Rapid Placement of Bicaval Dual-Lumen Catheter in a Swine Model of Venovenous ECMO

Hayes, Don; Yates, Andrew R.; Duffy, Vicky; Tobias, Joseph D.; Mansour, Heidi M.; Olshove, Vincent; Preston, Thomas J.

doi:10.3109/08941939.2013.826311

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…As there are no small animal models available, we could not compare these findings. Large animal ECMO models, however, showed similar oxygenation results and comparable hemodynamics but did not report renal or hepatic function parameters [15,16]. In conclusion, we present the proof-of-concept use of bi-caval double lumen ECMO in a murine model.…”

Section: Discussionmentioning

confidence: 81%

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Four hours of veno-venous extracorporeal membrane oxygenation using bi-caval cannulation affects kidney function and induces moderate lung damage in a mouse model

Natanov

Khalikov

Gueler

et al. 2019

ICMx

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Background: Improvement of single site cannulation for extracorporeal membrane oxygenation (ECMO) therapy is pivotal for reduction of patient morbidity and mortality in respiratory failure. To further improve the cardiopulmonary outcomes and reduce end organ damage, we established a murine model for single site cannulation with a double lumen cannula. Results: We created a hemodynamically stable double lumen cannula and successfully implanted it through the jugular vein into the upper and lower vena cava. This allowed adequate drainage of the blood. Blood gas analysis showed excellent oxygenation and CO 2 reduction. There was no excessive bleeding. No signs of right heart congestion were present which was confirmed in the histological analysis of the liver. Histology demonstrated moderate lung damage and mild acute kidney injury. Neutrophil infiltration was similar in ECMO and sham kidneys. Conclusions: Veno-venous extracorporeal circulation deteriorates kidney function and promotes moderate pulmonary damage.

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Section: Discussionmentioning

confidence: 81%

“…Animal models of bi-caval ECMO are rare, with to date, only two swine models being described [15,16]. To our knowledge, no papers on bi-caval double lumen ECMO in a murine model have been published, making this a novel model.…”

Section: Discussionmentioning

confidence: 99%

Four hours of veno-venous extracorporeal membrane oxygenation using bi-caval cannulation affects kidney function and induces moderate lung damage in a mouse model

Natanov

Khalikov

Gueler

et al. 2019

ICMx

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“…This is supported by evidence of increased survival and bridge to transplantation seen in V-A ECMO and PA-LA iLA patients with PA hypertension and right heart failure (20). Building on the current surgical support option, an alternative strategy is to establish the V-V support by using the bicaval dual lumen cannula, such as the Wang-Zwische patented cannula (21,22). With this cannula, the PediPL device can be used by the completely percutaneous placement, thus avoiding open-chest surgery, especially under emergency circumstances.…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal Respiratory Support With a Miniature Integrated Pediatric Pump‐Lung Device in an Acute Ovine Respiratory Failure Model

et al. 2016

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Purpose Respiratory failure is one of the major causes of mortality and morbidity all over the world. Therapeutic options to treat respiratory failure remain limited. The objective of this study was to evaluate the gas transfer performance of a new newly developed miniature portable integrated pediatric pump-lung device (PediPL) with small membrane surface for respiratory support in an acute ovine respiratory failure model. Methods The respiratory failure was created in six adult sheep using intravenous anesthesia and reduced mechanical ventilation at 2 breaths/min. The PediPL device was surgically implanted and evaluated for respiratory support in a veno-veno configuration between the right atrium and pulmonary artery. The hemodynamics and respiratory status of the animals during support with the device gas transfer performance of the PediPL were studied for four hours. Results The animals exhibited respiratory failure after 30 minutes after mechanical ventilation was reduced to 2 breaths/min, indicated by low oxygen partial pressure, low oxygen saturation and elevated carbon dioxide in arterial blood. The failure was reversed by establishing respiratory support with the PediPL after 30 minutes. The rates of O2 transfer and CO2 removal of the PediPL were 86.8 ml/min and 139.1 ml/min, respectively. Conclusions The results demonstrated that the PediPL (miniature integrated pump-oxygenator) has the potential to provide respiratory support as a novel treatment of both hypoxia and hypercarbia. The compact size of the PediPL could allow portability and potentially be used in many emergency settings to rescue patients suffering acute lung injury.

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“…Using a single cannula with a branched inflow-outflow design BCDL catheter has many advantages over the more traditional two-cannula approach [70]. Currently, the technology and development state of the single-site ECMO support is the primary restriction that is limiting wider use.…”

Section: Discussionmentioning

confidence: 99%

Veno-venous ECMO: a synopsis of nine key potential challenges, considerations, and controversies

et al. 2014

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BackgroundFollowing the 2009 H1N1 Influenza pandemic, extracorporeal membrane oxygenation (ECMO) emerged as a viable alternative in selected, severe cases of ARDS. Acute Respiratory Distress Syndrome (ARDS) is a major public health problem. Average medical costs for ARDS survivors on an annual basis are multiple times those dedicated to a healthy individual. Advances in medical and ventilatory management of severe lung injury and ARDS have improved outcomes in some patients, but these advances fail to consistently “rescue” a significant proportion of those affected.DiscussionHere we present a synopsis of the challenges, considerations, and potential controversies regarding veno-venous ECMO that will be of benefit to anesthesiologists, surgeons, and intensivists, especially those newly confronted with care of the ECMO patient. We outline a number of points related to ECMO, particularly regarding cannulation, pump/oxygenator design, anticoagulation, and intravascular fluid management of patients. We then address these challenges/considerations/controversies in the context of their potential future implications on clinical approaches to ECMO patients, focusing on the development and advancement of standardized ECMO clinical practices.SummarySince the 2009 H1N1 pandemic ECMO has gained a wider acceptance. There are challenges that still must be overcome. Further investigations of the benefits and effects of ECMO need to be undertaken in order to facilitate the implementation of this technology on a larger scale.

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Rapid Placement of Bicaval Dual-Lumen Catheter in a Swine Model of Venovenous ECMO

Abstract: Using anatomical landmarks for the placement of the BCDL catheter was rapid and effective in a swine model of VV ECMO, resulting in improved time efficiency for research.

Cited by 4 publications

References 18 publications

Four hours of veno-venous extracorporeal membrane oxygenation using bi-caval cannulation affects kidney function and induces moderate lung damage in a mouse model

Four hours of veno-venous extracorporeal membrane oxygenation using bi-caval cannulation affects kidney function and induces moderate lung damage in a mouse model

Extracorporeal Respiratory Support With a Miniature Integrated Pediatric Pump‐Lung Device in an Acute Ovine Respiratory Failure Model

Veno-venous ECMO: a synopsis of nine key potential challenges, considerations, and controversies

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