Rapid Synthesis of Gold Nanoparticles from Quercus incana and Their Antimicrobial Potential against Human Pathogens

Sarwar, Rizwana; Farooq, Umar; Shah, Muhammad Raza; Khan, Sara; Riaz, Nadia; Naz, Sadia; Ibrar, Aliya; Khan, Ajmal

doi:10.3390/app7010029

Cited by 12 publications

(6 citation statements)

References 42 publications

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“…Herein we investigate assembly of gold NPs synthesized via a green chemistry approach on PEG grafted substrates prepared by all water-based processing. We used the extract of Quercus pubescens as a reducing and stabilizing agent in the synthesis of gold NPs. , The synthesis of the gold NPs was performed by varying concentrations of the gold precursor (HAuCl 4 ), amounts of the extract and reaction times. When 1 mM gold precursor was used, the synthesis led to a mixture of prisms and spherical particles as confirmed with TEM images (see Figure S4).…”

Section: Resultsmentioning

confidence: 99%

Eco-Friendly Fabrication of Plasmonically Active Substrates Based on End-Grafted Poly(ethylene glycol) Layers

Ocal

Pekdemir

Serhatlıoğlu

et al. 2019

ACS Sustainable Chem. Eng.

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We report completely sustainable processes and materials for inexpensive and scalable fabrication of plasmonically active solid substrates, which are critical for emerging applications in sensing, catalysis, and metasurfaces. Our approach involves grafting of poly(ethylene glycol) (PEG) onto silicon oxide terminated solid substrates using all-water based processing leading to an ultrathin (12 nm) and smooth (roughness of ∼1 nm) functional layer. The resulting surfaces facilitate robust and effective immobilization of gold nanoparticles (NPs) with a density that is superior to the organic solvent based processing. This new process achieves size dependent assembly of the citrate-stabilized gold NPs resulting in high plasmonic activity in surface-enhanced Raman scattering (SERS). The use of leaf extracts derived from Quercus pubescens as a reducing and stabilizing agent allowed for green synthesis of gold NPs with an average diameter of 25.6 ± 11.1 nm. The assembly of the green synthesized gold NPs on all-water processed PEG grafted layers enabled a fully sustainable route for fabrication of plasmonically active solid substrates. The resulting substrates exhibited high SERS response over the entire (∼1 cm 2 ) substrate surface with an analytical enhancement factor of 9.48 × 10 4 for the probe molecule rhodamine 6G under 532 nm laser excitation. A microfluidic device was also constructed on the fabricated platform for SERS mediated simultaneous detection of two nonsteroidal anti-inflammatory drugs, dexketoprofen and ibuprofen, which are widely used in human medicine and present as contaminants in wastewater. The biocompatibility of PEG together with all-water based processing overcome the need for waste management and ventilation of the working place enabling cost and energy efficient, environmentally benign fabrication of plasmonic devices.

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Section: Resultsmentioning

confidence: 99%

Eco-Friendly Fabrication of Plasmonically Active Substrates Based on End-Grafted Poly(ethylene glycol) Layers

Ocal

Pekdemir

Serhatlıoğlu

et al. 2019

ACS Sustainable Chem. Eng.

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“…Accordingly in the spectrum, the band at 3279 cm À 1 was attributed to the OÀ H symmetric stretching that came from the reduction of Au 3 + to Au 0 . Also, while the band at 1040 cm À 1 was ascribed to the aromatic CÀ C, the bands at 2919 cm À 1 and 2848 cm À 1 came from CÀ H stretching of AuNP [47][48][49]. Besides, the absorption bands at 1646 cm À 1 and 1530 cm À 1 were assigned to C=O stretching of amide-I and CÀ N stretching together with NÀ H bending of amide-II, respectively which belonged to the secondary structure of HSA in the HSAÀ AuNP composite [50,51].…”

Section: Characterization Studies Of Noble Hsaà Aunpmentioning

confidence: 96%

Human Serum Albumin−Gold Nanoparticle Based Impedimetric Sensor for Sensitive Detection of miRNA‐200c

et al. 2020

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Here, human serum albumin conjugated gold nanoparticles (HSA−AuNPs) were synthesized by a simple route to develop an impedimetric sensor for miRNA‐200c detection based on a selective oligo‐hybridization process without any labeling. The synthetic DNA capture probe for miRNA‐200c was decorated onto the HSA−AuNPs modified pencil graphite electrodes. Impedimetric signals were monitored after the hybridization process between the DNA probe and target miRNA‐200c. HSA−AuNPs adsorption time, incubation time of the capture probe and hybridization time‐temperature were optimized. The proposed miRNA‐200c biosensor demonstrated proper sensitivity and selectivity, low detection limit (1.13 fM), good reproducibility and simple direct detection of miRNA‐200c in serum.

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“…Moreover, while killing bacteria, AuNPs yield ROS. ese free radicals can destroy DNA and other metabolic components [30].…”

Section: Antibacterial Testingmentioning

confidence: 99%

Evaluation of New Film Based on Chitosan/Gold Nanocomposites on Antibacterial Property and Wound‐Healing Efficacy

Wang

et al. 2020

Advances in Materials Science and Engineering

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Chitosan (CS) is a natural polymer with applications in wound restorations and coatings for artificial implants. However, the lack of antimicrobial activity restricts its further application. Thus, the purpose of this study is to prepare CS/AuNPs film by adding gold nanoparticles (AuNPs) to modify chitosan. Through transmission electron microscopy, we found that the presence of CS can effectively prevent the agglomeration of nanoparticles. Furthermore, through the CCK experiment, we found that AuNPs at a certain concentration can improve the adhesion and proliferation of cells, which has also been proved in animal experiments, including gross appearance, histological observations, and immunofluorescence staining. Such findings support the feasibility of using the film as a promising candidate for tissue engineering of skin in a near future.

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Rapid Synthesis of Gold Nanoparticles from Quercus incana and Their Antimicrobial Potential against Human Pathogens

Cited by 12 publications

References 42 publications

Eco-Friendly Fabrication of Plasmonically Active Substrates Based on End-Grafted Poly(ethylene glycol) Layers

Eco-Friendly Fabrication of Plasmonically Active Substrates Based on End-Grafted Poly(ethylene glycol) Layers

Human Serum Albumin−Gold Nanoparticle Based Impedimetric Sensor for Sensitive Detection of miRNA‐200c

Evaluation of New Film Based on Chitosan/Gold Nanocomposites on Antibacterial Property and Wound‐Healing Efficacy

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