Rare Earth Doped Apatite Nanomaterials for Biological Application

Perera, Thalagalage Shalika Harshani; Han, Yingchao; Lü, Xiaofei; Wang, Xinyu; Dai, Hanren; Li, Shipu

doi:10.1155/2015/705390

Cited by 36 publications

(23 citation statements)

References 56 publications

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“…The emission peak position and the emission intensity of the Eu 3+ transitions lines depend on the local symmetry in the nanocrystal [42]. According to the findings [43], europium-doped hydroxyapatite synthesised at low temperature presents emission lines attributed for Ca 2+ (I) substitution similar to the emission spectrum of the heat-treated HA:Eu shown in Figure 11.…”

Section: Ha1200ssupporting

confidence: 59%

Structural and Luminescent Properties of Europium-Doped and Undoped Hydroxyapatite Powders Sintered by Spark Plasma

Domínguez

Garrido-Hernández

Montes

et al. 2019

Ceramics - Silikaty

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This paper studies the structural and photoluminescent properties of hydroxyapatite (HA) and europium-doped hydroxyapatite (HA:Eu) synthesised by the hydrothermal method and sintered by the spark plasma sintering (SPS) technique. HA and HA:Eu powders, synthesised at pH of 10, 11 and 12, were characterised by means of infrared spectroscopy, X-ray diffraction, scanning electron microscopy, Raman spectroscopy and luminescence spectroscopy. The HA and HA:Eu samples were sintered using the SPS technique at 900 and 1200 °C. It was determined that the HA and HA:Eu powders crystallised in the hexagonal phase, which is stable until 900 °C. The presence of Eu 3+ ions tended to stabilise the hexagonal phase of hydroxyapatite at 1200 °C. Undoped hydroxyapatite sintered at 1200 °C revealed a significant amount of tricalcium phosphate (β-TCP) as a result of its decomposition. By increasing the heat treatment temperature, different emission lines (

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Section: Ha1200ssupporting

confidence: 59%

Structural and Luminescent Properties of Europium-Doped and Undoped Hydroxyapatite Powders Sintered by Spark Plasma

Domínguez

Garrido-Hernández

Montes

et al. 2019

Ceramics - Silikaty

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“…An example of this type of crystalline elements are specific types of fluorophores, a.k.a RE-doped Apatite nanoparticles (REANPs). In particular, bioapatite has been shown to be very promising for biomedical applications because of its low toxicity level and high biocompatibility and biodegradability [20]. Apatite group is diffusely used as mineral and recently there have been several biomaterials based on apatite.…”

Section: Related Work and Motivationmentioning

confidence: 99%

“…For instance, fluorescent labeling has been shown as a fundamental tool in the study of complex biological interactions. Classical fluorescence cell labeling procedures were realized through the mean of fluorescent proteins, organic dyes, quantum dots, which present a series of disadvantages such as potential toxicity to the cells, simultaneous detection of multiple signals, and broad spectrum profile [20].…”

Section: Related Work and Motivationmentioning

confidence: 99%

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A Molecular Optical Channel Model Based on Phonon-Assisted Energy Transfer Phenomenon

Loscrì

Unluturk

Vegni

2018

IEEE Trans. Commun.

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Recent progress in the field of nanotechnology is enabling communication between nanodevices to be considered also for in-vivo applications. In particular, nanodevices enabling light-controlled process have started to attract a lot of interest in the research community, due to potential applications like healthcare wearable devices, intra-body applications and optogenetics, whose main objective is to stimulate neurons by the means of the light signals.Leveraging on these premises, we consider upconversion phenomenon, namely the ability of specific nanoparticles to convert low energy radiations (e.g., near-infrared radiations) into higher energy radiation (e.g., visible light) via a non-linear process. Energy transfer as viable communication mean has been already considered based on Förster-Resonance-Energy Transfer. In this paper, we focus on Phonon-Assisted Energy Transfer, and we analyze the requirements and conditions for generating optical signals from a genuine signal processing point of view. More specifically, based on information theory approach, we derive the conditions to minimize the error probability. We show that the dopant concentration (i.e., concentration of elements drugging a pure material in order to change its features) mostly influences the correct generation of the light signal. The performed analysis is based on experimental results taken from [1], [2].

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“…As reported and discussed by Perera et al, synthesis nanoparticles by coprecipitation method without high temperature calcination have attracted more attention for preparing nanohydroxyapatite; in this review, Perera et al mention several works reporting the synthesis of apatite materials doped with rare earths with excellent fluorescent properties but with micron sizes due to the high calcination temperatures needed to obtain crystalline powders [17]. The microwave-assisted synthesis is an excellent option to overcome the use of a high temperature calcination process but still there is a need for a simpler process [18].…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis, Characterization, and Cytotoxic Activity of Europium-Doped Nanohydroxyapatite

Miranda-Meléndez

Martínez-Castañón

Niño-Martínez

et al. 2016

Bioinorganic Chemistry and Applications

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The objective of this study was to synthetize europium-doped nanohydroxyapatite using a simple aqueous precipitation method and, thereafter, characterize and impregnate selected samples with 5-fluorouracil in order to explore the properties and the releasing capacity of this material. The nanohydroxyapatite was doped with 3, 5, 10, and 20 wt% of europium. The obtained samples were characterized after they were dried at 80°C and hydrothermal treated at 120°C by 2 hours. The samples were analyzed by transmission electron microscopy, X-ray diffraction analysis, Fourier transform infrared spectroscopy, and photoluminescence. Also, impregnation and release of 5-fluorouracil were assessed in PBS. The toxicity effects of all samples were studied using viability assays on human fibroblasts cells (HGF-1) in vitro. The sizes of the crystallites were about 10–70 nm with irregular morphology and present the phase corresponding to the JCPDS card 9–0432 for hydroxyapatite. The results of the toxicity experiments indicated that doped and undoped powders are biocompatible with fibroblasts cells. Hydroxyapatite samples doped with 5% of europium and loaded with 5-fluorouracil release almost 7 mg/L of the drug after 60 minutes in PBS and decrease the viability of HeLa cells after 24 hours.

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Rare Earth Doped Apatite Nanomaterials for Biological Application

Cited by 36 publications

References 56 publications

Structural and Luminescent Properties of Europium-Doped and Undoped Hydroxyapatite Powders Sintered by Spark Plasma

Structural and Luminescent Properties of Europium-Doped and Undoped Hydroxyapatite Powders Sintered by Spark Plasma

A Molecular Optical Channel Model Based on Phonon-Assisted Energy Transfer Phenomenon

Facile Synthesis, Characterization, and Cytotoxic Activity of Europium-Doped Nanohydroxyapatite

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