Rare case of adult pancreatic haemangioma and literature review

Raymundo, Selma Regina de Oliveira; Hussain, Kassim Mohamede Kassim; Hussein, Kassim Guzzon; Kuga, Magali Lúcia

doi:10.1136/bcr-2018-226456

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…Thus, it is necessary to undertake both CT and MRI for a more reliable diagnosis. However, it is still difficult to make a definite diagnosis in some cases (11,17,21,22,27) though both CT and MRI were undertaken. Endoscopicultrasound guided fine needle aspiration (EUS-FNAB) was undertaken in 3 reports (13,18,22), which can give some hints and exclude the malignancy of the lesion.…”

Section: Discussionmentioning

confidence: 99%

Rare adult pancreatic hemangioma: review of the literature with a case report

Jun

Chen

2020

Gland Surg

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Adult pancreatic hemangioma is an especially rare benign tumor that is hard to diagnose through imaging examinations, meanwhile its histopathological and immunohistochemical studies have rarely been reported. At this time, only 29 cases in 27 publications have been reported. We report a new case as well as review these literatures. A 71-year-old woman came to our hospital with slight pain on left upper abdomen for three days. But the results obtained from the physical or laboratory examination were all negative so that her symptoms could not be explained clearly. The imaging examinations including ultrasonography and computed tomography both showed a mixed mass in the neck of the pancreas. The preoperative diagnosis of cystadenoma or adenocarcinoma was made, with high suspicious of malignancy. The patient underwent a central pancreatectomy with pancreatojejunostomy, but the pathologic diagnosis was pancreatic hemangioma. The immunohistochemical examination found the positive benign vascular markers (CD31, CD34) and negative lymphocyte markers (D2-40). Moreover, Ki-67 negativity also revealed its benign nature. After 36 months of follow-up, the patient has no complaints for abdominal pain. In conclusion, adult pancreatic hemangioma is extremely rare without any specific clinical manifestations. It is usually diagnosed postoperatively by histological examination and immunohistochemical studies. Imaging examinations, including computed tomography and magnetic resonance imaging, can't give definite conclusion. Endoscopicultrasound guided fine needle aspiration is conditionally worth doing, which can give some hints and exclude the malignancy of the lesion. If malignancy can be safely ruled out, the surgical decision must be made according to risk-benefit analysist. Maybe close observation and regular follow-up are more beneficial options.

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Section: Discussionmentioning

confidence: 99%

Rare adult pancreatic hemangioma: review of the literature with a case report

Jun

Chen

2020

Gland Surg

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Conservative management of adult pancreatic haemangioma: case study and literature review

et al. 2021

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Pancreatic haemangiomas are a rare cause of pancreatic lesions in adults. Diagnosis is challenging as they are seldom suspected and difficult to differentiate on imaging. Historically, pancreatic haemangiomas have been managed surgically despite their benign nature, largely due to diagnostic uncertainty. We present the case of a 69-year-old woman who, through combination of radiological, biochemical and endoscopic investigations, was diagnosed with pancreatic haemangioma and managed conservatively, avoiding the morbidity and mortality associated with surgical resection of a benign lesion.

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Pancreatic cavernous hemangioma complicated with chronic intracapsular spontaneous hemorrhage: A case report and review of literature

T¹

2023

World J Clin Cases

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Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths. The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism, including mitochondrial stress response. Mitokines, soluble proteins produced and secreted in response to mitochondrial stress, play an essential immunomodulatory role. Immunotherapy has emerged as a crucial treatment option for HCC. However, a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment. Therefore, exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy. This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function. In addition, a systematic review of mitokines-mediated immunomodulation in HCC is presented. Finally, the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized. Recent progress in mitokine research represents a new prospect for mitochondrial therapy. Considering the potential of mitokines to regulate immune function, investigating them as a relevant molecular target holds great promise for the diagnosis and treatment of HCC.

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Rare case of adult pancreatic haemangioma and literature review

Cited by 4 publications

References 24 publications

Rare adult pancreatic hemangioma: review of the literature with a case report

Rare adult pancreatic hemangioma: review of the literature with a case report

Conservative management of adult pancreatic haemangioma: case study and literature review

Pancreatic cavernous hemangioma complicated with chronic intracapsular spontaneous hemorrhage: A case report and review of literature

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