2024
DOI: 10.1098/rstb.2023.0234
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Rapidly reversible persistent long-term potentiation inhibition by patient-derived brain tau and amyloid ß proteins

Tomas Ondrejcak,
Igor Klyubin,
Neng-Wei Hu
et al.

Abstract: How the two pathognomonic proteins of Alzheimer’s disease (AD); amyloid ß (Aß) and tau, cause synaptic failure remains enigmatic. Certain synthetic and recombinant forms of these proteins are known to act concurrently to acutely inhibit long-term potentiation (LTP). Here, we examined the effect of early amyloidosis on the acute disruptive action of synaptotoxic tau prepared from recombinant protein and tau in patient-derived aqueous brain extracts. We also explored the persistence of the inhibition of LTP by d… Show more

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