Ratio of Pancreatic Duct Caliber to Width of Pancreatic Gland by Endosonography Is Predictive of Pancreatic Cancer

Eloubeidi, Mohamad A.; Luz, Letícia P.; Tamhane, Ashutosh; Khan, Mahboob; Buxbaum, James

doi:10.1097/mpa.0b013e31827305b8

Cited by 23 publications

(17 citation statements)

References 22 publications

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“…However, in pancreatic carcinoma patients, the ratio was increased to more than 0.5. This was confirmed by Eloubeidi et al [23]. Positive predictive value, negative predictive value, sensitivity, specificity, and accuracy of PDG greater than or equal to 0.34 for detecting cancer were 87, 99, 94, 97, and 97%, respectively.…”

Section: Characterization Of Pancreatic Massessupporting

confidence: 71%

Radiological Evaluation of Focal Pancreatic Lesions

Putzer¹,

Jaschke²

2014

Dig Dis

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The early and accurate characterization of pancreatic masses remains a challenge in diagnostic radiology, while the continuously evolving diagnostic possibilities give rise to an ever-increasing number of incidentally found pancreatic masses. This article discusses the relevance and role of ultrasound, endoscopic ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) in the diagnosis of pancreatic lesions. Specific protocols such as MR cholangiopancreatography and multiphase CT allow for a close characterization. While CT and MRI deliver information to further evaluate pancreatic disease, PET/CT has shown potential for staging purposes and in the clinical follow-up of pancreatic cancer patients. Common differential diagnoses regarding pancreatic cancer are discussed, and typical imaging features of anatomical variations, cystic lesions and pancreatitis are illustrated, together with clinical signs of pancreatic disease. The use of cross-sectional imaging in correlation with clinical features allows for an accurate and early detection of pancreatic masses and assists in differentiating benign from malignant disease.

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Section: Characterization Of Pancreatic Massessupporting

confidence: 71%

Radiological Evaluation of Focal Pancreatic Lesions

Putzer¹,

Jaschke²

2014

Dig Dis

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“…La topographie du cancer était majoritairement l'uncus et la tête du pancréas dans 61,2% (n=11), caudale dans 16,6% (n=3), isthmique et corporéale dans 11,1% (n=2), ce qui concorde bien avec les données de la littérature (26) (27).…”

Section: Discussionunclassified

“…L'excellente résolution en contraste de ces séquences permet de détecter les tumeurs de petite taille <2cm ne déformant pas les contours du pancréas, et les lésions isodenses difficilement repérables en TDM (29)(30)(31). L'IRM est également supérieure au scanner dans la détection (intérêt des séquences de diffusion) et surtout la caractérisation des métastases hépatiques, et elle est dans ce cadre recommandée en cas de tumeur présumée résécable à l'issue du bilan TDM s'il existe un doute sur la nature d'une ou plusieurs lésions hépatiques (27) En conclusion Même si le risque de survenue de cancer sur PCC reste faible, certains éléments sémiologiques permettent d'aider au diagnostic. La présence d'une masse tissulaire chez un patient porteur d'une PCC doit faire évoquer le diagnostic de cancer en première intention ce d'autant qu'il existe une dilatation de la voie biliaire principale et des calcifications pancréatiques peu nombreuses.…”

Section: Discussionunclassified

Pancreatic cancer in patients with chronic calcifying pancreatitis: Computed tomography findings – a retrospective analysis of 48 patients

Mohamed

Ayav

Belle

et al. 2017

European Journal of Radiology

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“…A study from 1999 11 showed that the sensitivity of EUS-FNA for small lesions was modest while another study showed that diagnostic accuracy rises as the size of the mass increases with a reduction in accuracy for lesions more than 40 mm 12 . While additional endoscopic ultrasound imaging features may aid in the differentiation between solid pancreatic mass lesions 13 and are helpful for predicting the possibility of adenocarcinoma 14 , tissue diagnosis is essential for further clinical management.…”

Section: Introductionmentioning

confidence: 99%

Performance characteristic of endoscopic ultrasound-guided fine needle aspiration is unaffected by pancreatic mass size

et al. 2016

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Background and study aims: Despite a well-established tool for diagnosis of pancreatic masses, endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) studies have shown suboptimal diagnostic performance at divergent mass sizes. Since the impact of gold standard follow-up and presence of on-site evaluation on this observation is unknown, we aimed to study the performance characteristics of EUS-FNA under these strict conditions. Patients and methods: EUS-FNA results from pancreatic mass lesions performed between July 2000 and March 2013 were evaluated. All patients with histological follow-up were then stratified into four groups: Group A ( ≤ 10 mm), Group B (11 – 20 mm), Group C (21 – 40 mm), and Group D (> 40 mm). Sensitivity and diagnostic accuracy were calculated for each group and compared. Results: A total of 612 /3832 (16 %) patients with pancreatic masses who underwent EUS-FNA had histology confirmation. Of these, 81 were excluded due to unavailable lesion size, while the rest formed the study cohort. Mean age (SD) was 65.8 years (9.3) with 51.2 % female. The mean number of passes for the entire cohort was 2.9 (SD 1.9; range 1 – 12); patients in group D had a significantly higher number of passes for on-site diagnosis (P = 0.0124). There was no significant difference between the groups for sensitivity (P = 0.1134) or diagnostic accuracy (P = 0.2111). Proportional trend analysis revealed no significant correlation between size and sensitivity (P = 0.6192). The size of lesion measured by EUS was not associated with sensitivity or specificity after adjusting for age, sex, and pancreatic location. Conclusion: In the presence of rapid on-site cytopathology and when final histology is taken as the gold standard, pancreatic mass size does not affect the performance characteristics of EUS-FNA.

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Ratio of Pancreatic Duct Caliber to Width of Pancreatic Gland by Endosonography Is Predictive of Pancreatic Cancer

Abstract: A PDG ratio is a good predictor of PC and is better than PD dilation. This sign should be routinely used by endosonographers to improve EUS diagnostic capability of PC.

Cited by 23 publications

References 22 publications

Radiological Evaluation of Focal Pancreatic Lesions

Radiological Evaluation of Focal Pancreatic Lesions

Pancreatic cancer in patients with chronic calcifying pancreatitis: Computed tomography findings – a retrospective analysis of 48 patients

Performance characteristic of endoscopic ultrasound-guided fine needle aspiration is unaffected by pancreatic mass size

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