Rates of Senile Dementia—Alzheimer's Type in the Baltimore Longitudinal Study

Sayetta, Rona B.

doi:10.1016/0021-9681(86)90049-4

Cited by 72 publications

(27 citation statements)

References 23 publications

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“…One study (Geerlings et al, 1997) used a community sample with a demented group within it, but did not report a direct comparison. We also excluded studies (Jarvik et al, 1980;Sayetta, 1986) which studied volunteer samples. We included the Fredman (1999) study which is an exclusively female sample.…”

Section: Resultsmentioning

confidence: 99%

Dementia, cognitive impairment and mortality in persons aged 65 and over living in the community: a systematic review of the literature

Dewey

Saz²

2001

Int J Geriat Psychiatry

267

145

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Levels of cognitive impairment commonly found in community studies give rise to an increased risk of mortality, and this appears to be true even for quite mild levels of impairment. The analysis confirms the increased risk of mortality for dementia, but reveals a dearth of information on the causes of the excess mortality and on possible effect modification by age, dementia subtype or other variables.

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Section: Resultsmentioning

confidence: 99%

Dementia, cognitive impairment and mortality in persons aged 65 and over living in the community: a systematic review of the literature

Dewey

Saz²

2001

Int J Geriat Psychiatry

267

145

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“…The development of 56 cases of dementia during 1,585 person-years of follow-up may be restated as an incidence rate of 3.53 cases per 100 person-yeats at risk (0.03531yr). A striking feature was that the number of cases of dementia was about the same as the number of heart attacks (50) in this same cohort during this time period and twice the number of cerebrovascuiar accidents (26). Table 1 shows the incidence of dementia and AD as a function of entry mentalstatus score.…”

Section: Deveiopment Of Dementiamentioning

confidence: 96%

Development of dementing illnesses in an 80‐year‐old volunteer cohort

Katzman

Aronson

Fuld

et al. 1989

Annals of Neurology

432

257

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We have prospectively followed over a 5-year period 434 volunteers who were at intake ambulatory, functional, presumably nondemented, and between 75 and 85 years of age. Fifty-six (an incidence of 3.53 per 100 person-years at risk) developed a progressive dementia: 32 met diagnostic criteria for Alzheimer's disease (AD) (an incidence of 2.0 per 100 person-years at risk), 15 had vascular or mixed dementia, and 9 had other disorders or remain undiagnosed. New cases of dementia were as common as myocardial infarction and twice as common as stroke. Risk factors for both dementia and AD were age (over 80) and gender (female); other reported risk factors such as family history, prior head injury, thyroid disease, maternal age, and smoking were not risk factors for AD in this elderly cohort. Prior stroke was the major risk factor for vascular or mixed dementia; diabetes and left ventricular hypertrophy but not a history of hypertension per se were also risk factors for vascular dementia. The major predictor of the development of AD was the mental status score on entry. The 58.5% of the cohort who made zero to two errors on a 33-item mental status test had a less than 0.6% per year chance of developing AD, whereas the 16% of the cohort with five to eight errors on this test developed AD at a rate of over 12% per year. Thus, it is possible to identify a large cohort of 80-year-olds who are at low risk for AD and a smaller cohort at very high risk.

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“…In one study, the Baltimore Longitudinal Study [10], LTR of AD was reported; however their sample was small with only 27 incident cases that were later reported as possibly misclassified [11]. Estimation of the cumulative risk of dementia and AD is different from the LTR estimates in that it does not account for the competing risk of death.…”

Section: Life-time Risk Of Ad and Strokementioning

confidence: 99%

Risk Estimations, Risk Factors, and Genetic Variants Associated with Alzheimer's Disease in Selected Publications from the Framingham Heart Study

Weinstein

Wolf

Beiser

et al. 2012

JAD

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The study of Alzheimer Disease (AD) in the Framingham Heart Study (FHS), a multi-generational, community-based population study, began nearly four decades ago. In this overview, we highlight findings from 7 prior publications that examined lifetime risk estimates for AD, environmental risk factors for AD, circulating and imaging markers of aging-related brain injury and explorations on the genetics underlying AD.

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Rates of Senile Dementia—Alzheimer's Type in the Baltimore Longitudinal Study

Cited by 72 publications

References 23 publications

Dementia, cognitive impairment and mortality in persons aged 65 and over living in the community: a systematic review of the literature

Dementia, cognitive impairment and mortality in persons aged 65 and over living in the community: a systematic review of the literature

Development of dementing illnesses in an 80‐year‐old volunteer cohort

Risk Estimations, Risk Factors, and Genetic Variants Associated with Alzheimer's Disease in Selected Publications from the Framingham Heart Study

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