Rates of depletion of linoleic acid from fat depots of selected lines of mice differing in growth rate and adiposity

Eisen, E. J.; Cartwright, A. L.; Weller, Karsten; Smith, Kendon

doi:10.1007/bf02535093

Cited by 9 publications

(1 citation statement)

References 26 publications

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“…Cafeteria-fed obese mice gained much more than CF control mice when compared with the mice on other treatments within each line. This may be attributed to the obese mice having a greater appetite, higher lipogenic activity and lower fat turnover (Eisen et al, 1982). Also PM obese mice gained more than RE obese mice, but this difference did not occur in the control PM vs RE mice.…”

Section: Resultsmentioning

confidence: 91%

Effects of Feeding Pattern and Dietary Regimen on Growth and Adipose Tissue Cellularity in Polygenic Obese Mice

Plucinski

Bruner

Leatherwood

et al. 1984

Journal of Animal Science

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The effect of varying feed intake and feeding pattern during the early postweaning period on growth, body composition and adipose tissue cellularity was studied in polygenic obese and control normal mice. Male mice were assigned to the following dietary treatments at 4.5 wk of age: stock diet fed ad libitum(AL), four palatable foods cafeteria-fed(CF), stock diet fed every 2 h by automatic feeders adjusted for maximum intake(MI), fed same procedure as MI but restricted to produce 70% of the gain of mice fed ad libitum(RE), and stock diet fed one meal/d the same amount fed RE mice(PM). Mice were killed after 5 wk on treatment. Cafeteria-fed control mice were heavier (P less than .05) than RE control mice, but they were not different (P greater than .05) from AL, MI and PM control mice, while CF obese mice were heavier and RE obese mice were smaller than AL, MI and PM obese mice (P less than .05). Cafeteria-fed mice were fatter than mice from all other treatments in both the obese and control lines. Maximum intake, PM and RE mice were fatter than AL mice but this effect was only significant in the obese line. Alterations in feeding pattern can affect body composition even though body weight may not show a correlated response. Cafeteria-fed obese mice had larger fat pads and more small (less than 40 micron) and large (greater than 110 micron) adipocytes than other obese mice. Results indicate that the difference in the development of obesity on cafeteria diet was due primarily to genetic effects while the increase in percentage fat after restriction on MI, PM and RE treatments was due mainly to the acute change of feeding pattern.

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Section: Resultsmentioning

confidence: 91%

Effects of Feeding Pattern and Dietary Regimen on Growth and Adipose Tissue Cellularity in Polygenic Obese Mice

Plucinski

Bruner

Leatherwood

et al. 1984

Journal of Animal Science

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Selection for different growth parameters in laboratory mice and its correlated effects on body composition and organ weights

Bünger

Remus²,

Roschlau

1985

Nahrung

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Body composition and organ weights were determined in male mice sampled from 4 different lines of a selection experiment: DU-6P (selected for high protein amount), DU-6 (selected for high body weight), DU-6 + LB (selected for an index combining body weight and endurance fitness) and DU-K (unselected control line). Selection was carried out under the conditions of ad libitum feeding and standardization of litter size at birth. In all 3 selection lines a significant direct selection response was shown. While fat in lines DU-6P and DU-6 + LB remained normal, it increased after selection for body weight (DU-6) significantly. Up to generation 13 the average increase of fat was 0.32% per generation. Investigations on 28 to 80 days old mice showed, that males of this line were fatter before, at and after the age of selection (42 days). After 9 generations the body weight of selected mice was significantly increased by 23 to 29%. The absolute organ weights of hearts, livers and kidneys were also significantly higher, while the relative weights of hearts and kidneys decreased. The relative liver weights were in the selected lines higher, but only the difference DU-6 vs. DU-K was significant.

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Adipocyte fatty acid mobilization in vivo: Effects of age and anatomical location

Hartman

1985

Lipids

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The objectives of the present study were to determine if adipocyte triglyceride fatty acid (TGFA) mobilization in vivo varied among the different adipose tissue depots and whether these rates were affected by age. In order to accomplish these objectives, two groups of rats were studied. The first group initially weighed 84 +/- 1 and the second group 333 +/- 2. Both groups were placed on a semisynthetic diet containing 6% corn oil (w/w) and 14% triundecanoin (w/w) for a period of 4 wk. Triundecanoin contains an 11-carbon (C-11) fatty acid (undecanoic acid) that was used to label the adipocyte TGFA. At the end of the 4-wk feeding period, triundecanoin was removed from the diet and replaced with an equivalent amount of corn oil. At this time and at weekly intervals for the next 4 wk, 5 rats from each age group were killed for the determination of TGFA composition in isolated adipocytes from the epididymal (Epi), perirenal (PR), subcutaneous (SC) and mesenteric (M) adipose tissue depots. When the content of C-11 was expressed as mole percent of the total fatty acids, mobilization was significantly more rapid from the PR and M depots than in the other two depots in the young rats. In the older rats mobilization was significantly slower in all depots compared to the younger group. The rates of mobilization were not different between the depots in the older animals. Since fat cell size continued to increase throughout the duration of the study, part of the decrease in C-11 content can be accounted for by dilution by newly acquired TGFA.(ABSTRACT TRUNCATED AT 250 WORDS)

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Rates of depletion of linoleic acid from fat depots of selected lines of mice differing in growth rate and adiposity

Cited by 9 publications

References 26 publications

Effects of Feeding Pattern and Dietary Regimen on Growth and Adipose Tissue Cellularity in Polygenic Obese Mice

Effects of Feeding Pattern and Dietary Regimen on Growth and Adipose Tissue Cellularity in Polygenic Obese Mice

Selection for different growth parameters in laboratory mice and its correlated effects on body composition and organ weights

Adipocyte fatty acid mobilization in vivo: Effects of age and anatomical location

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