2018
DOI: 10.1016/j.msec.2017.12.007
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Rational design of curcumin loaded multifunctional mesoporous silica nanoparticles to enhance the cytotoxicity for targeted and controlled drug release

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Cited by 59 publications
(30 citation statements)
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“…47 Silica NPs were chosen as a nanoplatform given their low toxicity to both prokaryotes 48 and eukaryotes 49 and low environmental impact. 50 Despite the fact that, for silica NPs, curcumin is oen delivered in mesoporous silica [51][52][53] or added to the silica matrix itself, 54 here the compound is functionalised covalently only at the surface of the NPs. The NPs produced are shown to have little antibacterial effect, however a noticeable antibiolm activity.…”
Section: Introductionmentioning
confidence: 99%
“…47 Silica NPs were chosen as a nanoplatform given their low toxicity to both prokaryotes 48 and eukaryotes 49 and low environmental impact. 50 Despite the fact that, for silica NPs, curcumin is oen delivered in mesoporous silica [51][52][53] or added to the silica matrix itself, 54 here the compound is functionalised covalently only at the surface of the NPs. The NPs produced are shown to have little antibacterial effect, however a noticeable antibiolm activity.…”
Section: Introductionmentioning
confidence: 99%
“…They did not show remarkable toxicity even while the incubated concentration increased to 640 mg mL À1 . 49 The synthetic methodology, curcumin loading (wt%), and distinct biological activity of 24 and 25 are summarized in Table 5.…”
Section: Schiff Base Macro-structures For Release Of Curcuminmentioning
confidence: 99%
“…Their high stability, chemical versatility, biocompatibility and low degradability make them ideal carriers for many chemicals (Sun et al 2014). The loading capacity and release efficiency of silica NPs for curcumin were studied by Chen et al (2018a) for targeted and controlled drug release application. The results showed that silica NPs had a high loading capacity (49.6 %) for curcumin and its release efficiency decreased with an increase in pH (10-60 %) in 25 h. Cao et al (2016; evaluated the release efficiency of silica NPs for pesticide and fungicide and observed an initial burst and subsequent sustained release behaviour, which demonstrates the great potential of silica NPs in controlled release systems.…”
Section: Silica Npsmentioning
confidence: 99%