Rat intestinal epithelial cells present major histocompatibility complex allopeptides to primed T cells

Brandeis, Judson M.; Sayegh, Mohamed H.; Gallon, Lorenzo; Blumberg, Richard S.; Carpenter, Charles B.

doi:10.1016/0016-5085(94)90560-6

Cited by 41 publications

(10 citation statements)

References 26 publications

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“…These cells were suppressive functionally and in humans did not express the cytolytic proteins perforin and granzyme. Several studies have documented the capacity of normal IECs to take up soluble antigens in vitro and in vivo 20–25. Thus, there is evidence to support the contention that IECs might function as unique APCs in mucosal immune responses.…”

Section: Introductionmentioning

confidence: 96%

Activation of a Unique Population of CD8⁺ T Cells by Intestinal Epithelial Cells

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Brimnes

Shao

et al. 2004

Annals of the New York Academy of Sciences

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Intestinal epithelial cells may play a role in the regulation of immune responses toward luminal antigens. We show that a subset of CD8(+) T cells undergoes oligoclonal expansion in the intestinal mucosa, probably through interaction with a unique complex expressed on epithelial cells, formed by a CEA subfamily member (gp180) and CD1d. This subset, which is regulatory in vitro, may play a role in the control of intestinal immune responses toward luminal antigens. A lack of expansion of these CD8(+) regulatory T cells, probably related to the defective expression of the gp180/CD1d complex, is observed in inflammatory bowel disease.

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Section: Introductionmentioning

confidence: 96%

Activation of a Unique Population of CD8⁺ T Cells by Intestinal Epithelial Cells

Allez

Brimnes

Shao

et al. 2004

Annals of the New York Academy of Sciences

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“…[24] In mucosal immune responses, normal intestinal epithelial cells, the unique non-dendritic cell, non-monocyte, or non-B cell specialized antigen presenting cells (APCs), could express major histocompatibility complex class II molecules constitutively, expressing some critical costimulatory molecules, such as gp180, [25] to activate certain peripheral blood CD8 + T cells selectively for a suppressor function. [26,27] Furthermore, Raffaello et al [28] have demonstrated for the first time that not only can circulating CD8 + CD28 – suppressor T cells (Ts) be involved in the differentiation of tolerogenic APCs, but they can also suppress the T h cell response via contact mediated by APCs, implying that CD8 + CD28 – suppressor T cells participate in the maintenance of peripheral tolerance. It has been confirmed that a lack of suppressor T cells (including CD8 + CD28 – T cells) induced by intestinal epithelial cells is relevant to IBD.…”

Section: Discussionmentioning

confidence: 99%

Decreased CD8+CD28+/CD8+CD28– T cell ratio can sensitively predict poor outcome for patients with complicated Crohn disease

Dai

et al. 2017

Medicine

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Crohn disease (CD) with complications such as penetrating, stricturing, and perianal disease is called complicated CD. The aim of this study is to test the efficiency with which the CD8+CD28+/CD8+CD28– cell balance can predict a subsequent active stage in patients with newly diagnosed complicated CD.Seventeen patients with complicated CD and 48 CD patients with no complications were enrolled. Blood CD8+ T cells were tested from all of the 65 newly diagnosed CD patients upon enrollment. The potential risk factors were compared between the 2 groups. A 30-week follow-up was performed, and the efficiency of the CD8+ cell balance at predicting active CD was analyzed using receiver-operating characteristic curves. The cumulative remission lasting rates (CRLRs) were analyzed using the Kaplan–Meier method.Compared with the control CD group, patients with complicated CD were predominantly male and younger in age; they also had lower body mass indices (BMIs), higher Crohn disease activity indices (CDAIs), higher immunosuppressant and steroid prescription rates, and significantly higher surgical rates. The CD8+CD28+/CD8+CD28– balance was associated with BMI, CDAI, steroids, and surgery. The CD8+CD28+/CD8+CD28– ratios were significantly lower at week 0 and on the 6th, 22nd, and 30th week during follow-up with a shorter lasting time of remission for the complicated CD patients. The CD8+CD28+/CD8+CD28– ratio could accurately predict the active stage for the patients with complicated CD, and the highest sensitivity (89.2%) and specificity (85.3%) were found when the ratio was 1.03. Treatment with steroids and surgery, along with a significantly lower CD8+CD28+/CD8+CD28– ratio and lower CRLRs, was closely related to a worse outcome for the patients with complicated CD.Patients requiring steroids and surgery experience more severe disease activity and thus a disequilibrated immunological balance, which could be the main reason for a decreased CD8+CD28+/CD8+CD28– ratio. This ratio can sensitively predict the active stage for patients with complicated CD, and more care should be taken when this ratio is <1.03.

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“…This process was rather slow, and no attempt to define processing of the protein was made. Brandeis et al, (1994) fed rats class II peptides in an effort to promote oral tolerance to alloantigen (Brandeis et al, 1994). This group was able to document the presence of these peptides in small bowel epithelium 6 h after ingestion.…”

Section: Peptide Antigen Uptake By Intestinal Epithelial Cellsmentioning

confidence: 92%

Role of Epithelial Cells in Antigen Presentation

2015

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Rat intestinal epithelial cells present major histocompatibility complex allopeptides to primed T cells

Cited by 41 publications

References 26 publications

Activation of a Unique Population of CD8⁺ T Cells by Intestinal Epithelial Cells

Activation of a Unique Population of CD8⁺ T Cells by Intestinal Epithelial Cells

Decreased CD8+CD28+/CD8+CD28– T cell ratio can sensitively predict poor outcome for patients with complicated Crohn disease

Role of Epithelial Cells in Antigen Presentation

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Rat intestinal epithelial cells present major histocompatibility complex allopeptides to primed T cells

Cited by 41 publications

References 26 publications

Activation of a Unique Population of CD8+ T Cells by Intestinal Epithelial Cells

Activation of a Unique Population of CD8+ T Cells by Intestinal Epithelial Cells

Decreased CD8+CD28+/CD8+CD28– T cell ratio can sensitively predict poor outcome for patients with complicated Crohn disease

Role of Epithelial Cells in Antigen Presentation

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Activation of a Unique Population of CD8⁺ T Cells by Intestinal Epithelial Cells

Activation of a Unique Population of CD8⁺ T Cells by Intestinal Epithelial Cells