Rare case of nasal cavity chondrosarcoma presenting only with unilateral decreased vision

Abstract

Chondrosarcomas comprise a heterogeneous group of malignant lesions characterized by production of cartilage matrix. Sinonasal involvement is extremely rare, with nasal congestion and obstruction being the leading symptoms. We present a rare case of large chondrosarcoma of the nasal cavity and paranasal sinuses, primarily presenting with ocular symptoms.

Sinonasal Chondrosarcoma With Unusual Orbital Invasion

“…Of these, few were sinonasal in origin. [3][4][5][6][7][8][9][10][11][12][13][14] The most common presenting symptoms reported were proptosis, (n = 7, 50%) and painless loss of vision (n = 6, 43%). 3,[6][7][8][11][12][13][14] Facial swelling was described by 2 patients, and eye pain and diplopia by 1 patient each.…”

“…3–14 The most common presenting symptoms reported were proptosis, (n = 7, 50%) and painless loss of vision (n = 6, 43%). 3,6–8,11–14 Facial swelling was described by 2 patients, and eye pain and diplopia by 1 patient each. 6,10,12,14 The most common site of origin was the ethmoid sinus, of which 6 cases (43%) of chondrosarcoma with orbital invasion have been reported.…”

“…5,7–9,11 Three cases originated within the nasal cavity. 12–14 Histologically, the conventional subtype was the most prevalent, diagnosed in 9 cases (64%). 3,6,7,11 Two cases were mesenchymal chondrosarcoma (14%), and the dedifferentiated subtype accounted for 1 case (7%).…”

“…4,9 Seven cases (50%) invaded the orbit via the medial wall. 3,4,6,8,9,12,13 The orbital apex was involved in 4 cases (29%), and was associated with compressive optic neuropathy in 3 of these. 5,7,11 Five cases (36%) demonstrated orbital invasion via the orbital floor.…”