems can be anticipated when they are used for non-traditional indications, at excessive dose, for prolonged duration, or by patients who are also on multiple modern pharmaceuticals. Problems should also be anticipated when these products claim to be able to relieve symptoms rapidly or when herbs with pronounced pharmacological effects or toxic components are used.ResultsResuscitation, symptomatic and supportive care are the most important aspects of management of toxicities from these products.ConclusionThis article reviews when problems with these products can be anticipated and outlines a practical approach to management.

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Section: When To Anticipate Adverse Effects and Toxicitiesmentioning

confidence: 99%