Rapid In Vivo Fingerprinting of Nonvolatile Compounds in Breath by Extractive Electrospray Ionization Quadrupole Time‐of‐Flight Mass Spectrometry

Chen, Huanwen; Wortmann, Arno; Zhang, Weihua; Zenobi, Renato

doi:10.1002/anie.200602942

Cited by 199 publications

(133 citation statements)

References 39 publications

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“…EESI is not intrinsically a tool for surface analysis, because filling the sample transfer line (e.g., a fused silica capillary) requires a few M liquid sample. However, using a neutral desorption sampling technique, biological sample surfaces [5,[71][72][73][74] and the surface of a hanging liquid droplet [75] have been successfully investigated by EESI-MS. For the hanging droplet experiment, the data suggests that a volume of liquid, which is probably representative of the bulk sample is liberated using the neutral gas beam [75].…”

Section: Samples Accessible For Analysis By Ambient Ionization Technimentioning

confidence: 99%

“…However, perhaps fueled by the availability of excellent and very sensitive instrumentation and/or by the fact that the MS field has attracted many brilliant minds, the surge continued and is still continuing. In the last years, there has been a flurry of developments, most notably the introduction of sources for ambient mass spectrometry, including desorption by electrospray ionization (DESI) [2], direct analysis in real time (DART) [3], extractive electrospray ionization (EESI) [4,5], secondary electrospray ionization (SESI) [6,7], and many combinations of desorption with postionization methods working at atmospheric pressure (for a review, see [8]). No less than 25 different ambient surface desorption/postionization methods for the analysis of medium to low volatility compounds have been described in the literature in the last few years!…”

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confidence: 99%

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What can we learn from ambient ionization techniques?

Chen

Gamez

Zenobi

2009

J. Am. Soc. Mass Spectrom.

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228

178

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Ambient mass spectrometry-mass spectrometric analysis with no or minimal effort for sample preparation-has experienced a very rapid development during the last 5 years, with many different methods now available for ionization. Here, we review its range of applications, the hurdles encountered for its quantitative use, and the proposed mechanisms for ion formation. Clearly, more effort needs to be put into investigation of matrix effects, into defining representative sampling of heterogeneous materials, and into understanding and controlling the underlying ionization mechanisms. Finally, we propose a concept to reduce the number of different acronyms describing very similar embodiments of ambient mass spectrometry. (J Am Soc Mass

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Section: Samples Accessible For Analysis By Ambient Ionization Technimentioning

confidence: 99%

mentioning

confidence: 99%

What can we learn from ambient ionization techniques?

Chen

Gamez

Zenobi

2009

J. Am. Soc. Mass Spectrom.

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228

178

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“…This is one reason to test the reactive paper spray method of analysing aldehydes with both benchtop and portable mass spectrometers. Breath analysis by mass spectrometry is an area of increasing interest due to its capability for making non-invasive measurements [35][36][37] which can be used to monitor metabolic state and potentially detecting disease biomarkers [38][39][40]. It is in this context that we describe a fast, direct and reactive paper spray approach to determine aldehydes using in-situ derivatization with 4-aminophenol to produce iminium ions.…”

Section: Introductionmentioning

confidence: 99%

Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry

Bag

Hendricks

Reynolds

et al. 2015

Analytica Chimica Acta

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Ionization of aliphatic and aromatic aldehydes is improved by performing simultaneous chemical derivatization using 4-aminophenol to produce charged iminium ions during paper spray ionization.Accelerated reactions occur in the microdroplets generated during the paper spray ionization event for the tested aldehydes (formaldehyde, n-pentanaldehyde, n-nonanaldehyde, n-decanaldehyde, ndodecanaldehyde, benzaldehyde, m-anisaldehyde, and p-hydroxybenzaldehyde). Tandem mass spectrometric analysis of the iminium ions using collision-induced dissociation demonstrated that straight chain aldehydes give a characteristic fragment at m/z 122 (shown to correspond to protonated 4-(methyleneamino)phenol), while the arylaldehydeiminium ions fragment to give a characteristic product ion at m/z 120. These features allow straightforward identification of linear and aromatic aldehydes. Quantitative analysis of n-nonaldehyde using a benchtop mass spectrometer demonstrated a linear response over 3 orders of magnitude from 2.5 ng -5 µg of aldehyde loaded on the filter paper emitter. The limit of detection was determined to be 2.2 ng for this aldehyde. The method had a precision of 22%, relative standard deviation. The experiment was also implemented using a portable ion trap mass spectrometer.3

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“…Extractive electrospray ionization (EESI) has been applied for direct characterization of complex samples without sample pretreatment [12][13][14][15][16]. Herein, we establish a novel method based on nanoEESI-MS/MS implemented in a commercial LTQ-XL mass spectrometer for rapid detection of trace amount of cocaine in beverages, such as Pepsi, Coca-Cola, and Red Bull energy drinks without any sample pretreatment.…”

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confidence: 99%

Fast quantitative detection of cocaine in beverages using nanoextractive electrospray ionization tandem mass spectrometry

Hu¹,

Peng²,

Yang³

et al. 2010

J. Am. Soc. Mass Spectrom.

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Without any sample pretreatment, effervescent beverage fluids were manually sprayed into the primary ion plume created by using a nanoelectrospray ionization source for direct ionization, and the analyte ions of interest were guided into an ion trap mass spectrometer for tandem mass analysis. Functional ingredients (e.g., vitamins, taurine, and caffeine, etc.) and spiked impurity (e.g., cocaine) in various beverages, such as Red Bull energy drink, Coco-cola, and Pepsi samples were rapidly identified within 1.5 s. The limit of detection was found to be 7 ϳ 15 fg (S/N ϭ 3) for cocaine in different samples using the characteristic fragment (m/z 150) observed in the MS 3 experiments. Typical relative standard deviation and recovery of this method were 6.9% ϳ 8.6% and 104% ϳ 108% for direct analysis of three actual samples, showing that nanoextractive electrospray ionization tandem mass spectrometry is a useful technique for fast screening cocaine presence in beverages. (J Am Soc Mass Spectrom 2010, 21, 290 -293)

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Rapid In Vivo Fingerprinting of Nonvolatile Compounds in Breath by Extractive Electrospray Ionization Quadrupole Time‐of‐Flight Mass Spectrometry

Cited by 199 publications

References 39 publications

What can we learn from ambient ionization techniques?

What can we learn from ambient ionization techniques?

Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry

Fast quantitative detection of cocaine in beverages using nanoextractive electrospray ionization tandem mass spectrometry

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