Rational construction of a triphenylphosphine-modified tetra-nuclear Cu(<scp>i</scp>) coordinated cluster for enhanced chemodynamic therapy

You, Xin; Hong, Zhao-Guo; Shi, Sheng-Mei; Bian, He‐Dong; Zhang, Yunliang; Zhang, Liangliang; Huang, Fu‐Ping; Zhao, Shulin; Liang, Hong

doi:10.1039/d2dt00063f

Cited by 7 publications

(2 citation statements)

References 26 publications

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“…Furthermore, other copper complexes, such as Cin-ODÀ Cu, a novel copper coordination compound designed by Zhaoguo Hong et al, demonstrated the ability to inhibit tumor growth in both in vitro and in vivo studies. [179] To intensify ROS production in CDT, they synthesized a tetra-nuclear Cu(I) coordinated cluster, [183] which exhibited enhanced anti-tumor abilities through CDT owing to its higher copper content. This promising result opens up possibilities to improve the curative effects of CDT.…”

Section: Copper Complexes In Chemodynamic Therapymentioning

confidence: 99%

Copper and Copper Complexes in Tumor Therapy

Wang,

Tang,

Yuan

et al. 2024

ChemMedChem

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Copper (Cu), a crucial trace element in physiological processes, has garnered significant interest for its involvement in cancer progression and potential therapeutic applications. The regulation of cellular copper levels is essential for maintaining copper homeostasis, as imbalances can lead to toxicity and cell death. The development of drugs that target copper homeostasis has emerged as a promising strategy for anticancer treatment, with a particular focus on copper chelators, copper ionophores, and novel copper complexes. Recent research has also investigated the potential of copper complexes in cancer therapy.

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Section: Copper Complexes In Chemodynamic Therapymentioning

confidence: 99%

Copper and Copper Complexes in Tumor Therapy

Wang,

Tang,

Yuan

et al. 2024

ChemMedChem

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show abstract

“…9,10 Compared with the traditional homo-metallic CDT agents, hetero-metallic Fenton-like centers have attracted increasing attention due to their excellent conversion efficiency for hydrogen peroxide. [11][12][13][14][15][16][17][18] Recently, ferrocene moieties with excellent redox properties have proved to be suitable for the CDT treatment strategy. [19][20][21][22][23] For example, Dong et al prepared a covalent organic framework (COF)-based ferrocene (Fc) and glutathione peroxidase 4 (GP × 4) inhibitor loaded nano drug RSL3@COF-Fc to enhance • OH-induced cellular damage by CDT.…”

Section: Introductionmentioning

confidence: 99%