Rasio IgM/IgG Fase Akut Untuk Menentukan Infeksi Dengue Sekunder

Arhana, Bagus Ngurah Putu

doi:10.14238/sp8.1.2006.2-8

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Secondary infection causes viral antibody complexes in the body to be internalized by receptor carrier cells resulting in increased viral replication so that the severity of the disease can increase and can have a fatal impact on death. (Cáceres Munar, Castellanos Parra, & Rodríguez Panduro, 2019;Aryati, Wardhani, Rochaeni, Akualing, & Hadi, 2017;Arhana, 2016).…”

Section: History Of Denguementioning

confidence: 99%

Risk Factors of Dengue Mortality in Pamekasan District (2018-2020)

Zein

Ariyanto²,

Ersanti³

2022

JBE

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Background: The incidence of Dengue Haemoragic Fever (DHF) in the Pamekasan District is still high. Mortality of DHF was always happening in Pamekasan District from 2016 to 2020. Purpose: This study aims to analyze the risk factors of DHF mortality in the Pamekasan District (2018-2020). Methods: The study was conducted from October 2020-June 2021 with a case-control study. Total population was 293 cases. The sample was 54 respondents (1:2) with proportional random sampling. The inclusion criteria were families living under the same roof for a minimum of 17 years. The variables were dengue mortality, age, sex, education, history of DHF, comorbidities, access to health services, delay in treatment, family income, residence, and family knowledge. Data were collected through interviews and documentation study. The analysis in this study used univariate (frequency) and bivariate (crosstabs use OR). Results: Risk factors of DHF mortality in Pamekasan District are children (OR = 2.05; 95% CI=0.59-7.04), low education (OR=1.16; 95% CI=0.30-4.46), history of dengue (OR=3.57;95%CI=1.09-11.66), comorbidities(OR=17.50; 95% CI=4.25-72.05), difficult access to health services (OR=3.10; 95% CI=0.79-12.09), delay in treatment (OR=5.20;95% CI=1.50-18.0), low income family (OR=1.16; 95% CI = 0.30-4.46) and low of family knowledge about dengue (OR = 7.00; 95% CI = 1.99-24.58). Meanwhile, protective factors are female (OR = 0.70; 95% CI = 0.22-2.23) and rural (OR = 0.48 ; 95% CI = 0.13-1.73). Conclusion: Risk factors of DHF mortality in Pamekasan District (2018-2020) are the history of DHF, comorbidities, delay in treatment, and low family knowledge about DHF. ABSTRACT Background: The incidence of dengue fever in Pamekasan District is still high. Mortality of dengue was always happen in Pamekasan District since 2016 to 2020. Purpose: This study aimed to analyze the risk factors of dengue mortality in Pamekasan District (2018-2020). Methods: This research was case-control study. The study was conducted from October 2020-June 2021 in Primary Health Care selected at Pamekasan District. Total sample was 54 cases. Data was collected by interviews and documentation study. Analysis using uinvariate and bivariate (OR test). Results: Based on the results of OR test, risk factors of dengue mortality in pamekasan district (2018-2020) are: children (OR = 2.05 ; 95% CI = 0.59-7.04), education ≤ 9 yeras (OR = 1.16; 95% CI= 0.30-4.46), history of dengue (OR= 3.57 ; 95% CI = 1.09-11.66), comorbidities (OR=17.50; 95% CI=4.25-72.05), difficult access to health services (OR=3.10; 95% CI=0.79-12.09), delay in treatment (OR=5.20 ; 95% CI = 1.50-18.0), low income family (OR = 1.16; 95% CI = 0.30-4.46) and low of family knowledge about dengue (OR = 7.00; 95% CI = 1.99-24.58) while protective factors are : female (OR = 0.70; 95% CI = 0.22-2.23) and rural areas (OR = 0.48 ; 95% CI = 0.13-1.73). Conclusion: Risk factors of dengue mortality in Pamekasan District (2018-2020) are history of dengue, comorbidities, delay in treatment and low of family knowledge about dengue.

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Section: History Of Denguementioning

confidence: 99%

Risk Factors of Dengue Mortality in Pamekasan District (2018-2020)

Zein

Ariyanto²,

Ersanti³

2022

JBE

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“…Ratio IgM/IgG ≤ 0,9 pada fase akut dapat dijadikan prediktor infeksi dengue sekunder. 11 Hasil penelitian menyebutkan bahwa kadar OD serum yang menunjukkan hasil pemeriksaan IgG dengue serum positif terbanyak diperoleh dari responden pada hari demam ke-6 dan paling sedikit pada hari demam ke-5. Hasil ini hampir sama dengan hasil yang diperoleh pada penelitian yang dilakukan oleh Andreas dan koleganya.…”

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Diagnosis Dengue melalui Deteksi Antibodi Imunoglobulin G Spesifik dalam Sampel Urine dengan Teknik ELISA

