Rapid sampling of extracellular dopamine in the rat prefrontal cortex during food consumption, handling and exposure to novelty

Feenstra, Matthijs G.P.; Botterblom, M.H.A.

doi:10.1016/s0006-8993(96)00945-6

Cited by 166 publications

(95 citation statements)

References 33 publications

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“…Since novelty and drugs of abuse are thought to share similar neural substrates (Feenstra and Botterblom, 1996;Rebec et al, 1997;Beaufour et al, 2001), it is possible that repeated exposure to enriching novel stimulation during development may activate these substrates repeatedly, thus reducing the relative reinforcing strength of subsequent reinforcers. Recent neurochemical work from our laboratory suggests that this environment-induced decrease in incentive salience may involve, at least in part, a change in dopamine transporter function in the medial prefrontal cortex (Zhu et al, 2004(Zhu et al, , 2005.…”

Section: Discussionmentioning

confidence: 99%

Environmental enrichment decreases responding for visual novelty

Cain

Green

Bardo

2006

Behavioural Processes

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Previous research has demonstrated that rats reared in an enriched condition (EC) with novel objects and social partners self-administer less amphetamine compared to rats raised in an isolated condition (IC). However, it is unclear if the enrichment-induced decrease in stimulant self-administration generalizes to non-drug rewards such as those provided by novel environmental stimuli. In the current study, EC, IC, and social condition (SC) rats were raised from 21 to 51 days of age before being tested in a two-lever operant conditioning chamber in which responding on one lever (active lever) resulted in illumination of a cue light. In Experiment 1, rats were initially assessed for baseline responding (no contingency) and then the contingent light was introduced. EC rats responded less than IC rats for the contingent light stimulus; however, EC rats also displayed a lower rate of baseline responding. In Experiment 2, rats were trained initially to lever press for a sucrose reward to decrease differences in baseline responding. While sucrose pretraining decreased baseline response differences between groups, EC rats still responded less for the contingent light stimulus than IC or SC rats. These results suggest that environmental enrichment decreases the incentive value of visual novelty.

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Section: Discussionmentioning

confidence: 99%

Environmental enrichment decreases responding for visual novelty

Cain

Green

Bardo

2006

Behavioural Processes

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“…And finally, we assessed whether mPFC 5-HT2 family receptors may modulate mesocortical DA release induced by natural physiological phenomena. Since mesocortical dopamine neurons are extremely responsive to stress (Thierry et al, 1976;Abercrombie et al, 1989;Sorg and Kalivas, 1993;Feenstra and Botterblom, 1996;Inglis and Moghaddam, 1999), and stress increases 5-HT in the mPFC (eg Kawahara et al, 1993), we examined the effect of cortical administration of the 5-HT2A receptor antagonist M10097 on DA release induced physiologically by stress (20 min of gentle handling). To assess the potential involvement of other 5-HT2 receptor subtypes, these results were contrasted with those following cortical administration of the selective 5-HT2B/C inverse agonist, SB 206,553.…”

Section: Introductionmentioning

confidence: 99%

Evidence for the Preferential Involvement of 5-HT2A Serotonin Receptors in Stress- and Drug-Induced Dopamine Release in the Rat Medial Prefrontal Cortex

Pehek

Nocjar

Roth

et al. 2005

Neuropsychopharmacol

175

104

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The mechanism(s) by which serotonin modulates dopamine release in the medial prefrontal cortex is not known, although studies suggest an involvement of 5-HT2 family receptors. We employed in vivo microdialysis and putatively selective 5-HT2A antagonists (M100907, MDL 11,939, SR46349B) to determine if 5-HT2A receptors are responsible for both drug-and stress-induced DA release in the medial prefrontal cortex. MDL 11,939 and SR46349B receptor-binding studies indicated, for the first time, that only MDL 11,939 had greater selectivity for the 5-HT2A vs the 5-HT2C receptor subtypes similar to M100907, and that both showed low or no affinity for non-5-HT2 receptors. Reverse dialysis with 5-HT2A antagonists had little or no effect on basal dopamine efflux. However, intracortical administration of MDL 11,939 or M100907 attenuated dopamine release induced by systemic administration of the 5-HT2 agonist DOI. Dual-probe microdialysis demonstrated that systemic DOI also increased glutamate concentrations in the ventral tegmental area (VTA). This was blocked by intracortical M100907. Cortical perfusion with M100907, or the atypical antipsychotic drug risperidone, but not the 5-HT2B/C ligand SB 206553, also decreased dopamine release induced physiologically by stress. These results indicate that stimulation of cortical 5-HT2A receptors increases the release of dopamine from the mesocortical system. They suggest that this effect may be mediated by increases in glutamate release from corticotegmental projections to the VTA. Additionally, they indicate that cortical 5-HT2A receptors modulate evoked dopamine release, such as that observed physiologically following mild stress. These findings may have implications for the pharmacological treatment of disorders resulting from or exacerbated by stress.

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“…It is well known that exposure to non-aversive arousing stimuli or activation of cognitive processes are both capable of inducing an increase in cortical dopaminergic activity (Feenstra et al 1995;Feenstra and Botterblom 1996). In addition, a number of findings obtained from microdialysis and postmortem studies have consistently shown that mesoaccumbal and mainly mesocortical dopaminergic pathways are selectively activated by diverse types of uncontrollable aversive stimuli (Thierry et al 1976;Fadda et al 1978;Deutch et al 1985;Abercrombie et al 1989).…”

mentioning

confidence: 99%