Rapid prototyping in tissue engineering: challenges and potential

Yeong, Wai Yee; Chua, Chee Kai; Leong, Kah Fai; Chandrasekaran, M.

doi:10.1016/j.tibtech.2004.10.004

Cited by 744 publications

(519 citation statements)

References 75 publications

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“…[1][2][3][4] Owing to their capacity to build custom-made 3D structures, RP techniques have arisen special interest within the regenerative medicine community. In addition to revolutionize implantology and regenerative therapies by introducing new possibilities to reconstruct and regenerate tissues in a patient-specific manner, RP also provides a tremendous tool to fabricate scaffolds on demand to obtain in vitro platforms for studying the effect of various parameters such as scaffolds architecture, pore size, geometry, topography, wettability, and mechanical properties among others, on cells behavior including inflammatory response.…”

Section: D Printed Pla-based Scaffoldsmentioning

confidence: 99%

3D printed PLA-based scaffolds

et al. 2013

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Section: D Printed Pla-based Scaffoldsmentioning

confidence: 99%

3D printed PLA-based scaffolds

et al. 2013

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“…The level of control over the microstructure of the SLS parts is dependent on the process parameters (laser power, scan speed and spot diameter of the laser beam, and bed temperature) and the powder properties. The particle shape and size distribution influence the powder packing density, while the melting flow behavior and the thermal stability define the laser power and scan speed [13][14][15][16][17][18][19]. In recent years, the SLS process has shown great prominence in the medical field, such as in the manufacturing of drug delivery devices (DDDs) [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

3D printing of PCL/Fluorouracil tablets by selective laser sintering: Properties of implantable drug delivery for cartilage cancer treatment

Gv¹,

Fe²,

Gb³

et al. 2017

Rheumatol Orthop Med

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In this study, implantable polycaprolactone/fluorouracil tablets were additively manufactured by selective laser sintering using different laser power levels. PCL/FU tablets showed on SEM-EDS small particles of fluorouracil dispersed on the surface and into the porous PCL matrix. The crystallinity values for the PCL/FU tablets were lower than for the pure PCL tablets, probably due to interaction of the FU particles with the polymer chains during the solidification process. The PCL/FU tablets prepared using the higher laser power (7 W) had the highest flexural modulus, probably due to better PCL particle coalescence, higher sinter degree and the dispersion of FU particles in the co-continuous porous PCL matrix. Initially the PCL/FU tablets provided a rapid release of a high concentration of the drug at the site of the cancer cells and a subsequent controlled release sustaining levels of the chemotherapeutic agent in the region of the tumor. This 2-stage release of the drug can be a desirable profile in cartilage cancer treatment.

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“…In contrast, the indirect printing method it is ideally suited for the controlled creation of the highly organized, aligned micro‐architecture and patient specific geometries that cardiac tissue engineering requires that cannot be generated with the traditional methods, such as solvent casting and particle leaching 12, 13, 14, 15…”

Section: Introductionmentioning

confidence: 99%

Indirect three‐dimensional printing: A method for fabricating polyurethane‐urea based cardiac scaffolds

Hernández‐Córdova

Mathew

Balint

et al. 2016

J. Biomed. Mater. Res.

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Biomaterial scaffolds are a key part of cardiac tissue engineering therapies. The group has recently synthesized a novel polycaprolactone based polyurethane‐urea copolymer that showed improved mechanical properties compared with its previously published counterparts. The aim of this study was to explore whether indirect three‐dimensional (3D) printing could provide a means to fabricate this novel, biodegradable polymer into a scaffold suitable for cardiac tissue engineering. Indirect 3D printing was carried out through printing water dissolvable poly(vinyl alcohol) porogens in three different sizes based on a wood‐stack model, into which a polyurethane‐urea solution was pressure injected. The porogens were removed, leading to soft polyurethane‐urea scaffolds with regular tubular pores. The scaffolds were characterized for their compressive and tensile mechanical behavior; and their degradation was monitored for 12 months under simulated physiological conditions. Their compatibility with cardiac myocytes and performance in novel cardiac engineering‐related techniques, such as aggregate seeding and bi‐directional perfusion, was also assessed. The scaffolds were found to have mechanical properties similar to cardiac tissue, and good biocompatibility with cardiac myocytes. Furthermore, the incorporated cells preserved their phenotype with no signs of de‐differentiation. The constructs worked well in perfusion experiments, showing enhanced seeding efficiency. © 2016 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1912–1921, 2016.

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Rapid prototyping in tissue engineering: challenges and potential

Cited by 744 publications

References 75 publications

3D printed PLA-based scaffolds

3D printed PLA-based scaffolds

3D printing of PCL/Fluorouracil tablets by selective laser sintering: Properties of implantable drug delivery for cartilage cancer treatment

Indirect three‐dimensional printing: A method for fabricating polyurethane‐urea based cardiac scaffolds

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