Rational approach to long-term use of H2-antagonists

Prevention of Gastric Ulcer Relapse Induced by Indomethacin in Rats by a Mutein of Basic Fibroblast Growth Factor

“…These facts and the results in the present study suggest that not only neu trophils but also eosinophils play an important role in ulcer relapse as well as ulcer formation and the delay in ulcer healing induced by indomethacin. It has been reported that the gastric and duodenal ul cers healed by treatment with H2-RAs often relapse after treatment is stopped and that continuous treatment with H2-RAs after ulcer healing can effectively prevent ulcer relapse (32,33). In the present study, H2-RAs, especially ranitidine, accelerated ulcer healing but could not prevent the ulcer relapse induced by indomethacin after the treat ment was stopped.…”

Medical Therapy of Ménétrier’s Disease with Omeprazole

“…Partial gas trectomy may relieve symptoms, but has an unacceptably high incidence of anastomotic leakage [8], Medical therapy, initially with anticholinergic drugs, showed promise [3], but H2 blockade is now the mainstay of [6], Weight gain, normalisa tion of serum albumin and an improvement in mucosal protein loss have been demon strated with both cimetidine [4] and ranitid ine [9], and Menetrier's disease has been cited as an indication for maintenance H? antago nists [10].…”

Successful Symptomatic Management of a Patient with Ménétrier’s Disease with Long-Term Antibiotic Treatment

“…Despite scattered evidence in the literature, reports of successful conservative management remain anecdotal and mostly involve the application of H 2 blockers or proton-pump inhibitors [7, 8]. In contrast to these conservative measures, some papers are strongly in favor of surgical management, i.e.…”

“…In spite of various attempts to treat patients suffering from MD, there is no consensus about the optimal form of therapy. Symptomatic management as well as long-term administration of H 2 blockers or mucosa protectives have been advocated [3, 7, 8], while other authors have made the case for gastrectomy [9]. …”