Rapid prototyping of ossicular replacement prostheses

Ovsianikov, Aleksandr; Chichkov, Boris N.; Adunka, Oliver F.; Pillsbury, Harold C.; Doraiswamy, Anand; Narayan, Roger J.

doi:10.1016/j.apsusc.2007.01.062

Cited by 71 publications

(52 citation statements)

References 27 publications

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“…Recently, two-photon polymerization was used to create ossicular replacement prostheses and other medical devices with a larger range of sizes, shapes and materials than previously demonstrated with other microfabrication techniques. [19] We use two-photon polymerization to precisely control the pore size of a 3D matrix. The technique permits control of architectural parameters like pore size, shape, porosity and permeability down to the submicrometer scale.…”

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confidence: 99%

3D Cell‐Migration Studies using Two‐Photon Engineered Polymer Scaffolds

et al. 2008

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confidence: 99%

3D Cell‐Migration Studies using Two‐Photon Engineered Polymer Scaffolds

et al. 2008

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“…With the variability of the technology, several applications have emerged, e.g., in the field of micro-optics, where the fabrication of photonic crystals 8,9 or micro-optical elements [10][11][12][13] has been demonstrated. Furthermore, biomedical devices like scaffolds for cell growth [14][15][16][17] or small prostheses 18 could be realized. Despite the ongoing progress in the field of 2PP, it remains challenging to preserve sub-100 nm feature sizes for complex three-dimensional microstructures with several 10 lm in height.…”

Section: Introductionmentioning

confidence: 99%

Materials and technologies for fabrication of three-dimensional microstructures with sub-100 nm feature sizes by two-photon polymerization

Burmeister

Steenhusen

Houbertz

et al. 2012

Journal of Laser Applications

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The fabrication of sub-100 nm feature sizes in large-scale three-dimensional (3D) geometries by two-photon polymerization requires a precise control of the polymeric reactions as well as of the intensity distribution of the ultrashort laser pulses. The authors, therefore, investigate the complex interplay of photoresist, processing parameters, and focusing optics. New types of inorganic– organic hybrid polymers are synthesized and characterized with respect to achievable structure sizes and their degree of crosslinking. For maintaining diffraction-limited focal conditions within the 3D processing region, a special hybrid optics is developed, where spatial and chromatic aberrations are compensated by a diffractive optical element. Feature sizes below 100 nm are demonstrated.

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“…For example, Ovsianikov et al prepared ossicular replacement prostheses, which serve as replacements for the middle ear bones, out of organically modified ceramic material using two-photon polymerization [105]. The head of the two-photon polymerization-fabricated prosthesis contained five conical structures, which may serve to enhance cell attachment and minimize prosthesis migration.…”

Section: Two-photon Polymerizationmentioning

confidence: 99%

Laser Engineering of Surface Structures

Narayan

Goering

Balani³

et al. 2014

Biosurfaces

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Over the past half century, rapid progress has been made in laser-based medical diagnosis and treatment, as well as in laser-based medical device fabrication. Lasers have unique capabilities for coating, machining, melting, polymerizing, sintering, and welding materials that are used in implantable and transdermal medical devices. In this review, academic and industrial developments involving laser processing of materials for dental, orthopedic, neural, ophthalmic, cardiovascular and transdermal applications are described. In addition, laser processing of nanoscale materials for medical applications is discussed. Finally, the challenges associated with commercialization of laser biomaterials are considered. Due to the unique capabilities provided by laser-based processes, it is anticipated that the use of laser biomaterials in implantable and transdermal medical devices will markedly increase over the coming years.

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Rapid prototyping of ossicular replacement prostheses

Cited by 71 publications

References 27 publications

3D Cell‐Migration Studies using Two‐Photon Engineered Polymer Scaffolds

3D Cell‐Migration Studies using Two‐Photon Engineered Polymer Scaffolds

Materials and technologies for fabrication of three-dimensional microstructures with sub-100 nm feature sizes by two-photon polymerization

Laser Engineering of Surface Structures

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