2015
DOI: 10.1073/pnas.1419659112
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Rapid molecular evolution across amniotes of the IIS/TOR network

Abstract: The insulin/insulin-like signaling and target of rapamycin (IIS/TOR) network regulates lifespan and reproduction, as well as metabolic diseases, cancer, and aging. Despite its vital role in health, comparative analyses of IIS/TOR have been limited to invertebrates and mammals. We conducted an extensive evolutionary analysis of the IIS/TOR network across 66 amniotes with 18 newly generated transcriptomes from nonavian reptiles and additional available genomes/transcriptomes. We uncovered rapid and extensive mol… Show more

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Cited by 61 publications
(72 citation statements)
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“…For example, bacterial production of acetic acid and other fermentation products, as well as branched‐chain amino acids, can influence the activity of insulin‐like/target of rapamycin (IIS/TOR) signalling (Shin et al, ; Storelli et al, ). IIS/TOR signalling has a central role in regulating cell and organismal growth, as well as female fecundity, and, consequently, life history strategies (McGaugh et al, ; Oldham, ). Drosophila melanogaster life history and survival can also be influenced by bacterial consumption of glucose (Chaston et al, ; Huang & Douglas, ) or by synthesis of methionine (Judd et al, ) and B vitamins (Sannino, Dobson, Edwards, Angert, & Buchon, ; Wong, Dobson, & Douglas, ), suggesting candidate bacterial functions that may mediate shifts in D. melanogaster life history strategy.…”
Section: Discussionmentioning
confidence: 99%
“…For example, bacterial production of acetic acid and other fermentation products, as well as branched‐chain amino acids, can influence the activity of insulin‐like/target of rapamycin (IIS/TOR) signalling (Shin et al, ; Storelli et al, ). IIS/TOR signalling has a central role in regulating cell and organismal growth, as well as female fecundity, and, consequently, life history strategies (McGaugh et al, ; Oldham, ). Drosophila melanogaster life history and survival can also be influenced by bacterial consumption of glucose (Chaston et al, ; Huang & Douglas, ) or by synthesis of methionine (Judd et al, ) and B vitamins (Sannino, Dobson, Edwards, Angert, & Buchon, ; Wong, Dobson, & Douglas, ), suggesting candidate bacterial functions that may mediate shifts in D. melanogaster life history strategy.…”
Section: Discussionmentioning
confidence: 99%
“…; Swanson and Dantzer ; McGaugh et al. ; Schwartz and Bronikowski ; Zhao et al. ; and references therein).…”
Section: Discussionmentioning
confidence: 99%
“…Many of these RNA-Seq data were reported by McGaugh et al [19] and Wu et al [20]. Downloaded sra files were converted to two fastq files corresponding to forward and reverse paired-end reads, using the fastq-dump in the NCBI SRA toolkit.…”
Section: Methodsmentioning
confidence: 99%