Rapid preparation of pH-sensitive polymeric nanoparticle with high loading capacity using electrospray for oral drug delivery

Amphiphilic copolymers with pendent carboxyl groups for high-efficiency loading and controlled release of doxorubicin

“…For the design of efficient drug carriers, achieving high drugloading capacity and a controllable drug-release property are the two main challenges [18,19]. In this paper, DOX-loading and zeta potentials studies have showed that the electrostatic interaction between mPEG-b-PATMC-g-SCH 2 COOH and DOX could significantly improve the loading levels.…”

“…On the other hand, achieving high drug-loading capacity and a controllable drug-release property are two main challenges for the design of efficient drug carriers [18,19]. It has been reported that the drug contents generally cannot exceed 10% in nanoparticles [20] high-dose of anticancer drugs, and thereby severe toxicity and a burden for the patients to absorb or excrete drug carrier materials [21].…”

Synthesis and characterization of monodispersed P(St-co-DMAEMA) nanoparticles as pH-sensitive drug delivery system

“…The pH-sensitive drug delivery system, which could perform controlled drug release and targeted drug delivery based on the physiological pH gradients, has gained much attention in the recent years [1][2][3][4][5][6][7]. The physiological pH gradients can be found between gastric juice and intestinal tract, between the normal tissues and some pathological sites, and between the extracellular environment and cellular compartments.…”

Researching the dose ratio in a controlled release multiple-drug delivery system: using combination therapy with porous microparticles for the treatment of Helicobacter pylori infection

“…The OMEloaded EL 100-55 nanoparticles were rst prepared as described in our previous study, 25 and the drug loading of EL 100-55 enteric nanoparticles was 43.21%. The drug-loaded porous microparticles were prepared by the addition of MTZ into the oil phase and the addition of AMO and OME enteric nanoparticles into the water phase.…”

“…19,20 In the current study, we have prepared triple-drug-loaded porous ERS microparticles for the combination therapy of H. pylori infection and found that these are more suitable for clinical practice. 25 The physicochemical characteristics of the triple-drug-loaded porous microparticles generated by emulsion electrospray were examined, and single-photon emission computed tomography (SPECT) was employed to investigate the in vivo oating behavior of the porous microparticles in rabbits. 23 An experiential triple therapy regimen including 40 mg of omeprazole (OME), 400 mg of metronidazole (MTZ), and 1 g of amoxicillin sodium (AMO) was selected for use in this study.…”