2018
DOI: 10.1002/anie.201810917
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Rapid, Quantitative, and Ultrasensitive Point‐of‐Care Testing: A Portable SERS Reader for Lateral Flow Assays in Clinical Chemistry

Abstract: The design of a portable Raman/SERS‐LFA reader with line illumination using a custom‐made fiber optic probe for rapid, quantitative, and ultrasensitive point‐of‐care testing (POCT) is presented. The pregnancy hormone human chorionic gonadotropin (hCG) is detectable in clinical samples within only 2–5 s down to approximately 1.6 mIU mL −1 . This acquisition time is several orders of magnitude shorter than those of existing approaches requiring expensive Raman instrumentation, and the meth… Show more

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Cited by 256 publications
(168 citation statements)
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“…(c) Photograph of the powerful (up to 450 mW) yet compact 785 nm diode laser. (Adapted from Tran et al (2019) [59] with permission from Wiley.) very suitable for on-site inspection because of its portability.…”
Section: Progress In Portable Raman Spectrometersmentioning
confidence: 99%
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“…(c) Photograph of the powerful (up to 450 mW) yet compact 785 nm diode laser. (Adapted from Tran et al (2019) [59] with permission from Wiley.) very suitable for on-site inspection because of its portability.…”
Section: Progress In Portable Raman Spectrometersmentioning
confidence: 99%
“…These parts directly determine the performance of a portable Raman spectrometer and the potential application of the instruments (Figure 3). [59][60][61][62] With the development of various new technologies, portable Raman spectrometers will become smaller and smaller, with higher resolution, more comprehensive performance, and lower prices.…”
Section: Progress In Portable Raman Spectrometersmentioning
confidence: 99%
“…Among many different approaches, microfluidic devices, lateral-flow assays, and lab-on-a-chip assays are the most common diagnostic assay platforms that have been developed and tested for infectious diseases [94,[115][116][117][118][119][120]. SERS-based assays have been integrated into these devices to be used for both qualitative and quantitative biomarker detection [7,8,70,73,91,94,[121][122][123][124]. Integration of SERS detection schemes into lateral flow assays are commonly seen in the recent work related to infectious disease diagnosis [91,122].…”
Section: Sers-based Diagnostic Devices and Assay Platformsmentioning
confidence: 99%
“…Among new detection modalities, surface-enhanced Raman spectroscopy (SERS) has emerged as a powerful analytical technique for molecular analysis, which can be particularly advantageous for diagnostic purposes when the Raman spectroscopy is combined with inherent optical and chemical properties of plasmonic nanoparticles [4][5][6][7][8][9][10][11][12][13]. SERS is the main method of enhancing the inherently weak Raman intensity, such that Raman scattering can be widely utilized in analytical applications.…”
Section: Introductionmentioning
confidence: 99%
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