“…The amounts chosen were the averages found in commercial preparations (20). The sensitivity of the method is such that single-tablet analysis, even at the lowest dosage, is feasible; this sensitivity is an improvement over the diazotized 4-amino-6-chloro-m -benzenedisulfonamide method (14). Another advantage is the applicability of the method to progestin-estrogen combinations, which is an improvement over the fluorometric method (15).…”
“…The amounts chosen were the averages found in commercial preparations (20). The sensitivity of the method is such that single-tablet analysis, even at the lowest dosage, is feasible; this sensitivity is an improvement over the diazotized 4-amino-6-chloro-m -benzenedisulfonamide method (14). Another advantage is the applicability of the method to progestin-estrogen combinations, which is an improvement over the fluorometric method (15).…”
“…Several chemical methods for the estrone are found in the literature (1)(2)(3)(4)(5). However, due to the small amount of the steroid and the interference from the other ingredients in these pharmaceutical preparations, the results obtained with some of these methods were unreliable.…”
Section: Pramod P Karkhanis and Jon R Anfinsenmentioning
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