Rapid thawing of fresh‐frozen plasma with radio wave‐based thawing technology and effects on coagulation factors during prolonged storage at 4°C

Abstract

The new radio wave technology for thawing of FFP has a significant reduction of thawing time. The impact of thawing and storage on FV, FVIII, protein S does not significantly differ between HAT and RTD.

Clotting factor activity in fresh frozen plasma after thawing with a new radio wave thawing device

“…In summary, the occurrence of general or localized overheating by radio waves in the UFT100 environment seems to be unlikely, as we measured normal activities of temperature sensitive clotting factors after thawing. Our results support those of the study examining the prototype, which presented data on the impact of radio wave thawing of FFP on factors V and VIII and protein S, and found that those clotting factors and inhibitors remained stable …”

“…Our results support those of the study examining the prototype, which presented data on the impact of radio wave thawing of FFP on factors V and VIII and protein S, and found that those clotting factors and inhibitors remained stable. 23 Remarkably, activities of factor XI showed a statistically significant increase after 48-hour storage at 4 C (p ≤ 0.001). Yazer et al 19 reported a similar effect on factors XI and XII during storage of plasma.…”

Resuscitative goals and new strategies in severe trauma patient resuscitation

“…1 As an example, in military scenarios, routine plasma thawing is carried out on a daily basis, or methods are adopted to ensure prompt availability of FFP (universal donor plasma, rapid thawing units, specific plasma formulations), in order to optimize the management of these patients and try to reach appropriate transfusion ratios. 2,3,47 In this respect, different scores have attempted to predict patients with massive bleeding upon arrival in hospital, based on the use of clinical variables and basic explorations. A recent study comparing some of these scales has shown the Trauma Associated Severe Hemorrhage Score (TASH) to offer the best correlation, making it possible to identify those patients who do not require activation of the MTP.…”

Treatment of massive bleeding with prothrombin complex concentrate: argument against

“…The Belgian and French armies, as well as the Australian Red Cross, already use this option [28]. The use of radio wave‐based thawing technology allows thawing of frozen plasma in 8 min, with recovery of > 90% for FV and FVIII levels when compared with those before freezing [29]. …”

“…The use of radio wave‐based thawing technology allows thawing of frozen plasma in 8 min, with recovery of > 90% for FV and FVIII levels when compared with those before freezing [29].…”