Rápida cicatrización de la úlcera venosa con técnica TAPIRS-LF con láser, espuma y vendajes multicapa

Nieves, Encarnación Gimeno; Montealegre, C.

doi:10.1016/j.angio.2018.06.002

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…98 By inhibiting digestion of extracellular matrix components, thiorphan may play a protective role in lung and gut leak promoting neutrophil infiltration and microbiome translocation, respectively, following ischemic/hemorrhagic injury and reperfusion. 99,100 Finally, by inhibiting enkephalinases, thiorphan has a strong analgesic activity by disrupting nociceptive signaling. 101 Of note, endogenous opioids mediate analgesia to immobilization in vertebrate animals and inhibition of enkephalinases by thiorphan is a positive regulator of analgesic responses.…”

Section: Discussionmentioning

confidence: 99%

Red Blood Cell Metabolic Responses to Torpor and Arousal in the Hibernator Arctic Ground Squirrel

et al. 2019

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Arctic ground squirrels provide a unique model to investigate metabolic responses to hibernation in mammals. During winter months these rodents are exposed to severe hypothermia, prolonged fasting, and hypoxemia. In the light of their role in oxygen transport/off-loading and owing to the absence of nuclei and organelles (and thus de novo protein synthesis capacity), mature red blood cells have evolved metabolic programs to counteract physiological or pathological hypoxemia. However, red blood cell metabolism in hibernation has not yet been investigated. Here we employed targeted and untargeted metabolomics approaches to investigate erythrocyte metabolism during entrance to torpor to arousal, with a high resolution of the intermediate time points. We report that torpor and arousal promote metabolism through glycolysis and pentose phosphate pathway, respectively, consistent with previous models of oxygen-dependent metabolic modulation in mature erythrocytes. Erythrocytes from hibernating squirrels showed up to 100-fold lower levels of biomarkers of reperfusion injury, such as the pro-inflammatory dicarboxylate succinate. Altered tryptophan metabolism during torpor was here correlated to the accumulation of potentially neurotoxic catabolites kynurenine, quinolinate, and picolinate. Arousal was accompanied by alterations of sulfur metabolism, including sudden spikes in a metabolite putatively identified as thiorphan (level 1 confidence)-a potent inhibitor of several metalloproteases that play a crucial *

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Section: Discussionmentioning

confidence: 99%