Raspberry ketone and Garcinia Cambogia rebalanced disrupted insulin resistance and leptin signaling in rats fed high fat fructose diet

Attia, Reem T.; Abdel–Mottaleb, Yousra; Abdallah, Dalaal M.; El‐Abhar, Hanan S.; El-Maraghy, Nabila N.

doi:10.1016/j.biopha.2018.11.079

Cited by 45 publications

(41 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of ethanol was counteracted by both RK and omeprazole, this signifies the potential antioxidant gastroprotective activity of RK, via inducing Nrf2 expression. The effect of RK on Nrf2 was previously reported in the liver [23].…”

Section: Discussionmentioning

confidence: 81%

See 1 more Smart Citation

The implication of the crosstalk of Nrf2 with NOXs, and HMGB1 in ethanol-induced gastric ulcer: Potential protective effect is afforded by Raspberry Ketone

2019

View full text Add to dashboard Cite

Ethanol consumption is one of the common causative agents implicated in gastric ulcer development. Oxidative stress plays a major role in the induction and development of gastric ulceration. NADPH oxidases (NOXs) and Nuclear factor erythroid 2-related factor 2 (Nrf2) are key players in ethanol-induced ulcers. High-mobility group box 1 (HMGB1), a ubiquitous nuclear protein, mediates various inflammation functions. However, the role of HMGB1 in ethanol-induced gastric ulcer is not yet elucidated. Raspberry Ketone (RK) is a natural phenolic compound with antioxidant and anti-inflammatory properties. In the present study, absolute ethanol (7.5 ml/kg) was used to induce gastric ulceration in rats. Raspberry Ketone (RK) (50 mg/kg) was given orally one hour before the administration of absolute ethanol. Interestingly, ethanol-induced gastric ulcer was associated with Nrf2 downregulation, which was correlated with NOX-1, 2 NOX-4, and HMGB1 upregulation, and was significantly reversed by RK pre-treatment. RK pre-treatment provided 80% gastroprotection. Gastroprotective properties of RK were mediated via antioxidant, anti-inflammatory (suppression of NF-kB and tumor necrosis factor-α), and antiapoptotic activities (reduction of Bax/Bcl2 ratio). Gastroprotective properties of RK were confirmed by histopathological examination. In conclusion, this study is the first to provide evidence to the role of HMGB1 in ethanol-induced gastric ulcer, and the crosstalk of Nrf2, NOXs and HMGB1. It also demonstrates that RK represents a promising gastroprotective activity comparable to omeprazole.

show abstract

Section: Discussionmentioning

confidence: 81%

“…RK demonstrated protection in different animal models by decreasing lipid peroxidation and reducing inflammatory mediators such as TNF-α [21–24]. RK also showed to activate Nrf2 in a model of non-alcoholic fatty liver [23]. Thus, RK represents a promising active constituent that may protect against gastric ulceration.…”

Section: Introductionmentioning

confidence: 99%

The implication of the crosstalk of Nrf2 with NOXs, and HMGB1 in ethanol-induced gastric ulcer: Potential protective effect is afforded by Raspberry Ketone

2019

View full text Add to dashboard Cite

show abstract

“…Formulations were given orally by using oral feeding cannula and micropipette. Group A was orally administered with raspberry ketone suspension at a dose of 11 mg per 250 gm weight of rat [14,15] whereas group B received raspberry ketone nanoemulsion orally at a dose of 11 mg per 250 gm weight of rat. The rats were anesthetized using diethyl ether and blood samples (0.2 ml) were withdrawn from the retro-orbital eye vein of a rat at 0 (predose), 1, 2, 4, 6, 8 and 24 h. The samples were collected in EDTA coated micro centrifuge tubes.…”

Section: Pharmacokinetic Studiesmentioning

confidence: 99%

Nanoemulsion System for Improvement of Raspberry Ketone Oral Bioavailability

Singh¹,

Virmani²,

Kohli³

2020

IGJPS

View full text Add to dashboard Cite

“…For instance, drugs such as the antiviral favipiravir, which selectively inhibits RNA polymerase and prevents replication of the viral genome [2], the antimalarial hydroxychloroquine, which affects the binding of ACE2 and SARS-CoV2 spike protein, the antiparasitic ivermectin with nuclear transport inhibitory activity [3] and finally the anthelmintic niclosamide [4] have received attention as potential therapeutic agents tackling the virus through different mechanisms. Additionally, several well-known natural agents [5][6][7][8] such as curcumin, menthol, eriodictyol, thymoquinone, resveratrol, quercetin and raspberry ketone could potentially offer antiviral effects [9][10][11][12][13][14][15]. The combination of two to multiple agents could offer endless therapeutic options.…”

Section: -Introductionmentioning

confidence: 99%

In Search for Effective and Safe Drugs Against SARS-CoV-2: Part I] Simulated Interactions Between Selected Nutraceuticals, ACE2 Enzyme and S Protein Simple Peptide Sequences

Abdel‐Mottaleb

Abdel–Mottaleb²

2020

Preprint

Self Cite

View full text Add to dashboard Cite

Coronavirus disease (COVID-19) remains a world pandemic with little treatment options. Nature has provided a plethora of compounds that may offer potential protection and/or treatment choices. Earlier studies have shown a pivotal role of Angiotensin converting enzyme 2 (ACE2) in the pathogenesis of COVID-19. In this context, seven natural compounds were selected and their binding to specific peptide sequences of the coronavirus S-protein: ACE2 interface-drug binding adduct were calculated. Further to the natural drugs, we also similarly examined four well-known antiviral drugs. Moreover, the binding-interface of the isolated coronavirus S-protein and the isolated ACE2 receptor were also individually explored. The identified drug molecules positioned itself achieving geometries of minimum energy resulting in limiting viral recognition of host cells or to disturb host-virus interactions. The frontier orbitals (HOMO-LUMO) play crucial role in the binding interactions of the studied molecules. Most of the drugs act as electron sink whereas the S protein behaves as nucleophile. The results reported pave the way for the identification of small-drug molecule of natural origin with potentially tolerable side effects that can offer protection and/or treatment against coronavirus S-protein COVID-19. Experimental validation is of urgent demand.<br>

show abstract

Raspberry ketone and Garcinia Cambogia rebalanced disrupted insulin resistance and leptin signaling in rats fed high fat fructose diet

Cited by 45 publications

References 42 publications

The implication of the crosstalk of Nrf2 with NOXs, and HMGB1 in ethanol-induced gastric ulcer: Potential protective effect is afforded by Raspberry Ketone

The implication of the crosstalk of Nrf2 with NOXs, and HMGB1 in ethanol-induced gastric ulcer: Potential protective effect is afforded by Raspberry Ketone

Nanoemulsion System for Improvement of Raspberry Ketone Oral Bioavailability

In Search for Effective and Safe Drugs Against SARS-CoV-2: Part I] Simulated Interactions Between Selected Nutraceuticals, ACE2 Enzyme and S Protein Simple Peptide Sequences

Contact Info

Product

Resources

About