Rapidly increasing prescribing of proton pump inhibitors in primary care despite interventions: A nationwide observational study

Abstract

Conclusion:Use of PPIs has increased substantially during the past decade, without a change in indications for use of PPIs in the same time range. Interventions to enhance adherence to guidelines and promote rational use of PPIs do not seem to have had a substantial infl uence on the overall prescribing rate.

Use of proton-pump inhibitors among adults: a Danish nationwide drug utilization study

“…Most of the studies date several years back, have clustered PPI use with use of histamine type-2 receptor antagonists (H2RA) and were not carried out in a nationwide setting. Furthermore, the studies applied different definitions of long-term use, based on either duration of therapy or used defined daily doses (DDDs) per year, without taking both parameters into account [Hungin et al 1999;Jacobson et al 2003;van Soest et al 2006;Reimer and Bytzer, 2009;Lødrup et al 2014;Haastrup et al 2014]. …”

Clinical importance of nonsteroidal anti-inflammatory drug enteropathy: the relevance of tumor necrosis factor as a promising target

“…Thus, NSAIDs and PPIs, as expected, are among the most frequently prescribed and used medications worldwide [143,144]. Although, PPIs reduce the NSAID-related upper GI adverse events, they do not protect from lesions beyond the gastroduodenal region [9].…”

Proton pump inhibitors and osteoporosis

“…Globally, the use of proton pump inhibitors is extremely widespread, and many patients are treated for prolonged periods [1]. In accordance with being one of the most widely prescribed drugs worldwide, there is a growing concern that this treatment is overprescribed and that this may have individual and societal consequences [2].…”