Rate of Pathology From Atypical Glandular Cell Pap Tests Classified by the Bethesda 2001 Nomenclature

DeSimone, Christopher P.; Day, Misty E.; Tovar, Molly M.; Dietrich, Charles S.; Eastham, Mary L.; Modesitt, Susan C.

doi:10.1097/01.aog.0000218705.87329.4a

Cited by 61 publications

(55 citation statements)

References 21 publications

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“…However, such a policy could lead to overtreatment, with its surgical and reproductive morbidities, especially in young women. Moreover, BNCs in women over 35 years are more likely to be endometrial in origin, that is, hyperplasias and carcinomas (DeSimone et al , 2006). In our study, 24% of over 35s compared to 49% of under 35s had high-grade histology.…”

Section: Discussionmentioning

confidence: 99%

Management of borderline change in endocervical cells: a more dependable approach

et al. 2014

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Background:There are limited data and guidance from the UK on borderline nuclear change in endocervical cells (BNCs). The objective of this study is to determine the clinical outcome of women with BNCs, to determine the accuracy of colposcopy and propose a more robust management algorithm.Methods:This is a retrospective review of all BNC referrals between January 2006 and December 2011 at the Northumbria Healthcare Trust. Histological diagnosis was based on high-grade histology (CIN 2 or worse). Any high-grade histology in the first year of follow-up was included in the final diagnosis.Results:Of the 9001 new referrals, 167 women had BNCs. Thirty-seven (22%) were diagnosed with high-grade histology on initial assessment. Sixty women had satisfactory and negative colposcopy, out of which 7 (12%) were detected with high-grade histology/cytology in the first year of follow-up. Overall, 50 high-grade histology (30%), including two invasive carcinomas were detected.Conclusions:Current follow-up of BNCs relies heavily on colposcopic assessment. A significant proportion of women with negative colposcopy was found to have high-grade histology in the first year of follow-up. We propose a more robust management algorithm to lower the probability of missed high-grade histology in this subgroup of women.

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Section: Discussionmentioning

confidence: 99%

Management of borderline change in endocervical cells: a more dependable approach

et al. 2014

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“…21 Approximately 50% of women with AGC on routine screening will have no underlying pathology on subsequent sampling. [14][15][16] Multiple studies have examined the role of HPV testing in the triage of AGC. [17][18][19][20]22 A recent study demonstrated that AGC lesions testing positive for HR-HPV by Hybrid Capture 2 (Digene corp) DNA probe are more likely to represent HSIL rather than AIS on follow-up compared to those that are negative for HPV.…”

Section: Discussionmentioning

confidence: 99%

Atypical glandular cells (AGC): ThinPrep Imaging System (TIS), manual screening (MS), and correlation with Hybrid Capture 2 (HC2) HPV DNA testing

Sireci

Crapanzano

Mansukhani

et al. 2009

Diagnostic Cytopathology

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“…Additional endometrial sampling is recommended in women 35 years of age or older, and in women at risk of endometrial neoplasia. In the literature, the incidence of significant lesion in women with AGC-NOS varies from 5% to 33% (Haidopoulos et al, 2005;DeSimone et al, 2006;Behtash et al, 2007;Westin et al, 2008;Adhya et al, 2009;Schnatz et al, 2009;Zhao et al, 2009) as compared with 41%-70% in women with AGC-FN smears (Haidopoulos et al, 2005;DeSimone et al, 2006;Westin et al, 2008;Adhya et al, 2009;Schnatz et al, 2009). Extragenital malignant lesions were found in less than 1% of women with AGC cytology (Zhao et al, 2009).…”

Section: Atypical Glandular Cellsmentioning

confidence: 99%

Histopathological Outcomes of Women with Abnormal Cervical Cytology: a Review of Literature in Thailand

Kietpeerakool¹,

Tangjitgamol²,

Srisomboon³

2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (16), 6489-6494 IntroductionCervical cancer remains the major health problem in Thailand and many other developing countries. This is mainly because of failure to initiate or sustain effective screening strategy. In recent population-based cancer registries, the highest incidence of cervical cancer in Thailand was noted in Chiang Mai with an average agestandardized incidence rate (ASR) of 28.9 per 100000, followed by Lampang (ASR, 22.4) and Bangkok (ASR, 20.9) (Moore et al., 2010).Although high-risk Human Papillomavirus (HR-HPV) test and HPV genotyping have certain role in cervical cancer screening nowadays, these tests are not widely available in developing countries. Cervical cytology is still the principal screening method. Subsequent management of abnormal cervical cytology to detect underlying cervical lesions is also important. Generally, management of abnormal cervical cytology depends on the risk of encountering high-grade cervical disease. However, the risks of high-grade cervical disease encountered in abnormal cervical cytology may vary among different regions of the world and across the country. Therefore, information regarding the incidence of significant cervical disease from different areas or populations is crucial for designing and implementing area-specific management approach. This review was conducted to evaluate the incidence of high-grade cervical diseases among Thai AbstractCervical cytology remains the principal screening method to detect pre-invasive and invasive cervical lesions. Management of abnormal cervical cytology depends on the risk of encountering a significant cervical lesion or high-grade cervical disease. These risks may vary in different areas across the country. Thus, determining the rate of significant cervical lesion associated with each type of abnormal cervical cytology in each area is of critical importance for designing area-specific management approach. This review was conducted to evaluate the rate of high-grade cervical disease among Thai women with abnormal cervical cytology. A relatively high incidence of underlying significant lesions including invasive disease was demonstrated even in those having only minimal smear abnormality. This baseline information is crucial and must be taken into consideration in management of women with abnormal cytological screening to achieve the goals of comprehensive cervical cancer control in Thailand.

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Rate of Pathology From Atypical Glandular Cell Pap Tests Classified by the Bethesda 2001 Nomenclature

Abstract: II-2.

Cited by 61 publications

References 21 publications

Management of borderline change in endocervical cells: a more dependable approach

Management of borderline change in endocervical cells: a more dependable approach

Atypical glandular cells (AGC): ThinPrep Imaging System (TIS), manual screening (MS), and correlation with Hybrid Capture 2 (HC2) HPV DNA testing

Histopathological Outcomes of Women with Abnormal Cervical Cytology: a Review of Literature in Thailand

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