Rat behavior after chronic variable stress and partial lesioning of 5-HT-ergic neurotransmission: Effects of citalopram

Tõnissaar, Margus; Mällo, Tanel; Eller, Marika; Häidkind, Riina; Kõiv, Kristi; Harro, Jaanus

doi:10.1016/j.pnpbp.2007.08.001

Cited by 63 publications

(29 citation statements)

References 78 publications

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“…The duration of social interaction with an unfamiliar conspecific was significantly increased in chronically stressed animals irrespective of their exploratory phenotype. In singlehoused Wistar [30] and in group-housed Sprague-Dawley [53] male rats, a negative effect of CVS on social activity levels was found in the same testing conditions as used in the current study. However, in the abovementioned studies, even in the least active group, the time spent in social interaction was at least 2 times longer than in stressed animals in the present study, making an interstudy comparison impossible.…”

Section: Discussionsupporting

confidence: 61%

Activating Effects of Chronic Variable Stress in Rats with Different Exploratory Activity: Association with Dopamine D1 Receptor Function in Nucleus Accumbens

Matrov¹,

Vonk

Herm

et al. 2011

Neuropsychobiology

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Background/Aims: Rats display persistent behavioural phenotypes of low (LE) versus high (HE) exploratory activity in the exploration box paradigm. LE rats that prefer passive coping strategies show differential dopaminergic activity in the striatum. The main hypothesis of this study was that chronic variable stress (CVS) would have a higher impact on LE rats. Methods: Animals were submitted to a CVS regimen lasting 32 days that was followed by a behavioural test battery. The functional states of their dopamine D₁ and D₂ receptors were measured in the striatum and nucleus accumbens (NAcc). Cerebral oxidative metabolism was assessed via cytochrome c oxidase histochemistry in 65 brain regions. Results: CVS decreased weight gain, to a higher extent in LE rats, and lowered the sucrose preference after the first week, but habituation to the anhedonic effect had developed by the end of the experiment. CVS did not change the behavioural phenotypes initially assigned. No effect of stress on D₂ receptor function was found. Chronically stressed animals exhibited higher levels of social interaction and D₁ receptor-mediated cAMP accumulation in the NAcc, but not in the striatum. CVS was associated with higher oxidative metabolism levels in the anteroventral thalamus, median raphe nuclei and central periaqueductal grey matter. These changes after stress did not depend upon the exploratory phenotype. Conclusion: This study revealed changes in brain biochemistry after habituation to CVS that might be implicated in successful adaptation to chronic stress.

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Section: Discussionsupporting

confidence: 61%

Activating Effects of Chronic Variable Stress in Rats with Different Exploratory Activity: Association with Dopamine D1 Receptor Function in Nucleus Accumbens

Matrov¹,

Vonk

Herm

et al. 2011

Neuropsychobiology

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“…Actually, treatments causing cerebral 5-HT depletion such as p-chlorophenylalanine, p-chloroamphetamine (PCA), 5,7-dihydroxytryptamine, 3,4-methylenedioxy methamphetamine, and a tryptophan-free diet have been reported to induce aggression or anxiety in rodents (Ando et al, 2006;Bjork et al, 1998;Keele, 2001;Tõnissaar et al, 2008;Vergnes et al, 1986Vergnes et al, , 1988. PCA is well-known to be a potent serotonergic neurotoxin (Fuller, 1992).…”

Section: Discussionmentioning

confidence: 99%

Partial agonistic effect of yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells

Terawaki

Ikarashi

Sekiguchi

et al. 2010

Journal of Ethnopharmacology

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“…Following this training session, rats were tested the following day for five minutes. Two observers blind to treatment group scored the latency to the first float, time spent struggling, and the number of dives which previous studies have described as escape or active coping behavior [8; 28]. Latency to first float was defined as the rat's limbs remaining motionless for at least two seconds.…”

Section: Methodsmentioning

confidence: 99%

Exposure to repeated maternal aggression induces depressive-like behavior and increases startle in adult female rats

Bourke

Neigh

2012

Behavioural Brain Research

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The stress response is a multifaceted physiological reaction that engages a wide range of systems. Animal studies examining stress and the stress response employ diverse methods as stressors. While many of these stressors are capable of inducing a stress response in animals, a need exists for an ethologically relevant stressor for female rats. The purpose of the current study was to use an ethologically relevant social stressor to induce behavioral alterations in adult female rats. Adult (postnatal day 90) female Wistar rats were repeatedly exposed to lactating Long Evans female rats to simulate chronic stress. After six days of sessions, intruder females exposed to defeat were tested in the sucrose consumption test, the forced swim test, acoustic startle test, elevated plus maze, and open field test. At the conclusion of behavioral testing, animals were restrained for 30 minutes and trunk blood was collected for assessment of serum hormones. Female rats exposed to maternal aggression exhibited decreased sucrose consumption, and impaired coping behavior in the forced swim test. Additionally, female rats exposed to repeated maternal aggression exhibited an increased acoustic startle response. No changes were observed in female rats in the elevated plus maze or open field test. Serum hormones were unaltered due to repeated exposure to maternal aggression. These data indicate the importance of the social experience in the development of stress-related behaviors: an acerbic social experience in female rats precipitates the manifestation of depressive-like behaviors and an enhanced startle response.

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Rat behavior after chronic variable stress and partial lesioning of 5-HT-ergic neurotransmission: Effects of citalopram

Cited by 63 publications

References 78 publications

Activating Effects of Chronic Variable Stress in Rats with Different Exploratory Activity: Association with Dopamine D1 Receptor Function in Nucleus Accumbens

Activating Effects of Chronic Variable Stress in Rats with Different Exploratory Activity: Association with Dopamine D1 Receptor Function in Nucleus Accumbens

Partial agonistic effect of yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells

Exposure to repeated maternal aggression induces depressive-like behavior and increases startle in adult female rats

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