Rarity of Ewing's Sarcoma in China

Li, FrederickP.; Tu, Ji-Tao; Liu, Fusheng; Shiang, ElaineL.

doi:10.1016/s0140-6736(80)91719-5

Cited by 49 publications

(31 citation statements)

References 2 publications

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“…A striking geographic and ethnic variation in incidence was initially reported in 1970 (Glass and Fraumeni 1970;Jensen and Drake 1970;Linden and Dunn 1970) and has more recently been confirmed (Li et al 1980;Poledak 1985;Parkin et al 1988). In contrast to the international variation in incidence of osteosarcoma, which appears to be low, that of Ewing's sarcoma varies over an order of magnitude, being lowest in Africa (Parkin et al 1988).…”

Section: Introductionmentioning

confidence: 85%

Interethnic polymorphism of EWS intron 6: genome plasticity mediated by Alu retroposition and recombination

et al. 1997

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The EWS gene has been identified as being systematically translocated in Ewing's sarcoma. In order to ascertain the basis of a marked interethnic difference in the incidence of Ewing's sarcoma, intron 6 of EWS, which is located near the translocation breakpoint region (EWSR1), was characterized. Sequence analysis of the entire intron 6 region revealed a very high density of Alu elements. Most of these Alu sequences could be classified in previously described subfamilies, facilitating delineation of an evolutionary model that involves successive retroposition events. According to this model, the EWS intron 6 region progressively expanded until about 5 million years ago. More recently (10(5) years ago), in part of the human population, the size of this region decreased by over 50% as the result of a homeologous recombination between two Alu sequences, which removed 2480 bp. This rare allele has only been observed in individuals of African origin, a population that is characterized by the lowest incidence of Ewing's sarcoma.

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Section: Introductionmentioning

confidence: 85%

Interethnic polymorphism of EWS intron 6: genome plasticity mediated by Alu retroposition and recombination

et al. 1997

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“…Approximately half of all patients are between 10 and 20 years of age at the time of first diagnosis, making this highly undifferentiated tumor the second most common primary malignant bone tumor in children and adolescents (Grier, 1997;Denny, 1998;Kovar, 1998;de Alava and Gerald, 2000;Paulussen et al, 2001). The frequency of occurrence in children is in the range of 1-3 per million per year in the Western hemisphere; interestingly, Ewing's sarcoma is slightly more frequent in males than females as well as more frequent in people of European than Chinese or African origin (Fraumeni and Glass, 1970;Young and Miller, 1975;Li et al, 1980;Stiller and Parkin, 1996;Zucman-Rossi et al, 1997;Hense et al, 1999;Cotterill et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

EWS–ETS oncoproteins: The linchpins of Ewing tumors

Janknecht

2005

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“…Ewing's sarcoma is extremely rare among blacks, both in Africa and in the U.S., 10 -13 and is seldom seen among Chinese. 14 Ionizing radiation is the only exogenous agent known to induce bone cancers in humans. Exposure to therapeutic radiation, to radon or radium intake, and to Thoratrast (a bone-seeking isotope) has resulted in the development of osteosarcoma as well as leukemia and lymphoma.…”

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confidence: 99%