Rapid Nanoimprinting of Silk Fibroin Films for Biophotonic Applications

Amsden, Jason J.; Domachuk, P.; Gopinath, Ashwin; White, Robert D.; Negro, Luca Dal; Kaplan, David L.; Omenetto, Fiorenzo G.

doi:10.1002/adma.200903166

Cited by 154 publications

(154 citation statements)

References 44 publications

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“…Further, silk has been shown to be suitable for use as a material platform for sophisticated optical and opto-electronic components with features on the micro-and nanoscale (7)(8)(9). The resulting free-standing devices formed from silk are refractive or diffractive and comprise elements ranging from microlens arrays and white-light holograms to diffraction gratings and planar photonic crystals with minimum feature sizes of less than 20 nm (7,9,10). These components provide mechanically stable, high-quality optical elements that are fully degradable, biocompatible, and implantable (11).…”

mentioning

confidence: 99%

Implantable, multifunctional, bioresorbable optics

Tao

Kainerstorfer

Siebert

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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114

108

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Advances in personalized medicine are symbiotic with the development of novel technologies for biomedical devices. We present an approach that combines enhanced imaging of malignancies, therapeutics, and feedback about therapeutics in a single implantable, biocompatible, and resorbable device. This confluence of form and function is accomplished by capitalizing on the unique properties of silk proteins as a mechanically robust, biocompatible, optically clear biomaterial matrix that can house, stabilize, and retain the function of therapeutic components. By developing a form of high-quality microstructured optical elements, improved imaging of malignancies and of treatment monitoring can be achieved. The results demonstrate a unique family of devices for in vitro and in vivo use that provide functional biomaterials with built-in optical signal and contrast enhancement, demonstrated here with simultaneous drug delivery and feedback about drug delivery with no adverse biological effects, all while slowly degrading to regenerate native tissue.

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mentioning

confidence: 99%

Implantable, multifunctional, bioresorbable optics

Tao

Kainerstorfer

Siebert

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

114

108

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“…135 Photonic properties can also be engineered into fibroin films by patterning them as gratings, 136 which then exhibit a specific spectral response that can be modified by submerging them in fluid, 137 or, in the case of functionalized gratings, by exposing to targeted gases. 138 …”

Section: Applications and Potential Of Synthetic Spider-like Silksmentioning

confidence: 99%

With great structure comes great functionality: Understanding and emulating spider silk

et al. 2014

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The overarching aim of biomimetic approaches to materials synthesis is to mimic simultaneously the structure and function of a natural material, in such a way that these functional properties can be systematically tailored and optimized. In the case of synthetic spider silk fibers, to date functionalities have largely focused on mechanical properties. A rapidly expanding body of literature documents this work, building on the emerging knowledge of structure-function relationships in native spider silks, and the spinning processes used to create them. Here, we describe some of the benchmark achievements reported until now, with a focus on the last five years. Progress in protein synthesis, notably the expression on full-size spidroins, has driven substantial improvements in synthetic spider silk performance. Spinning technology, however, lags behind and is a major limiting factor in biomimetic production. We also discuss applications for synthetic silk that primarily capitalize on its nonmechanical attributes, and that exploit the remarkable range of structures that can be formed from a synthetic silk feedstock.

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“…These gratings enabled sensing of proteins with sensitivity down to 5 nM by their intercalation into lipid multilayers, which lowered diffraction efficiency of the gratings. Silk has been a popular material for fabrication of optical diffractive elements [38,81,82]. Gratings are produced by pouring silk fibroin solution to a master mold, allowing it to dry, and detaching the silk layer to form a freestanding grating.…”

Section: Diffraction Grating Reflectorsmentioning

confidence: 99%

Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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Rapid Nanoimprinting of Silk Fibroin Films for Biophotonic Applications

Cited by 154 publications

References 44 publications

Implantable, multifunctional, bioresorbable optics

Implantable, multifunctional, bioresorbable optics

With great structure comes great functionality: Understanding and emulating spider silk

Toward biomaterial-based implantable photonic devices

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