Rapid prototyping of scaphoid and lunate bones

Gittard, Shaun D.; Narayan, Roger J.; Lusk, Jason; Morel, Pierre; Stockmans, Filip; Ramsey, Michael L.; Laverde, Claire; Phillips, J. R.; Monteiro‐Riviere, Nancy A.; Ovsianikov, Aleksandr; Chichkov, Boris N.

doi:10.1002/biot.200800233

Cited by 43 publications

(21 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This system uses computer models to precisely guide light from a 150 W halogen bulb over a photocurable material, resulting in the selective polymerization of the exposed material. Eshell 200 acrylate-based polymer (Envision-TEC GmbH) was utilized as the constituent material to fabricate the microneedle arrays since the resin selectively polymerizes under visible light and exhibits a Youngs modulus of elasticity of 3050 AE 90 MPa [33]. Moreover, the polymer features Class-IIa biocompatibility per ISO 10993.…”

Section: Fabrication Of the Solid And Hollow Microneedle Arraysmentioning

confidence: 99%

Bicomponent Microneedle Array Biosensor for Minimally‐Invasive Glutamate Monitoring

et al. 2011

Self Cite

View full text Add to dashboard Cite

This article describes the design of a new and attractive minimally-invasive bicomponent microneedle sensing device for the electrochemical monitoring of the excitatory neurotransmitter glutamate and glucose. The new device architecture relies on the close integration of solid and hollow microneedles into a single biosensor array device containing multiple microcavities. Such microcavities facilitate the electropolymeric entrapment of the recognition enzyme within each microrecess. The resulting microneedle biosensor array can be employed as a minimallyinvasive on-body transdermal patch, obviating the extraction/sampling of the biological fluid, thereby simplifying device requirements. The new concept is demonstrated for the electropolymeric entrapment of glutamate oxidase and glucose oxidase within a poly(o-phenylenediamine) (PPD) thin film. The PPD-based enzyme entrapment methodology enables the effective rejection of coexisting electroactive interferents without compromising the sensitivity or response time of the device. The resulting microneedle-based glutamate and glucose biosensors thus exhibit high selectivity, sensitivity, speed, and stability in both buffer and undiluted human serum. High-fidelity glutamate measurements down to the 10 mM level are obtained in serum. The attractive recess design also serves to protect the enzyme layer upon insertion into the skin. This simple, yet robust microneedle design is well-suited for diverse biosensing applications in which real-time metabolite monitoring is a core requirement.

show abstract

Section: Fabrication Of the Solid And Hollow Microneedle Arraysmentioning

confidence: 99%

Bicomponent Microneedle Array Biosensor for Minimally‐Invasive Glutamate Monitoring

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…For example, Sun et al used a digital micromirror device-based stereolithography system to prepare three-dimensional microscale structures, including a matrix and a microspring array with minimum feature size of 0.6 m. 38 Gittard et al utilized digital micromirror device-based stereolithography to prepare scaphoid and lunate bone prostheses from computed tomography data; the prostheses exhibited ϳ50-mm-thick layers. 39 In this study, the minimum compressive force to obtain fracture was 1248 N for the lunate prosthesis and 1360 N for the scaphoid prosthesis. Han et al used digital micromirror device-based stereolithography to create multilayered scaffolds out of a resin containing poly͑ethylene glycol͒ diacrylate and fibronectin; attachment of murine marrow-derived progenitor cells to fibronectin-containing scaffolds was demonstrated.…”

mentioning

confidence: 59%

“…Energy-dispersive x-ray spectroscopy indicated that e-Shell 200 contains carbon, oxygen, and titanium; these elements are known to possess excellent biocompatibility. 39 According to technical data supplied by the manufacturer, e-Shell 200 exhibits a water absorption value of 0.12% ͑D570-98 test method͒ and a glass transition temperature of 109°C ͑E1545-00 test method͒. It exhibits tensile strength of 57.…”

mentioning

confidence: 99%

Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing

et al. 2011

Self Cite

View full text Add to dashboard Cite

In this study, carbon fiber electrodes were incorporated within a hollow microneedle array, which was fabricated using a digital micromirror device-based stereolithography instrument. Cell proliferation on the acrylate-based polymer used in microneedle fabrication was examined with human dermal fibroblasts and neonatal human epidermal keratinocytes. Studies involving full-thickness cadaveric porcine skin and trypan blue dye demonstrated that the hollow microneedles remained intact after puncturing the outermost layer of cadaveric porcine skin. The carbon fibers underwent chemical modification in order to enable detection of hydrogen peroxide and ascorbic acid; electrochemical measurements were demonstrated using integrated electrode-hollow microneedle devices.

show abstract

“…Major experiments have been performed to test their application in numerous surgical procedures, including bone and joint reconstruction (20,21) and cranioplasty or facial reconstruction, usually after traffic accidents (22,23).…”

Section: Direct Manufacture Of Implantable Devices For Hard-tissue Rementioning

confidence: 99%

Rapid Prototyping for Biomedical Engineering: Current Capabilities and Challenges

Lantada

Morgado

2012

Annu. Rev. Biomed. Eng.

152

View full text Add to dashboard Cite

A new set of manufacturing technologies has emerged in the past decades to address market requirements in a customized way and to provide support for research tasks that require prototypes. These new techniques and technologies are usually referred to as rapid prototyping and manufacturing technologies, and they allow prototypes to be produced in a wide range of materials with remarkable precision in a couple of hours. Although they have been rapidly incorporated into product development methodologies, they are still under development, and their applications in bioengineering are continuously evolving. Rapid prototyping and manufacturing technologies can be of assistance in every stage of the development process of novel biodevices, to address various problems that can arise in the devices' interactions with biological systems and the fact that the design decisions must be tested carefully. This review focuses on the main fields of application for rapid prototyping in biomedical engineering and health sciences, as well as on the most remarkable challenges and research trends.

show abstract

Rapid prototyping of scaphoid and lunate bones

Cited by 43 publications

References 33 publications

Bicomponent Microneedle Array Biosensor for Minimally‐Invasive Glutamate Monitoring

Bicomponent Microneedle Array Biosensor for Minimally‐Invasive Glutamate Monitoring

Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing

Rapid Prototyping for Biomedical Engineering: Current Capabilities and Challenges

Contact Info

Product

Resources

About