Rare tumour mimicking meninigioma: A case of primary intracranial amelanotic malignant melanoma with negative staining of S100 and HMB‐45

Abstract

Primary intracranial malignant melanoma is a rare disease, and the imaging findings usually mimic meningioma. Diagnosis is based on histology. Here, we report a case of primary intracranial malignant melanoma in a Chinese patient. A 27-year-old man presented with a 1-month history of headache. Magnetic resonance imaging findings resembled features of a meningioma. Craniotomy with tumour excision was done and confirmed to be S100 and human melanoma black 45-negative primary intracranial malignant melanoma. There was no extracranial involvement. The 9-month follow up was reported. To our knowledge, this is the first reported S100 and human melanoma black 45-negative primary intracranial amelanotic malignant melanoma.