Rare Case of Atypical Epitelioid Hemangioma of Penis Initially Misdiagnosed as Peyronie's Disease: Report With Clinical, Radiologic, and Immunohistochemical Analysis

Natali, Alessandro; Nesi, Gabriella; Vittori, Gianni; Minervini, Andrea; Franchi, Alessandro; Agostini, S.; Carini, Marco; Menghetti, I.

doi:10.1016/j.urology.2008.01.035

Cited by 10 publications

(19 citation statements)

References 11 publications

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“…In prior case reports, this tumour has most commonly presented as a solitary painful nodule on the dorsum of the shaft of the penis, occasionally with induration or multiple lesions. 1,[5][6][7][8][9] There is one previous case of associated painful erections, and a second with reported dyspareunia; however, these were associated with a palpable lesion. 5,8 Ours is the first reported case of an epithelioid hemangioma that was neither visible nor palpable on the penis that required imaging to discover.…”

Section: Discussionmentioning

confidence: 99%

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Painful erections secondary to rare epithelioid hemangioma of the penis

Barber

Domes

2014

CUAJ

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Epithelioid hemangioma is a rare benign vascular tumour that atypically involves the penis and usually presents as a painful nodule. A 35-year-old man presented with a 5-month history of painful erections without a clinically apparent lesion or deformity. Magnetic resonance imaging (MRI) with pharmacologically induced erection demonstrated a 1.3-cm nodular lesion deep to the skin at the base of his penis. Following local excision of the lesion, which was diagnosed as an epithelioid hemangioma, the patient was symptom free. This case demonstrates a rare etiology of painful erections with a unique presentation. To the authors' knowledge, it is also the first report of MRI with intracavernosal injection of trimix to assess for a specific cause of painful erections.

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Section: Discussionmentioning

confidence: 99%

“…4 Involvement of the penis is rare, with fewer than 30 reported cases in the English literature. 6 Of these cases, there is a tendency for the lesion to present as a clinically evident painful nodule on the dorsal aspect of the shaft of the penis. …”

Section: Introductionmentioning

confidence: 99%

Painful erections secondary to rare epithelioid hemangioma of the penis

Barber

Domes

2014

CUAJ

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“…The exuberant (atypical) form contains aggregates of epithelioid endothelial cells with an indeterminate growth pattern and immature vessels [2]. On immunohistochemical staining, epithelioid hemangiomas are positive for CD31, CD34 and factor VIII-related antigen and negative for keratin and epithelial membrane antigens [6]. …”

Section: Discussionmentioning

confidence: 99%

“…Clinical examination usually reveals a solitary, painful, well circumscribed nodule on the dorsum of the penile shaft with no lymphadenopathy or penile deformity. Clinical investigations include full blood count to exclude eosinophilia, ultrasound scan, color Doppler and MRI scans of the penis and the pelvis if indicated [6]. Treatment is surgical and comprises complete local excision of the tumor with a rim of normal tissue.…”

Section: Discussionmentioning

confidence: 99%

Epithelioid hemangioma of the penis: case report and review of literature

et al. 2011

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IntroductionEpithelioid hemangioma is a rare vascular tumor found in the penis. It is essential to avoid misdiagnosis with Peyronie's disease and penile cancer, as management differs significantly.Case presentationWe present a case of epithelioid hemangioma of the penis in a 50-year-old Caucasian man. We also review the literature to evaluate the incidence of benign vascular anomalies of the penis and their management.ConclusionsEpithelioid hemangioma of the penis should be considered in the differential diagnosis of patients presenting with painful penile lumps. A thorough histological and immunohistochemical examination is required to make the diagnosis. Optimal management is complete local excision and periodic physical examination for local recurrence.

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“…Epithelioid hemangioma, also known as angiolymphoid hyperplasia with eosinophilia, represents a rare vascular proliferation with a predilection for the ear, forehead and scalp . Occurrence on the penis is rare and all but two reported cases have been solitary or 2 closely grouped nodules treated with surgical excision . Histopathologically, it may be misdiagnosed as an epithelioid hemangioendothelioma, epithelioid angiosarcoma, cutaneous epithelioid angiomatous nodule (CEAN), or Kaposi sarcoma …”

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confidence: 99%