Rapid in situ endothelialization of a small diameter vascular graft with catalytic nitric oxide generation and promoted endothelial cell adhesion

Wang, Yuanyuan; Chen, Siyuan; Pan, Yinming; Gao, Jingchen; Tang, Di; Wang, Shufang

doi:10.1039/c5tb02080h

Cited by 44 publications

(30 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20,108–113 Many researchers have later unveiled NO’s various physiological functions in the human body, including preventing platelet activation and adhesion, inhibiting bacterial proliferation and biofilm formation, enhancing endothelization, signaling in the immune system’s response, and promoting angiogenesis and the wound healing process. 112,114–117 …”

Section: Nitric Oxide (No) To the Rescuementioning

confidence: 99%

“…The NO-releasing grafts were found to be substantially less thrombogenic than the controls, suggesting considerable promise for this approach to improve the performance of vascular graft after implantation. 239 The West 115 and Wang 114 groups both reported that NO releasing/generating grafts encourage endothelialization/endothelial cell proliferation, which can alleviate the complications of thrombosis and intimal hyperplasia (IH) that cause the failure of small diameter vascular grafts without the use of systemic anticoagulants.…”

Section: Applications Of No Releasing/generating Polymers For Preparimentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

et al. 2016

View full text Add to dashboard Cite

Biomedical devices are essential for patient diagnosis and treatment; however, when blood comes in contact with foreign surfaces or homeostasis is disrupted, complications including thrombus formation and bacterial infections can interrupt device functionality, causing false readings and/or shorten device lifetime. Here, we review some of the current approaches for developing antithrombotic and antibacterial materials for biomedical applications. Special emphasis is given to materials that release or generate low levels of nitric oxide (NO). Nitric oxide is an endogenous gas molecule that can inhibit platelet activation as well as bacterial proliferation and adhesion. Various NO delivery vehicles have been developed to improve NO’s therapeutic potential. In this review, we provide a summary of the NO releasing and NO generating polymeric materials developed to date, with a focus on the chemistry of different NO donors, the polymer preparation processes, and in vitro and in vivo applications of the two most promising types of NO donors studied thus far, N-diazeniumdiolates (NONOates) and S-nitrosothiols (RSNOs).

show abstract

Section: Nitric Oxide (No) To the Rescuementioning

confidence: 99%

Section: Applications Of No Releasing/generating Polymers For Preparimentioning

confidence: 99%

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

et al. 2016

View full text Add to dashboard Cite

show abstract

“…in the untreated. (100) Other authors have attached cell-adhesive peptides (101–105) or added cell-friendly biochemicals (102,103,105–107) to entice engraftment.…”

Section: Designs and Progressmentioning

confidence: 99%

Quickening: Translational design of resorbable synthetic vascular grafts

Stowell

Wang

2018

Biomaterials

View full text Add to dashboard Cite

Traditional tissue-engineered vascular grafts have yet to gain wide clinical use. The difficulty of scaling production of these cell- or biologic-based products has hindered commercialization. In situ tissue engineering bypasses such logistical challenges by using acellular resorbable scaffolds. Upon implant, the scaffolds become remodeled by host cells. This review describes the scientific and translational advantages of acellular, synthetic vascular grafts. It surveys in vivo results obtained with acellular synthetics over their fifty years of technological development. Finally, it discusses emerging principles, highlights strategic considerations for designers, and identifies questions needing additional research.

show abstract

“…Besides peptides such as RGD, which induce cell adhesion in general, peptide sequences have been discovered for which specific cell types have an increased affinity over other cell types, due to increased expression of the binding motif on these cells . The REDV peptide, for which endothelial cell‐specificity has been reported, attributed to binding to integrin α4β1, has been extensively applied to enhance endothelialization of biomaterials . In another approach, a peptide derived from stromal cell derived factor‐1α (SDF1α), a chemoattractant of lymphocytes, monocytes, and progenitors cells, has been applied for improved in situ cellularization…”

Section: Introductionmentioning

confidence: 99%

Combinatorial functionalization with bisurea‐peptides and antifouling bisurea additives of a supramolecular elastomeric biomaterial

Ippel

Arts

Keizer

et al. 2019

J Polym Sci B Polym Phys

View full text Add to dashboard Cite

The bioactive additive toolbox to functionalize supramolecular elastomeric materials expands rapidly. Here we have set an explorative step toward screening of complex combinatorial functionalization with antifouling and three peptide‐containing additives in a bisurea‐based supramolecular system. Thorough investigation of surface properties of thin films with contact angle measurements, X‐ray photoelectron spectroscopy and atomic force microscopy, was correlated to cell‐adhesion of endothelial and smooth muscle cells to apprehend their respective predictive values for functional biomaterial development. Peptides were presented at the surface alone, and in combinatorial functionalization with the oligo(ethylene glycol)‐based non‐cell adhesive additive. The bisurea‐RGD additive was cell‐adhesive in all conditions, whereas the endothelial cell‐specific bisurea‐REDV showed limited bioactive properties in all chemical nano‐environments. Also, aspecific functionality was observed for a bisurea‐SDF1α peptide. These results emphasize that special care should be taken in changing the chemical nano‐environment with peptide functionalization. © 2019 The Authors. Journal of Polymer Science Part B: Polymer Physics published by Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 1725–1735

show abstract

Rapid in situ endothelialization of a small diameter vascular graft with catalytic nitric oxide generation and promoted endothelial cell adhesion

Abstract: Rapidin situendothelialization of a small diameter vascular graft with catalytic nitric oxide generation and promoted endothelial cell adhesion.

Cited by 44 publications

References 55 publications

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

Quickening: Translational design of resorbable synthetic vascular grafts

Combinatorial functionalization with bisurea‐peptides and antifouling bisurea additives of a supramolecular elastomeric biomaterial

Contact Info

Product

Resources

About