2020

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Abstract. Dengue is a disease caused by dengue virus infection. Diagnosis of the disease is often difficult to be upheld just by the symptoms. Therefore, laboratory diagnostics is required. The general objective of this study was to detect dengue IgG in serum samples with rapid tests and in urine samples of suspected dengue patients using ELISA. The procedure of this study consisted of three stages. First, collecting urine samples from healthy individuals and collecting blood and urine samples from suspected dengue patients; second, examining dengue IgG in serum samples of suspected dengue patients with rapid tests; and third, examining dengue-specific IgG in urine samples from suspected dengue patients and from healthy individuals with ELISA technique. Data analyzed using experimental analytics to determine the cut off point used to interpret laboratory diagnostic results. The results showed that patients with positive serum dengue IgG test at the same time also showed positive results on the examination of dengue-specific IgG in their urine samples while patients with negative serum at the same time showed negative results on the examination of dengue-specific IgG in urine samples. Dengue-specific IgG examination in urine samples with ELISA technique can be used as an alternative examination in establishing the diagnosis of dengue, in which urine samples are taken from patients with more than 4 days fever. Keywords: Dengue, IgG, Urine, ELISA Abstrak. Dengue merupakan penyakit yang disebabkan virus dengue. Diagnosis penyakit ini sering sulit ditegakkan jika hanya melihat dari gejala. Oleh karena itu, diperlukan pemeriksaan laboratorium untuk penegakkan diagnosis. Tujuan umum penelitian ini adalah untuk mendeteksi IgG dengue dalam sampel serum dengan rapid tes dan pada sampel urine pasien terduga dengue dengan menggunakan metode ELISA. Prosedur penelitian ini terdiri dari tiga tahap. Pertama, pengumpulan sampel urine individu sehat dan pngumpulan sampel darah dan urine pada pasien terduga dengue; kedua, pemeriksaan IgG dengue dalam sampel darah pasien terduga infeksi dengue dengan rapid tes; dan ketiga, pemeriksaan IgG spesifik dengue pada sampel urine pasien terduga dengue dengan teknik ELISA, yang sebelumnya sudah dikelompokkan sesuai dengan hasil pemeriksaan IgG dengue pada sampel serum dengan rapid tes, dan pemeriksaan IgG spesifik dengue sampel urine individu sehat dengan teknik ELISA. Analitik eksperimental digunakan untuk menentukan cut off dari data yang kemudian digunakan untuk menafsirkan hasil diagnostik laboratorium. Hasil penelitian menunjukkan bahwa pada pasien dengan hasil pemeriksaan IgG dengue serum positif menunjukkan hasil positif juga pada pemeriksaan IgG spesifik dengue pada sampel urinnya, sedangkan pada hasil pemeriksaan serum yang negatif menunjukkan hasil negatif pula pada pemeriksaan IgG spesifik dengue di sampel urinnya. Pemeriksaan IgG spesifik dengue pada sampel urine dengan teknik ELISA dapat digunakan sebagai pemeriksaan alternatif dalam penegakan diagnosis dengue, di mana sampel urine diambil dari pasien dengan demam lebih dari 4 hari. Kata Kunci: Dengue, IgG, Urine, ELISA

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Detection of Proteinuria by Colorimetric Method and Correlation with Disease Severity in Patients Dengue

Charisma

Farida

Anwari

2021

Indonesian J. Clin. Pathol. Med. Lab.

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Severe dengue virus infection often causes proteinuria through several mechanisms, such as leakage of plasma proteins caused by higher protein filtering in the kidneys. The condition of proteinuria in patients with dengue shock syndrome will affect the management, prognosis, and mortality of patients with dengue virus infection. The objectives of this study were to determine the presence of protein in urine samples in patients in which IgG/IgM dengue was detected, to determine the presence of protein in urine samples in patients without dengue infection, and to determine the relationship between proteinuria in dengue patients and the degree of disease severity. The study was conducted in March-June 2020 at the Clinical Laboratory and Inpatient Clinic of Vita Medika Kepung, Kediri Regency. The method used was the consecutive sampling technique. The minimum sample size was 100 respondents with criteria for suspected dengue infection, onset fever > 4 days, age > 2 years, and no indication of other infectious diseases (blood and urine), divided into two groups, group with positive dengue infection and non-dengue group. The results showed that proteinuria was detected in 26% of respondents, secondary dengue infection and positive serological test of IgG, IgM only IgG were detected in 24 (92.3%) respondents and positive IgG and IgM were found in 2 (7.7%) respondents, this was shown by the p-value = 0.000 in the Chi-Square test with a Prevalence Ratio (PR) value of 11,987. In addition, Chi-Square test results indicated that a higher urine protein/albumin led to more severe disease, with p-value = 0.012 and 0.025 (p <0.05) and PR values of 3.333 and 2.800. The results of this study concluded that there was a close relationship between high levels of protein/albumin in the urine with the degree of disease severity in patients with dengue infection. In addition, an increase in urine protein/albumin levels is always followed by a decrease in serum protein/albumin levels.

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Rasio IgM/IgG Fase Akut Untuk Menentukan Infeksi Dengue Sekunder

Cited by 3 publications

References 2 publications

Risk Factors of Dengue Mortality in Pamekasan District (2018-2020)

Risk Factors of Dengue Mortality in Pamekasan District (2018-2020)

Diagnosis Dengue melalui Deteksi Antibodi Imunoglobulin G Spesifik dalam Sampel Urine dengan Teknik ELISA

Detection of Proteinuria by Colorimetric Method and Correlation with Disease Severity in Patients Dengue

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