Rapid screening for smokeless powders using DART-HRMS and thermal desorption DART-HRMS

Lennert, Emily; Bridge, Candice

doi:10.1016/j.forc.2019.100148

Cited by 14 publications

(6 citation statements)

References 14 publications

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“…Thermal assistance (e.g., preconcentration, desorption, etc.) has been employed with ambient MS to examine explosives and smokeless powders, , seized drugs, and emerging pollutants in drinking water. , Various substrates capable of spray-based ionization have been employed for targeted sub-sampling from complex forensic samples as a way to accommodate problematic matrices and surface geometries, such as swab touch spray ionization, wooden-tip ESI, and thread spray MS . Of note, paper-based substrates have been modified by both physical and chemical means to include preparative measures and increase analytical performance, such as the use of hydrophobic coatings to increase spray duration or analyte-specific sensitivity …”

Section: Introductionmentioning

confidence: 99%

Filter Cone Spray Ionization Coupled to a Portable MS System: Application to On-Site Forensic Evidence and Environmental Sample Analysis

Fatigante

Mukta

Lawton

et al. 2019

J. Am. Soc. Mass Spectrom.

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The complexity of field-borne sample matrices and the instrumental constraints of portable mass spectrometers (MS) often necessitate that preparative steps are added prior to ambient MS methods when operated on-site, but the corresponding decrease in throughput and experimental simplicity can make field operation impractical. To this end, we report a modified ambient MS method, filter cone spray ionization (FCSI), specifically designed for simple, yet robust, processing of bulk forensic evidence and environmental samples using a fieldable MS system. This paper-crafted source utilizes low-cost laboratory consumables to produce a conical structure that serves as a disposable, spray-based ionization source. Integrated extraction and filtration capabilities mitigate sample heterogeneity and carryover concerns and expedite sample processing, as characterized through the analysis of a variety of authentic forensic evidence types (e.g., abused pharma tablets, counterfeit/adulterated tablets, crystal-based drugs, synthetic marijuana, toxicological specimens) and contaminated soil samples. The data presented herein suggests that the FCSI-MS design could prove robust to the rigors of field-borne, bulk sample screening, overcoming the inefficiencies of other ambient MS methods for these sample classes. Novel applications of FCSI-MS are also examined, such as the coupling to trace evidence vacuum filtration media.

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Section: Introductionmentioning

confidence: 99%

Filter Cone Spray Ionization Coupled to a Portable MS System: Application to On-Site Forensic Evidence and Environmental Sample Analysis

Fatigante

Mukta

Lawton

et al. 2019

J. Am. Soc. Mass Spectrom.

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“…Therefore, several follow-up studies will be centered on these preparation methods and alternative congurations. [35][36][37][38][39] Additionally, statistical evaluations involving algorithms to extract relevant OGSR proles and relate information to potential ammunition sources are of interest. This study serves as initial proof of the feasibility and versatility of DART-MS in monitoring OGSR signatures from various substrates quickly and effectively.…”

Section: Discussionmentioning

confidence: 99%

“…This study serves as initial proof of the feasibility and versatility of DART-MS in monitoring OGSR signatures from various substrates quickly and effectively. [36][37][38][39] Disclaimer Certain commercial products are identied in order to adequately specify the procedure; this does not imply endorsement or recommendation by NIST, nor does it imply that such products are necessarily the best available for the purpose.…”

Section: Discussionmentioning

confidence: 99%

A feasibility study of direct analysis in real time-mass spectrometry for screening organic gunshot residues from various substrates

Ledergerber,

Feeney,

Arroyo

et al. 2023

Anal. Methods

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“…The gas flow is directed at a sample surface, placed within the source in open air; analyte ions are formed in a chemical ionisation-like process and desorbed whereupon they are drawn into the mass spectrometer inlet. 2 Application areas range from forensics 3 and food 4 to quality control 5 and hundreds of papers have been published using DART-MS. A good overview of the fundamentals and broad scope of the technique has been given by Gross. 6 We have reported previously that the measured temperature of the sample reaches only a fraction of the set temperature of the gas 7 and to address this problem we have developed a novel combined hot-stage microscopy-DART-MS system (HDM) which uses a miniaturised ceramic hot-stage in the ion source to give much more precise temperature control of samples than that obtained with the DART alone, as well as allowing visualisation of melting and desorption behaviour through the integrated microscope.…”

Section: Introductionmentioning

confidence: 99%

“…Application areas range from forensics 3 and food 4 to quality control 5 and hundreds of papers have been published reporting the use of DART‐MS. A good overview of the fundamentals and broad scope of the technique has been given by Gross 6 …”

Section: Introductionmentioning

confidence: 99%

Application of hot‐stage microscopy direct analysis in real time mass spectrometry (HDM) to the analysis of polymers

Ashton

Harding

Parkes

et al. 2019

Rapid Comm Mass Spectrometry

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Rationale. Polymers are ubiquitous and characterisation of their chemical, thermal and mechanical properties is important in many applications. HDM is a new technique which combines optical measurements with the benefits of ambient ionisation mass spectrometry. Physical and chemical information can be obtained as a function of sample temperature, in real-time. Methods. Samples were placed on a miniaturised hot-stage between a custom-made DART source and the ion trap mass spectrometer inlet, and subjected to both linear and cycled temperature programmes. Optical images were collected using a digital microscope and mass spectra (positive and negative ion) were recorded simultaneously. Results. Mass spectra and optical images were used to monitor the thermal expansion and release of volatile oligomers from both medical and domestic grades of silicone. Series of ions separated by 74 m/z were observed, consistent with the SiOMe2 monomer; the median mass of these increased with increasing temperature up to the decomposition point (340-400 ºC). The abundance of volatile material produced decreased with repeated thermal cycling. The coefficients of thermal expansion were calculated from optical data and were in agreement with conventional measurements (2.7-3.6 x 10-4 ºC-1). Two samples of beach sand analysed for the presence of microplastics were found to contain polyethylene and polystyrene, respectively. Conclusions. Results indicate that the novel technique of HDM can be successfully applied to the characterisation of a wide range of polymers including those in complex matrices.

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Rapid screening for smokeless powders using DART-HRMS and thermal desorption DART-HRMS

Cited by 14 publications

References 14 publications

Filter Cone Spray Ionization Coupled to a Portable MS System: Application to On-Site Forensic Evidence and Environmental Sample Analysis

Filter Cone Spray Ionization Coupled to a Portable MS System: Application to On-Site Forensic Evidence and Environmental Sample Analysis

A feasibility study of direct analysis in real time-mass spectrometry for screening organic gunshot residues from various substrates

Application of hot‐stage microscopy direct analysis in real time mass spectrometry (HDM) to the analysis of polymers

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