Rat Epigastric Flap Survival and VEGF Expression after Local Copper Application

Frangoulis, Marios; Georgiou, Panagis; Chrisostomidis, Chrisostomos; Περρέα, Δέσποινα; Dontas, Ismene; Kavantzas, Nikolaos; Kostakis, A.; Papadopoulos, Othon

doi:10.1097/01.prs.0000252000.59231.5e

Cited by 43 publications

(31 citation statements)

References 28 publications

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“…In addition to BG, other materials are under investigation with regards to their potential to promote angiogenesis. A direct role of copper to facilitate angiogenesis has been known for more than two decades (38,39), and the capacity of copper sulfate to promote wound healing has been linked to the upregulation of VEGF by stimulated cells, thereby increasing angiogenesis and enhancing the local oxygen microenvironment (40,41). These findings suggest promising new strategies to induce desired vascularization that could potentially be used in concert with other biomaterials.…”

Section: Discussionmentioning

confidence: 97%

Proangiogenic Potential of a Collagen/Bioactive Glass Substrate

2007

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Section: Discussionmentioning

confidence: 97%

Proangiogenic Potential of a Collagen/Bioactive Glass Substrate

2007

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“…VEGF pathway activation results in growth promotion, migration and differentiation of endothelial cells from existing blood vessels ( Figure 1) [30]. Cu could dramatically induce VEGF protein and its mRNA expression that was demonstrated in cell cultures and animal models [31,32]. Recently, additional findings demonstrate that tumor growth and metastasis depend upon angiogenesis [33,34] that requires growth factors, proteases, and trace element Cu.…”

Section: Role Of Cu In Angiogenesis and Cancer Progressionmentioning

confidence: 99%

New uses for old copper-binding drugs: converting the pro-angiogenic copper to a specific cancer cell death inducer

Chen

Dou

2008

Expert Opinion on Therapeutic Targets

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Background-The conventional approach toward anticancer drug development is a timeconsuming and expensive procedure.Objective/methods-One approach to expedite this process and achieve more affordable means is to discover new applications of existing drugs, since their pharmacokinetics and pharmacological profiles are well known.Results-Our encouraging findings in recent studies reveal anticancer activities of several copper-binding ligands including disulfiram (an antialcoholism drug), clioquinol (used to treat Alzheimer's and Huntington's diseases) and diethyldithiocarbamate (an agent for HIV-1 infection treatment). Conclusion-These in vitro and in vivo studies have demonstrated that these archaic drugs cantarget and react with tumor cellular copper, forming complexes that act as potent proteasome inhibitors and apoptosis inducers.

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“…It is well known that copper is a potent angiogenic factor but the mechanism whereby it exerts this function is still not well understood. Endothelial cells are induced to become more mobile when incubated with copper(II) [24] and topical application of copper(II) ions stimulated collagen synthesis, accelerated wound closure in mice and rat epigastric flap survival [25,26]. On the whole these data have led to development of anti-copper-based, antiangiogenic strategies for the treatment of cancer [27].…”

Section: Introductionmentioning

confidence: 99%