“…In addition to the identification of inhibitors from drugs, DDAM was applied to the discovery the effective constitutes from herbal medicines using chromatographic-activity analysis. As shown in In addition, parts of the molecules are metabolized by human CYPs to generate chemically reactive intermediate(s) that may bind to a range of biological macromolecules covalently, resulting in protein dysfunction and/or other unexpected effects, such as idiosyncratic toxicity (Hollenberg et al, 2008;He and Feng, 2015;Gu et al, 2022) from clinical drugs and herbal medicines (Ning et al, 2022).…”