Rapid response infrastructure for pandemic preparedness in a tertiary care hospital: lessons learned from the COVID-19 outbreak in Cologne, Germany, February to March 2020

Schommers, Philipp; Suárez, Isabelle; Köehler, Philipp; Gruell, Henning; Klein, Florian; Maurer, Christian; Langerbeins, Petra; Schmidt-Hellerau, Kirsten; Malin, Jakob J; Stecher, Melanie; Jung, Norma; Wiesmüller, Gerhard Andreas; Meißner, Anna-Katharina; Zweigner, Janine; Langebartels, Georg; Kolibay, Felix; Suárez, Víctor; Burst, Volker; Valentin, Philippe; Schedler, Dirk; Cornely, Oliver A.; Hallek, Michael; Fätkenheuer, Gerd; Rybniker, Jan; Lehmann, Clara

doi:10.2807/1560-7917.es.2020.25.21.2000531

Cited by 21 publications

(23 citation statements)

References 10 publications

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“…Nasopharyngeal and conjunctival swabs were placed each in a universal transport medium (UTM) (Copan Diagnostics, Murrieta, USA (USA)) and nucleic acids were extracted from UTM using a MagNA Pure 96 (Roche, Basel, Switzerland). SARS-CoV-2-RNA was detected by real-time RT-PCR confirming the presence of the viral E and RdRP genes (TIB molbiol, Berlin, Germany) or E and S genes (Altona Diagnostics GmbH, Hamburg, Germany), respectively, using a LightCycler 480 or LightCycler 480 II (Roche, Basel, Switzerland) [17]. SPSS version 26.0 for Mac (SPSS, Inc., Chicago, IL) was used for all statistical analyses.…”

Section: Methodsmentioning

confidence: 97%

No secret hiding place? Absence of SARS-CoV-2 on the ocular surface of 1145 hospitalized patients in a pandemic area

Rokohl

Grajewski

Matos

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Objectives The aims of this study were to evaluate the isolated prevalence of real-time reverse transcriptase-polymerase chain reaction (RT-PCR)–confirmed SARS-CoV-2 on the ocular surface without systemic infection in hospitalized asymptomatic patients and to determine the risk for ophthalmologists and medical staff to be infected by prescreened asymptomatic patients in a tertiary eye care center. Methods In this prospective, observational study, bilateral swaps of the conjunctiva in the lower fornices as well as nasopharyngeal swaps were collected in 1145 hospitalized asymptomatic patients of a tertiary eye care center. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) analysis was performed for each swap to evaluate the prevalence of SARS-CoV-2. Demographic data and potential risk factors for an isolated infection of the ocular surface were noted. Results Two thousand two hundred eighty-eight (99.9%) of all 2290 tested eyes had negative results in the RT-PCR analysis of the conjunctival swabs. One patient had bilateral false-positive results in the conjunctival swabs. None of the 1145 patients had any positive RT-PCR-confirmed result in the nasopharyngeal swabs. Conclusions The risk for an isolated conjunctival viral activity in patients with a negative nasopharyngeal swab-based RT-PCR seems to be absent or extremely low, suggesting no need to perform additional conjunctival swabs in patients with negative nasopharyngeal swabs. Furthermore, the risk of a work-related SARS-CoV-2 infection due to direct contact with preselected asymptomatic patients in an eye care center is very low, especially when additional hygiene standards and safe distances are respected carefully. This might reassure medical staff and reduce the fear of SARS-CoV-2 infection.

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Section: Methodsmentioning

confidence: 97%

No secret hiding place? Absence of SARS-CoV-2 on the ocular surface of 1145 hospitalized patients in a pandemic area

Rokohl

Grajewski

Matos

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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“…[45] Germany adopted COVID-19 rapid response infrastructure (CRRI) model to manage rapid escalation to maintain critical care services functionality. [46] COVID-care unit should have dedicated diagnostic and other support units in close proximity; one-way movement of resources and personnel; and negative pressure environment in all involved space. [13] Restructuring should ensure separate donning and doffing area for each COVID-care unit; dedicated resting and refreshment area; satellite pharmacy and supplies.…”

Section: Resourcesmentioning

confidence: 99%

Hospital Preparedness and Response Framework during infection pandemic

Thapa

2021

Preprint

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Coronavirus disease 2019 (COVID-19) has put an unprecedented burden to world health, economy and social life with possible long-term consequences. The velocity and mass of this infection pandemic had already overwhelmed every robust health care system in the world. The evidence pertaining to this novel infection pandemic is evolving, so are the challenges in terms of adequate preparedness and response. In this review, we enumerate the strategic and operational domains and build a functional framework for the management of hospital mass infection incidents due to COVID-19 and similar future pandemics. This functional framework could assist health policy maker and health care worker to implement, innovate, and translate preparedness and response to save valuable life and resources.

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“…While the CRRI shares common traits with eTCB, it is unique as it recommissioned an entirely separate building for its purpose and all patients suspected of infection were to approach CRRI directly for initial triaging with nasopharyngeal swab and other preliminary tests. 11 According to authors, the implementation of CRRI effectively reduced the burden of the hospital's ER department while increasing the numbers of tests being conducted. 11 …”

Section: Introductionmentioning

confidence: 99%

“… 11 According to authors, the implementation of CRRI effectively reduced the burden of the hospital's ER department while increasing the numbers of tests being conducted. 11 …”

Section: Introductionmentioning

confidence: 99%

Learning from the first wave: Lessons about managing patient flow and resource utilization on medical wards at providence health during the COVID-19 pandemic

et al. 2021

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We report the successful implementation of a modified Traffic Control Bundling (TCB) protocol called “Red, Yellow and Green” on the inpatient medical units at St. Paul's Hospital in Vancouver, Canada during the first wave of the coronavirus disease 2019 (COVID-19) pandemic. The modified TCB protocol demonstrates an important example on how hospitals can rapidly reorganize operational and clinical processes to reallocate existing capacity to minimize exposure, improve traffic flow and reduce nosocomial transmissions of COVID-19 to health care workers (HCWs) and other patients. Preliminary evidence demonstrates the benefits on how an existing facility can be redesigned for adjustable ward capacity to provide disease containment under a context of uncertainty of disease transmission and varying patient load. Important lessons in preparation for the evolution of the pandemic fall into categories of risk management, capacity and demand management.

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Rapid response infrastructure for pandemic preparedness in a tertiary care hospital: lessons learned from the COVID-19 outbreak in Cologne, Germany, February to March 2020

Cited by 21 publications

References 10 publications

No secret hiding place? Absence of SARS-CoV-2 on the ocular surface of 1145 hospitalized patients in a pandemic area

No secret hiding place? Absence of SARS-CoV-2 on the ocular surface of 1145 hospitalized patients in a pandemic area

Hospital Preparedness and Response Framework during infection pandemic

Learning from the first wave: Lessons about managing patient flow and resource utilization on medical wards at providence health during the COVID-19 pandemic

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