2014
DOI: 10.1016/j.biochi.2014.08.009
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RARγ-C-Fos-PPARγ2 signaling rather than ROS generation is critical for all-trans retinoic acid-inhibited adipocyte differentiation

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Cited by 26 publications
(23 citation statements)
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“…ROS was detected by specific probe DHE as we previously described. 44,45 Briefly, the cells in specific dishes were stained with 10 μM DHE in serum-free DMEM medium (kept in the dark, 37°C) for 20 min. After washing twice with PBS, the cells were observed under a laser scanning confocal microscope (Olympus, FV10i).…”
Section: Discussionmentioning
confidence: 99%
“…ROS was detected by specific probe DHE as we previously described. 44,45 Briefly, the cells in specific dishes were stained with 10 μM DHE in serum-free DMEM medium (kept in the dark, 37°C) for 20 min. After washing twice with PBS, the cells were observed under a laser scanning confocal microscope (Olympus, FV10i).…”
Section: Discussionmentioning
confidence: 99%
“…Wang and cols. found that mouse adipocytes treated with all-trans-retinoic acid (ATRA) had higher RAR expression, RARg more so than RARα, with consequent decrease of PPARg expression (14). It is known that PPARg plays a role in GO development, and recently, we reported that OF from a GO patient treated with small doses of corticosteroid had higher PPARg gene expression.…”
Section: Discussionmentioning
confidence: 96%
“…The OF of GO patients express RA receptors, including RARα, and retinoids could inhibit adipocyte growth and differentiation, and induce apoptosis in these cells, consequently presenting therapeutic potential in GO (13,14). However, the development of severe GO has been associated with the simultaneous use of RA, recombinant thyroidstimulating hormone (TSH), and radioactive iodine (15).…”
Section: Introductionmentioning
confidence: 99%
“…Retinoic acid (RA) is a key regulator of cell differentiation in many contexts [50][51][52], functioning so as to control gene expression via activation of the RA receptor (RAR) and retinoid X receptor (RXR) families of nuclear hormone receptors [53]. RARγ activation has been shown to be important for inhibiting PPARγ2 expression in 3T3-L1 adipocyte differentiation [54]. This thus suggests that RARγ may be an important regulator of adipogenesis.…”
Section: Discussionmentioning
confidence: 99%