Rare case of pancreatic adenocarcinoma with spermatic cord and testicular metastasis

Abstract

Male gonadal metastases from pancreatic carcinomas are extremely rare, with fewer than 20 cases documented in the literature. Herein, we report a man in his 50s who presented at the genitourinary outpatient department with an enlarged scrotum (right side) that had developed progressively over several weeks. He also reported mild upper abdominal discomfort. Scrotal sonography revealed a hydrocele on the right side without testicular lesions. A mass pancreatic tail lesion with invasion of the spleen and left adrenal gland was identified through abdominal CT and MRI. Endoscopic ultrasound fine needle biopsy and right radical orchiectomy were performed. Moderately differentiated adenocarcinoma of the pancreatic tail with hematogenous metastasis to the right testis, epididymis and spermatic cord was verified on the basis of the pathology report. Disease progression occurred despite the patient receiving palliative chemoradiation therapy.

Spermatic cord tumors — review of the literature

“…The primary tumor usually occurs in the gastrointestinal tract [73]. Metastases to the spermatic cord of tumors such as renal adenocarcinoma [1] and pancreatic adenocarcinoma [74,75] have also been described in the literature. Treatment includes inguinal orchidectomy with high spermatic cord resection and postoperative chemoradiotherapy [75].…”