Rates of intestinal absorption of molybdenum in humans

Giussani, A.; Arogunjo, A.M.; Cantone, M.C.; Tavola, Federico; Veronese, I.

doi:10.1016/j.apradiso.2005.12.013

Cited by 17 publications

(14 citation statements)

References 24 publications

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“…When added to a beverage containing starch, dextrimaltose, oil, sucrose, α-cellulose and minerals, the absorption efficiency of increasing doses of 100 Mo ranging from 24 to 1 378 µg was between 90 and 94 % in healthy men Turnlund, 2006, 2007). Black tea has been shown to considerably reduce molybdenum absorption upon ingestion of relatively high amounts of molybdenum (0.5-1 mg as a single dose of stable isotope) (Giussani et al, 2006;Giussani et al, 2007). In ten premature infants, absorption of the stable isotope 100 Mo from infant formula was 97.5 % (96.3-99.1 %) after receiving 25 µg molybdenum/kg body weight (Sievers et al, 2001).…”

Section: Intestinal Absorptionmentioning

confidence: 99%

“…Intravenously infused molybdenum disappears rapidly from the blood; depending on the tracer dose given, the plasma tracer concentration was approximately halved or even lower within two hours after injection (Cantone et al, 1995;Giussani et al, 2006).…”

Section: Transport In Bloodmentioning

confidence: 99%

“…Molybdenum absorption in the presence of solid foods (cress, green salad, tomatoes, bean soup) is lower compared to administration with water (Giussani et al, 2006;Giussani et al, 2007). When added to a beverage containing starch, dextrimaltose, oil, sucrose, α-cellulose and minerals, the absorption efficiency of increasing doses of 100 Mo ranging from 24 to 1 378 µg was between 90 and 94 % in healthy men Turnlund, 2006, 2007).…”

Section: Intestinal Absorptionmentioning

confidence: 99%

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Scientific Opinion on Dietary Reference Values for molybdenum

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2013

EFSA Journal

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Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for molybdenum. Molybdenum is efficiently and rapidly absorbed at a wide range of intakes, and the body is able to maintain homeostasis through the regulation of excretion via the urine. Molybdenum deficiency in otherwise healthy humans has not been observed and there are no biomarkers of molybdenum status. Various metabolic balance studies have been performed to establish molybdenum requirements. However, only one balance study, which was performed with a constant diet and under controlled conditions in adult men, was considered to be of sufficient duration. In this small study, balance was reported to be near zero when molybdenum intakes were 22 µg/day. Biochemical changes or symptoms suggestive of molybdenum deficiency were not observed, and it is possible that humans may be able to achieve molybdenum balance at even lower intakes. Data on molybdenum intakes and health outcomes were unavailable for the setting of DRVs for molybdenum. As the evidence required to derive an Average Requirement and a Population Reference Intake was considered insufficient, an Adequate Intake (AI) is proposed. Observed molybdenum intakes from mixed diets in Europe were taken into consideration in setting this value. An AI of 65 µg/day is proposed for adults; a figure that is based on molybdenum intakes at the lower end of the wide range of observed intakes. It is suggested that the adult AI also applies to pregnant and lactating women. An AI is also proposed for infants from seven months and for children based on extrapolation from the adult AI using isometric scaling and the reference body weights of the respective age groups. Molybdenum is an essential component of certain enzymes that catalyse redox reactions and contain, in addition to molybdenum, other prosthetic groups such as flavin adenine dinucleotide or haem. In humans, sulphite oxidase, xanthine oxidoreductase, aldehyde oxidase and mitochondrial amidoxime reducing component require molybdenum linked with a pterin (molybdopterin) as the cofactor. These enzymes are involved in the metabolism of aromatic aldehydes and the catabolism of sulphurcontaining amino acids and heterocyclic compounds, including purines, pyrimidines, pteridins and pyridines. © EuropeanIn humans, a single case report of a syndrome suggestive of dietary molybdenum deficiency in a patient on total parenteral nutrition for several months has been reported, but clinical signs of molybdenum deficiency in otherwise healthy humans have not been observed. A distinct molybdenum deficiency syndrome has not been observed in animals when subjected to molybdenum restriction, despite considerable reduction in the activity of molybdoenzymes.Water-soluble molybdates are efficiently and rapidly absorbed from the digestive tract at a wide range of intakes, and the body is able to adapt to this wide intake range by regulating excretion via the urine. Storage of ...

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Section: Intestinal Absorptionmentioning

confidence: 99%

Section: Transport In Bloodmentioning

confidence: 99%

Section: Intestinal Absorptionmentioning

confidence: 99%

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Scientific Opinion on Dietary Reference Values for molybdenum

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2013

EFSA Journal

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“…Molybdenum absorption from an aqueous solution was between 84 and 98% (Cantone et al, 1997;Giussani et al, 2006). Food matrix was observed to affect molybdenum absorption (Cantone et al, 1997;Giussani et al, 2006;Turnlund et al, 1999;Werner et al, 1998), with a decrease of between 16 and 43% observed with solid food compared with molybdenum delivery in an aqueous solution.…”

Section: Nutrient Interactions and Bioavailability (Table 4)mentioning

confidence: 99%

“…Food matrix was observed to affect molybdenum absorption (Cantone et al, 1997;Giussani et al, 2006;Turnlund et al, 1999;Werner et al, 1998), with a decrease of between 16 and 43% observed with solid food compared with molybdenum delivery in an aqueous solution. Black tea was identified as an inhibitor of absorption by two of the studies, reducing absorption by a factor of between 5 and 10 (Giussani et al, 2006;Werner et al, 1998).…”

Section: Nutrient Interactions and Bioavailability (Table 4)mentioning

confidence: 99%

Literature search and review related to specific preparatory work in the establishment of Dietary Reference Values ‐ Preparation of an evidence report identifying health outcomes upon which Dietary Reference Values could potentially be based for chromium, manganese and molybdenum

Mullee

Brown

Collings

et al. 2012

EFSA Supporting Publications

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Molybdenum

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Aveyard²,

Carey

et al. 2023

Patty's Toxicology

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Molybdenum is an essential element for humans, animals, and plants. But excess exposure to molybdenum substances may cause harmful effects. This chapter describes natural occurrence, production, uses, and chemical and biochemical properties of molybdenum substances, and possible adverse effects in relation to dose. The emphasis is on commercial inorganic molybdenum substances and those where the molybdate ion [MoO 4 ] 2− is the driver for a biological effect.

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Rates of intestinal absorption of molybdenum in humans

Cited by 17 publications

References 24 publications

Scientific Opinion on Dietary Reference Values for molybdenum

Scientific Opinion on Dietary Reference Values for molybdenum

Literature search and review related to specific preparatory work in the establishment of Dietary Reference Values ‐ Preparation of an evidence report identifying health outcomes upon which Dietary Reference Values could potentially be based for chromium, manganese and molybdenum

Molybdenum

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