Rapid scaling-up of antiretroviral therapy in 10 000 adults in Côte d'Ivoire: 2-year outcomes and determinants

Abstract

In this rapidly scaling-up program, survival and immune reconstitution were good; women and patients followed up in centers with longer experience had better outcomes; outcomes were similar in zidovudine/stavudine-based regimens and in efavirenz/nevirapine-based regimens. Decreasing the rate of loss to follow-up should now be the top priority in antiretroviral treatment rollout.

First Antiretroviral Therapy Changes in People Living with HIV in Senegal: Incidence, Causes and Predictive Factors

“…In Mali, the study rather focused on line-of-treatment changes and reported a second-line incidence of 3.3/100 PY [9]: a low incidence consistent with the one of our study and other data from developing countries [5,10,[16][17][18][19][20]. The mechanisms of "economy of molecules" can be put forward as an explanation but also the routine nonavailability of the viral load.…”

Baseline characteristics, response to and outcome of antiretroviral therapy among patients with HIV-1, HIV-2 and dual infection in Burkina Faso

“…12 Since the introduction of antiretroviral therapy (ART), many studies from resource-limited settings, particularly in Africa, have described the clinical characteristics, clinical response and treatment outcomes of HIV-1-infected patients on ART. [13][14][15][16][17][18][19][20] However, there is a dearth of similar published information for HIV-2 21,22 and dual HIV-1/2, probably because these infections are less prevalent and are concentrated in West Africa. Although individuals infected with HIV-2 and HIV-1/2 are a considerable minority compared with HIV-1, assessing their baseline characteristics and their response to and outcomes on ART remains important.…”

Prevention of Early Mortality by Presumptive Tuberculosis Therapy Study: An Open Label, Randomized Controlled Trial

“…4 Low body mass index (BMI < 18 kg/m 2 ) has also been associated with early mortality. [6][7][8][9][10][11][12][13] Unfortunately, only 45% of HIVinfected people know their status, which contributes to the still significant proportion (30%) with a CD4 count < 100 cells/μL at presentation despite raising the CD4 threshold for initiating treatment particularly in men. 14,15 Tuberculosis (TB) is a common cause of ART-associated death [16][17][18] among HIV-infected people in SSA, particularly in east and southern Africa.…”