Rapidly Progressive Dementia in the Outpatient Clinic: More Than Prions

Day, Gregory S.; Musiek, Erik S.; Morris, John C.

doi:10.1097/wad.0000000000000276

Cited by 16 publications

(30 citation statements)

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“…77 Other common non-prion diagnoses include psychiatric illness, vascular dementia, autoimmune encephalitis, and LBD. 75,77,78,[80][81][82] Extensive differential diagnoses of RPD have been previously published 75,76,83,84 and are beyond the scope of this article. ►Table 1 lists clinical features supportive of specific etiological categories (e.g., prion, neurodegenerative, autoimmune).…”

Section: Approach To Rapidly Progressive Dementiamentioning

confidence: 99%

A Neurologist's Practical Approach to Cognitive Impairment

2021

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The global prevalence of dementia is expected to triple by the year 2050. This impending health care crisis has led to new heights of public awareness and general concern regarding cognitive impairment. Subsequently, clinicians are seeing more and more people presenting with cognitive concerns. It is important that clinicians meet these concerns with a strategy promoting accurate diagnoses. We have diagramed and described a practical approach to cognitive impairment. Through an algorithmic approach, we determine the presence and severity of cognitive impairment, systematically evaluate domains of function, and use this information to determine the next steps in evaluation. We also discuss how to proceed when cognitive impairment is associated with motor abnormalities or rapid progression.

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Section: Approach To Rapidly Progressive Dementiamentioning

confidence: 99%

A Neurologist's Practical Approach to Cognitive Impairment

2021

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“…Среди них женщин оказалось 63%, средний возраст 68 лет (от 45,4 до 89,6), уровень образования 12 лет (от 6 до 14), атипичные проявления отмечены в 90% случаев с быстрым прогрессированием. Более старший возраст был предиктором амнестической деменции при БА, симптомы паркинсонизма или зрительные корковые дисфункции определяли клиническую картину других нейродегенеративных заболеваний с быстрым прогрессированием, включая спорадическую БКЯ [51].…”

Section: нозологические различия в скорости прогрессирования деменцииunclassified

Old Age Dementia: Clinical Patterns of Progression. Part 1

Mikhailova¹

2020

Psychiatry

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Background: the clinical experience testifies to the fact, that the increase of dementia severity in late age occurs quickly in some cases and in others it proceeds slowly, which is reflected in the total duration of the disease and survival. One of the aspects of dementias research is the study of significant differences in dementia progression rates.The objective of the review was to generalize the obtained data on progression rates of late age dementias of various genesis, first of all due to Alzheimer’s disease and its associated disorders.Material and methods: papers in MedLine/PubMed bases from1990 to 2020 were selected and analyzed according to the key words: “old age”, “dementia”, “Alzheimer’s disease”, “vascular dementia”, “progression”, “progression rate”, “disease trajectories”, as well as relevant papers in the references of the analyzed works.Conclusion: the history of research of old age dementias natural course was presented in the review of scientific publications. According to the results of development of progression rates detection methods, singling out of dementias with rapid and slow increase in the severity of cognitive decline was substantiated. Works devoted to the study of frequency and nosological belonging of dementias with different progression rates were considered. In the most recent studies prognostic models with detection of various trajectories of the course of the disease were developed. The concept of various dementias progression rates admittedly has practical meaning for provision of diagnostic and treatment assistance and planning of medical and social support measures for patients with dementia and their families. Differentiation of dementia progression clinical patterns during formation of comparable groups of patients seems appropriate for investigation of new therapy methods, as well as in clinical-biological studies of pathogenesis.

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“…В другом исследовании у 67 (70%) пациентов клиники памяти скорость прогрессирования деменции оказалась больше ожидаемой за 2 года после появления симптомов. Среди них женщин оказалось 63%, средний возраст составил 68 лет (от 45,4 до 89,6 года), уровень образования в среднем 12 лет [17].…”

Section: гендерные различия возраст начала заболевания и уровень обрunclassified

“…В одном из исследований раннее появление галлюцинаций, психоза и экстрапирамидных расстройств оказалось характерным для БА с быстрым прогрессированием деменции [17]. В работе других авторов 236 больных очень мягкой и мягкой БА обследовали катамнестически в течение 5 лет с использованием нейропсихиатрического опросника для определения прогностической значимости исходных нейропсихиатрических симптомов в отношении прогрессирования деменции.…”

Section: некогнитивные (поведенческие и психопатологические) симптомыunclassified

“…В то время как в публикациях обычно больше сообщений о госпитальных случаях быстрого прогрессирования деменции, недавнее исследование касается [17].…”

Section: некогнитивные (поведенческие и психопатологические) симптомыunclassified

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Old Age Dementias: Factors Associated with Dementia Progression Rate. Part 2

Mikhailova¹

2020

Psychiatry

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Background: steady progression of dementia is characterized with various rates, which specified clinical differentiation of dementias with rapid and slow increase of cognitive decline severity. The search for clinical factors, hypothetically responsible for differences in late age dementia progression rate, is one of the aspects of investigation of late age dementias.The objective was to generalize the results of the study of separate clinical factors effect on the differences in the late age dementia progression rate.Material and methods: papers in MEDLINE/PubMed bases from 1990 to 2020 were selected and analyzed according to the key words: “late age”, “dementia”, “progression rate”, “age of onset”, “non-cognitive disorders”, “nosomodifying therapy”, as well as relevant papers in the literature of the analyzed works.Conclusion: various parameters of the disease were studied as associated with dementia progression pattern. As regards part of them the results achieved compliance in recognition of association with dementia progression rate. As for the others this evidence is ambiguous. There are large discrepancies in attitudes to gender differences, while early age of disease onset, initially great intensity of neuropsychiatric disorders are concordantly admitted as associated with dementia rapid progression. The researchers are united with steady idea of nonlinear character of dementia progression at the stages of mild, moderate and severe dementia.The results of study of comorbidity are basically similar with regard to recognition of SFD influence, first of all, of arterial hypertension on dementia progression rate. The evidence of the efficacy of nosomodifying therapy, decelerating dementia progression, is unanimously considered an urgent problem. The development of new dementia pathogenesis concepts and the search for new therapy targets, are conducive to the solution of this problem. The results of the investigated direction of studies confirm the hypothesis of the fact that dementia progression occurs according to various pathogenetic mechanisms, which determine the dementia increasing rate. The management of patients with dementia in practice presupposes taking into account of various factors, influencing dementia progression rate, for planning of the volume and character of medical care.

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Rapidly Progressive Dementia in the Outpatient Clinic: More Than Prions

Cited by 16 publications

References 50 publications

A Neurologist's Practical Approach to Cognitive Impairment

A Neurologist's Practical Approach to Cognitive Impairment

Old Age Dementia: Clinical Patterns of Progression. Part 1

Old Age Dementias: Factors Associated with Dementia Progression Rate. Part 2

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